Magnesium chelating 2-hydroxyisoquinoline-1,3(2H, 4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: Discovery of a novel selective inhibitor of the ribonuclease H function

Journal of Medicinal Chemistry

Volumn 54, Issue 6, 2011, Pages 1812-1824

  Billamboz, Muriel ^a   Bailly, Fabrice ^a   Lion, Cédric ^a   Touati, Nadia ^a,b   Vezin, Hervé ^a,b   Calmels, Christina ^c   Andréola, Marie Line ^c   Christ, Frauke ^d   Debyser, Zeger ^d   Cotelle, Philippe ^a  

^a UNIV LILLE   (France)

^b UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE   (France)

^c University Victor Segalen   (France)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXY 1,8 NAPHTHYRIDIN 2 (1H) ONE DERIVATIVE; 2 HYDROXY 4 METHOXYCARBONYLISOQUINOLINE 1,3 (2H,4H)DIONE; 2 HYDROXY 4 METHYLISOQUINOLINE 1,3 (2H,4H)DIONE; 2 HYDROXYISOQUINOLINE 1,3 (2H,4H)DIONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DNA POLYMERASE; EFAVIRENZ; INTEGRASE; ISOQUINOLINE DERIVATIVE; MAGNESIUM DERIVATIVE; MANGANESE; METHYL 2 HYDROXY 1,3 DIOXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLATE; RALTEGRAVIR; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ANTIVIRAL SUSCEPTIBILITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CROSS RESISTANCE; DRUG CYTOTOXICITY; ELECTRON SPIN RESONANCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; NONHUMAN; OXIDATION REDUCTION REACTION; STOICHIOMETRY; VIRUS INHIBITION; VIRUS STRAIN;

EID: 79952789620     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1014692     Document Type: Article

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