Down-regulation of HSP70 sensitizes gastric epithelial cells to apoptosis and growth retardation triggered by H. pylori

BMC Gastroenterology

Volumn 11, Issue , 2011, Pages

  Liu, Weili ^a   Chen, Yan ^b   Lu, Gaofeng ^c   Sun, Leimin ^a   Si, Jianmin ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c ZHEJIANG HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 6; CASPASE 7; CYCLINE; CYTOCHROME C; HEAT SHOCK PROTEIN 70; PROTEIN P21; SMALL INTERFERING RNA; PRIMER DNA;

APOPTOSIS; APOPTOSIS INDUCING FACTOR GENE; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOCHROME C GENE; CYTOSOL; DOWN REGULATION; ENZYME RELEASE; EPITHELIUM CELL; GENE; GROWTH RATE; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; MITOCHONDRION; NICK END LABELING; NUCLEOTIDE SEQUENCE; P21 GENE; PCNA GENE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; STABLE TRANSFECTION; STOMACH EPITHELIUM; UPREGULATION; WESTERN BLOTTING; CELL CYCLE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HELICOBACTER INFECTION; METABOLISM; PATHOGENICITY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; STOMACH MUCOSA;

APOPTOSIS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DNA PRIMERS; DOWN-REGULATION; EPITHELIAL CELLS; GASTRIC MUCOSA; GENE EXPRESSION REGULATION; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HSP70 HEAT-SHOCK PROTEINS; HUMANS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84855166663     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-11-146     Document Type: Article

References (33)

1. Choi SR, Lee SA, Kim YJ, Ok CY, Lee HJ, Hahm KB. Role of heat shock proteins in gastric inflammation and ulcer healing. J Physiol Pharmacol 2009, 60(Suppl 7):5-17.
2. Basu S, Srivastava PK. Heat shock proteins: the fountainhead of innate and adaptive immune responses. Cell Stress Chaperones 2000, 5:443-51.
3. Ishihara T, Suemasu S, Asano T, Tanaka KI, Mizushima T. Stimulation of gastric ulcer healing by heat shock protein 70. Biochem Pharmacol 2011,
4. Asai M, Kawashima D, Katagiri K, Takeuchi R, Tohnai G, Ohtsuka K. Protective effect of a molecular chaperone inducer, paeoniflorin, on the HCl- and ethanol-triggered gastric mucosal injury. Life Sci 2011, 88:350-7.
5. Nardone G, Staibano S, Rocco A, Mezza E, D'armiento FP, Insabato L, et al. Effect of helicobacter pylori infection and its eradication on cell proliferation, DNA status, and oncogene expression in patients with chronic gastritis. Gut 1999, 44:789-99.
6. Fan XG, Kelleher D, Fan XJ, et al. Helicobacter pylori increases proliferation of gastric epithelial cells. Gut 1996, 38:19-22.
7. Klaamas K, Kurtenkov O, von Mensdorff-Pouilly S, Shjapnikova L, Miljukhina L, Brjalin V, et al. Impact of Helicobacter pylori infection on the humoral immune response to MUC1 peptide in patients with chronic gastric diseases and gastric cancer. Immunol Invest 2007, 36(4):371-86.
8. Konturek JW, Fischer H, Konturek PC, Huber V, Boknik P, Luess H, et al. Heat shock protein 70 (hsp70) in gastric adaptation to aspirin in Helicobacter pylori infection. J Physiol Pharmacol 2001, 52:153-64.
9. Pierzchalski P, Krawiec A, Ptak-Belowska A, Baranska A, Konturek SJ, Pawlik WW. The mechanism of heat-shock protein 70 gene expression abolition in gastric epithelium caused by Helicobacter pylori infection. Helicobacter 2006, 11(2):96-104.
10. Huff JL Hansen LM, Solnick JV. Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque. Infect Immun 2004, 72:5216-26.
11. Axsen WS, Styer CM, Solnick JV. Inhibition of heat shock protein expression by helicobacter pylori. Microb Pathog 2009, 47:231-6.
12. Liu WL, Chen SJ, Chen Y, Sun LM, Zhang W, Zeng YM, et al. Protective effects of heat shock protein70 induced by geranyl-geranylacetone in atrophic gastritis in rats. Acta Pharmacologica Sinica 2007, 28:1001-6.
13. Gabai VL, Budagova KR, Sherman MY. Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents. Oncogene 2005, 24:3328-38.
14. Suemasu S, Tanaka K, Namba T, Ishihara T, Katsu T, Fujimoto M, et al. A role for HSP70 in protecting against indomethacin-induced gastric lesions. J Biol Chem 2009, (284):19705-15.
15. Rokutan K. Role of heat shock proteins in gastric mucosal protection. J Gastroenterol Hepatol 2000, 15(Suppl):12-9.
16. Tsukimi Y, Nakai H, Itoh S, Amagase K, Okabe S. Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats. J Physiol Pharmacol 2001, 52:391-406.
17. Tomomitsu T, Tomoyuki S, Tomiyasu A, Masakatsu N, Daisuke Y, Masaaki O, et al. The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. Anticancer Research 2009, 29:3453-58. 16-20.
18. Rohde M, Daugaard M, Jensen MH, et al. Members of the heat -shock protein 70 family promote cancer cell growth by distinct mechanism. Genes & Development 2005, 19:570-82.
19. Ogryzko VV, Wong P, Howard BH. WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases. Mol Cell Biol 1997, 17:4877-4882.
20. Zhu H, Zhang L, Wu S, Teraishi F, Davis JJ, Jacob D, et al. Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino] ethanol in correlation with activation of ERK. Oncogene 2004, 23:4984-92.
21. Chen J, Jackson PK, Kirschner MW, Dutta A. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 1995, 374:386-388.
22. Gartel AL, Radhakrishnan SK, . Lost in transcription p21 repression, mechanisms, and consequences. Cancer Res 2005, 65(10):3980-5. Lost in transcription.
23. Abbas T, Dutta A. P21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 2009, 9(6):400-14.
24. Zhang H, Fang DC, Lan CH, Luo YH. Helicobacter pylori infection induces apoptosis in gastric cancer cells through the mitochondrial pathway. J Gastroenterol Hepatol 2007, 22:1051-6.
25. Chiozzi V, Mazzini G, Oldani A, Sciullo A, Ventura U, Romano M, et al. Relationship between Vac A toxin and ammonia in Helicobacter pylori-induced apoptosis in human gastric epithelial cells. J Physiol Pharmacol 2009, 60:23-30.
26. Yang J, Liu XS, Bhalla K, Kim CN, Ibrada AM, Cai JY, et al. Prevention of apoptosis by Bcl-2:release of cytochrome c from mitochondria blocked. Science 1997, 275:1129-32.
27. Garland JM, Rudin C. Cytochrome c Induces Caspase-Dependent Apoptosis in Intact Hematopoietic cells and overrides apoptosis suppression mediated by bcl-2, growth factor signaling, MAP-Kinase-Kinase, and malignant change. Blood 1998, 92:1235-46.
28. Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 2001, 410:549-54.
29. Susjin SA, Daugas E, Ravagnan L, Samejima K, Zamzami N, Loeffler M, et al. Two distinct pathways leading to nuclear apoptosis. J Exp Med 2000, 192:571-80.
30. Cregan SP, Dawson VL, Slack RS. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene 2004, 23:2785-96.
31. Ashkorab H, Dashwood RH, Dashwood MM, Zaidi SI, Hewitt SM, Green WR, et al. H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria. Helicobacter 2008, 13:506-17.
32. Novoselova TV, Margulis BA, Novoselov SS, et al. Treatment with extracellular HSP70/HSC70 protein polyglutamine toxicity and aggregation. J Neurochem 2005, 94:597-606.
33. Robinson MB, Tidwell JL, Gould T, et al. Extracellular heat shock protein 70: a critical component for motoneuron survival. J Neurosci 2005, 25:9735-45.