Helicobacter pylori infection induces apoptosis in gastric cancer cells through the mitochondrial pathway

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue 7, 2007, Pages 1051-1056

  Zhang, Hao ^a   Fang, Dian Chun ^a   Lan, Chun Hui ^a   Luo, Yuan Hui ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Caspases; Gastric cancer cells; Helicobacter pylori; Mitochondrial pathway

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID;

APOPTOSIS; ARTICLE; BACTERIAL STRAIN; CANCER CELL CULTURE; COCULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA; UPREGULATION; WESTERN BLOTTING;

EID: 34347370537     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2007.04959.x     Document Type: Article

References (35)

1. Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol. Rev. 2000 22 : 283 97.
2. Miwa H, Go MF, Sato NH. pylori and gastric cancer: the Asian enigma. Am. J. Gastroenterol. 2002 97 : 1106 12.
3. Huang JQ, Sridhar S, Chen Y, Hunt RH. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology 1998 114 : 1169 79.
4. Jones RG, Trowbridge DB, Go MF. Helicobacter pylori infection in peptic ulcer disease and gastric malignancy. Front Biosci. 2001 6 : E213 26.
5. Moss SF, Sordillo EM, Abdalla AM et al. Increased gastric epithelial cell apoptosis associated with colonization with cagA+ Helicobacter pylori strains. Cancer Res. 2001 61 : 1406 11.
6. Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998 281 : 1305 8.
7. Wallach D, Boldin M, Varfolomeev E, Beyaert R, Vandenabeele P, Fiers W. Cell death induction by receptors of the TNF family: towards a molecular understanding. FEBS Lett. 1997 410 : 96 106.
8. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998 281 : 1309 12.
9. Rudi J, Kuck D, Strand S et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J. Clin. Invest. 1998 102 : 1506 14.
10. Houghton J, Korah RM, Condon MR, Kim KH. Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway. Dig. Dis. Sci. 1999 44 : 465 78.
11. Houghton J, Macera-Bloch LS, Harrison L, Kim KH, Korah RM. Tumor necrosis factor alpha and interleukin 1beta up-regulate gastric mucosal Fas antigen expression in Helicobacter pylori infection. Infect. Immun. 2000 68 : 1189 95.
12. Liu HF, Liu WW, Fang DC, Wang ZH, Liang HJ, Men RF. Effect of Helicobacter pylori on gastric epithelial cell proliferation and apoptosis. Chin. J. Dig. Endosc. 1998 15 : 91 3.
13. Liu HF, Liu WW, Fang DC, Wang GA, Teng XC. Effect of Helicobacter pylori infection on bax protein expression in patients with gastric precancerous lesions. World Chin. J. Digestol. 2003 11 : 22 4.
14. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 1999 13 : 1899 911.
15. Lee EH, Wan XH, Song J et al. Lens epithelial cell death and reduction of anti-apoptotic protein Bcl-2 in human anterior polar cataracts. Mol. Vis. 2002 8 : 235 40.
16. Tafani M, Karpinich NO, Hurster KA et al. Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition. J. Biol. Chem. 2002 277 : 10073 82.
17. Shen XZ. Protection of HemeOxygenase-1 on acetic acid induced gastric ulcer in rats. World Chin. J. Digestol. 2000 8 : 979 82.
18. Varfolomeev EE, Schuchmann M, Luria V et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 1998 9 : 267 76.
19. Strasser A, Harris AW, Huang DC, Krammer PH, Cory S. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 1995 14 : 6136 47.
20. Newton K, Harris AW, Bath ML, Smith KG, Strasser A. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J 1998 17 : 706 18.
21. Allen RT, Cluck MW, Agrawal DK. Mechanisms controlling cellular suicide. Role of Bcl-2 and caspases. Cell Mol. Life Sci. 1998 54 : 427 45.
22. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998 281 : 1322 6.
23. Huang DC, Strasser A. BH3-Only proteins-essential initiators of apoptotic cell death. Cell 2000 103 : 839 42.
24. Bouillet P, Strasser A. BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J. Cell Sci. 2002 115 : 1567 74.
25. Suzuki M, Youle RJ, Tjandra N. Structure of Bax: coregulation of dimer formation and intracellular localization. Cell 2000 103 : 645 54.
26. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998 94 : 481 90.
27. Konturek PC, Pierzchalski P, Konturek SJ et al. Helicobacter pylori induces apoptosis in gastric mucosa through an upregulation of Bax expression in humans. Scand. J. Gastroenterol. 1999 34 : 375 83.
28. Zhang H, Fang DC, Wang RQ, Yang SM, Liu HF, Luo YH. Effect of Helicobacter pylori infection on expression of Bcl-2 family members in gastric adenocarcinoma. World J. Gastroenterol. 2004 10 : 227 30.
29. Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998 94 : 491 501.
30. Shibayama K, Doi Y, Shibata N et al. Apoptotic signaling pathway activated by Helicobacter pylori infection and increase of apoptosis-inducing activity under serum-starved conditions. Infect. Immun. 2001 69 : 3181 9.
31. Yang Y, Deng CS, Peng JZ, Wong BC, Lam SK, Xia HH. Effect of Helicobacter pylori on apoptosis and apoptosis related genes in gastric cancer cells. Mol. Pathol. 2003 56 : 19 24.
32. Kurosawa A, Miwa H, Hirose M, Tsune I, Nagahara A, Sato N. Inhibition of cell proliferation and induction of apoptosis by Helicobacter pylori through increased phosphorylated p53, p21 and Bax expression in endothelial cells. J. Med. Microbiol 2002 51 : 385 91.
33. Choi IJ, Kim JS, Kim JM, Jung HC, Song IS. Effect of inhibition of extracellular signal-regulated kinase 1 and 2 pathway on apoptosis and bcl-2 expression in Helicobacter pylori-infected AGS cells. Infect. Immun. 2003 71 : 830 7.
34. Potthoff A, Ledig S, Martin J et al. Significance of the caspase family in Helicobacter pylori induced gastric epithelial apoptosis. Helicobacter 2002 7 : 367 77.
35. Lan CH, Fang DC, Fan LL et al. The role of mitochondrial damages in Helicobacter pylori-induced apoptosis of gastric cancer cells. Zhonghua Nei Ke Za Zhi 2005 44 : 748 50.