Applications of the phytomedicine Echinacea purpurea (purple coneflower) in infectious diseases

Journal of Biomedicine and Biotechnology

Volumn 2012, Issue , 2012, Pages

  Hudson, James B ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; ECHINACEA PURPUREA EXTRACT; MUCIN; ANTIINFECTIVE AGENT; ANTIOXIDANT; ANTIVIRUS AGENT; PLANT EXTRACT;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; BACTERIAL INFECTION; CALICIVIRUS; CLOSTRIDIUM DIFFICILE; CORONAVIRUS; CYTOKINE RELEASE; DRUG POTENCY; ECHINACEA PURPUREA; EPITHELIUM CELL; FUNGUS; GENE EXPRESSION; HERPES SIMPLEX VIRUS; HERPES VIRUS; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; INFECTION; INFLUENZA A; INFLUENZA VIRUS; MACROPHAGE; MEDICINE; MIXED INFECTION; NONHUMAN; PARASITE; PHAGOCYTOSIS; PHYTOMEDICINE; POLIOMYELITIS VIRUS; RESPIRATORY EPITHELIUM; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT INFECTION; REVIEW; RHINOVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SKIN INFECTION; UPREGULATION; VIRAL RESPIRATORY TRACT INFECTION; VIRION; ANIMAL; CHEMISTRY; ECHINACEA; METHODOLOGY; PHYTOTHERAPY;

ECHINACEA (ASTERACEAE); ECHINACEA PURPUREA;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIOXIDANTS; ANTIVIRAL AGENTS; ECHINACEA; HUMANS; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 84855165264     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2012/769896     Document Type: Review

References (130)

1. Hobbs C., Echinacea: The Immune Herb 1990 Santa Cruz, Calif, USA American Botanical Council, Botanica Press
2. Foster S., Echinacea, Natures Immune Enhancer 1991 Rochester, Vt, USA Healing Arts Press
3. Barrett B., Medicinal properties of Echinacea: a critical review Phytomedicine 2003 10 1 66 86 (Pubitemid 36262210)
4. Binns S. E., Baum B. R., Arnason J. T., A taxonomic revision of Echinacea (Asteraceae: Heliantheae) Systematic Botany 2002 27 3 610 632
5. Barnes J., Anderson L. A., Gibbons S., Phillipson J. D., Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties Journal of Pharmacy and Pharmacology 2005 57 8 929 954 (Pubitemid 41039828)
6. Bauer R., Lawson L. D., Bauer R., Echinacea: biological effects and active principals Phytomedicines of Europe: Chemistry and Biological Activity 1998 691 Washington, DC, USA American Chemical Society 140 157 American Chemical Society Symposium series (Pubitemid 128436682)
7. Binns S. E., Livesey J. F., Arnason J. T., Baum B. R., Phytochemical variation in Echinacea from roots and flowerheads of wild and cultivated populations Journal of Agricultural and Food Chemistry 2002 50 13 3673 3687 (Pubitemid 34640689)
8. Gwaltney J. M., Clinical significance and pathogenesis of viral respiratory infections American Journal of Medicine 2002 112 6 13S 18S
9. See H., Wark P., Innate immune response to viral infection of the lungs Paediatric Respiratory Reviews 2008 9 4 243 250
10. Nichols W. G., Peck Campbell A. J., Boeckh M., Respiratory viruses other than influenza virus: impact and therapeutic advances Clinical Microbiology Reviews 2008 21 2 274 290 (Pubitemid 351555508)
11. Hudson J., Vimalanathan S., Kang L., Amiguet V. T., Livesey J., Arnason J. T., Characterization of antiviral activities in Echinacea root preparations Pharmaceutical Biology 2005 43 9 790 796 (Pubitemid 43336370)
12. Vimalanathan S., Kang L., Amiguet V. T., Livesey J., Arnason J. T., Hudson J., Echinacea purpurea aerial parts contain multiple antiviral compounds Pharmaceutical Biology 2005 43 9 740 745 (Pubitemid 43336361)
13. Pleschka S., Stein M., Schoop R., Hudson J. B., Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian Influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV) Virology Journal 2009 6, article no. 197
14. Ludwig S., Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy Journal of Antimicrobial Chemotherapy 2009 64 1 1 4
15. Fedson D. S., Confronting the next influenza pandemic with anti-inflammatory and immunomodulatory agents: why they are needed and how they might work Influenza and other Respiratory Viruses 2009 3 4 129 142
16. Roxas M., Jurenka J., Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations Alternative Medicine Review 2007 12 1 25 48 (Pubitemid 46668726)
17. Hudson J. B., The use of herbal extracts in the control of influenza Journal of Medicinal Plant Research 2009 3 13 1189 1194
18. Johnston S. L., Overview of virus-induced airway disease Proceedings of the American Thoracic Society 2005 2 2 150 156 (Pubitemid 41233383)
19. Eccles R., Understanding the symptoms of the common cold and influenza Lancet Infectious Diseases 2005 5 11 718 725 (Pubitemid 41505360)
20. Ruuskanen O., Lahti E., Jennings L. C., Murdoch D. R., Viral pneumonia The Lancet 2011 377 9773 1264 1275
21. Mosser A. G., Vrtis R., Burchell L., Lee W. M., Dick C. R., Weisshaar E., Bock D., Swenson C. A., Cornwell R. D., Meyer K. C., Jarjour N. N., Busse W. W., Gern J. E., Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues American Journal of Respiratory and Critical Care Medicine 2005 171 6 645 651 (Pubitemid 40365422)
22. Zhang L., Peeples M. E., Boucher R. C., Collins P. L., Pickles R. J., Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology Journal of Virology 2002 76 11 5654 5666 (Pubitemid 34517916)
23. Burns J. J., Zhao L., Taylor E. W., Spelman K., The influence of traditional herbal formulas on cytokine activity Toxicology 2010 278 1 140 159
24. Diamond G., Beckloff N., Ryan L. K., Host defense peptides in the oral cavity and the lung: similarities and differences Journal of Dental Research 2008 87 10 915 927
25. Evans S. E., Xu Y., Tuvim M. J., Dickey B. F., Inducible innate resistance of lung epithelium to infection Annual Review of Physiology 2009 72 413 435
26. Vareille M., Kieninger E., Edwards M. R., Regamey N., The airway epithelium: soldier in the fight against respiratory viruses Clinical Microbiology Reviews 2011 24 1 210 229
27. Bengtson S. H., Eddleston J., Christiansen S. C., Zuraw B. L., Double-stranded RNA increases kinin B1 receptor expression and function in human airway epithelial cells International Immunopharmacology 2007 7 14 1880 1887 (Pubitemid 350138510)
28. Ghezzi P., Role of glutathione in immunity and inflammation in the lung International Journal of General Medicine 2011 4 105 113
29. Calixto J. B., Campos M. M., Otuki M. F., Santos A. R. S., Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules Planta Medica 2004 70 2 93 103 (Pubitemid 38299768)
30. Wang X., Jia W., Zhao A., Wang X., Anti-influenza agents from plants and traditional Chinese medicine Phytotherapy Research 2006 20 5 335 341
31. Cannell J. J., Zasloff M., Garland C. F., Scragg R., Giovannucci E., On the epidemiology of influenza Virology Journal 2008 5, article no. 29
32. Suzuki Y., The highly pathogenic avian influenza H5N1initial molecular signals for the next influenza pandemic Chang Gung Medical Journal 2009 32 3 258 263
33. Michaelis M., Doerr H. W., Cinatl J., Novel swine-origin influenza A virus in humans: another pandemic knocking at the door Medical Microbiology and Immunology 2009 198 3 175 183
34. Neumann G., Noda T., Kawaoka Y., Emergence and pandemic potential of swine-origin H1N1 influenza virus Nature 2009 459 7249 931 939
35. Boyce W. M., Sandrock C., Kreuder-Johnson C., Kelly T., Cardona C., Avian influenza viruses in wild birds: a moving target Comparative Immunology, Microbiology and Infectious Diseases 2009 32 4 275 286
36. Brundage J. F., Shanks G. D., Deaths from bacterial pneumonia during 1918-19 influenza pandemic Emerging Infectious Diseases 2008 14 8 1193 1199
37. Jefferson T., Di Pietrantonj C., Debalini M. G., Rivetti A., Demicheli V., Inactivated influenza vaccines: methods, policies, and politics Journal of Clinical Epidemiology 2009 62 7 677 686
38. Poland G. A., Jacobson R. M., Ovsyannikova I. G., Influenza virus resistance to antiviral agents: a plea for rational use Clinical Infectious Diseases 2009 48 9 1254 1256
39. Uchide N., Ohyama K., Toyoda H., Current and future anti-influenza virus drugs Open Antimicrobial Agents Journal 2010 2 34 48
40. Jefferson T., Demicheli V., Rivetti D., Jones M., Di Pietrantonj C., Rivetti A., Antivirals for influenza in healthy adults: systematic review Lancet 2006 367 9507 303 313 (Pubitemid 43151463)
41. Cheng P. K. C., Leung T. W. C., Ho E. C. M., Leung P. C. K., Ng A. Y. Y., Lai M. Y. Y., Lim W. W. L., Oseltamivir-and amantadine-resistant influenza viruses A (H1N1) Emerging Infectious Diseases 2009 15 6 966 968
42. Binns S. E., Hudson J., Merali S., Arnason J. T., Antiviral activity of characterized extracts from Echinacea spp. (Heliantheae: Asteraceae) against Herpes simplex virus (HSV-I) Planta Medica 2002 68 9 780 783 (Pubitemid 35177620)
43. Hudson J. B., Plant photosensitizers with antiviral properties Antiviral Research 1989 12 2 55 74 (Pubitemid 19236887)
44. Sharma M., Anderson S. A., Schoop R., Hudson J. B., Induction of multiple pro-inflammatory cytokines by respiratory viruses and reversal by standardized Echinacea, a potent antiviral herbal extract Antiviral Research 2009 83 2 165 170
45. Vohra S., Adams D., Hudson J. B., Moore J. A., Vimalanathan S., Sharma M., Burt A. J., Lamont E., Lacaze N., Arnason J. T., Lee T. D. G., Selection of natural health products for clinical trials: a preclinical template Canadian Journal of Physiology and Pharmacology 2009 87 5 371 378
46. Sharma M., Arnason J. T., Burt A., Hudson J. B., Echinacea extracts modulate the pattern of chemokine and cytokine secretion in rhinovirus-infected and uninfected epithelial cells Phytotherapy Research 2006 20 2 147 152 (Pubitemid 43266841)
47. Altamirano-Dimas M., Sharma M., Hudson J. B., Echinacea and anti-inflammatory cytokine responses: results of a gene and protein array analysis Pharmaceutical Biology 2009 47 6 500 508
48. Sharma M., Schoop R., Hudson J. B., Echinacea as an antiinflammatory agent: the influence of physiologically relevant parameters Phytotherapy Research 2009 23 6 863 867
49. Hudson J. B., The multiple actions of the phytomedicine Echinacea in the treatment of colds and flu Journal of Medicinal Plant Research 2010 4 25 2746 2752
50. Sharma M., Arnason J. T., Hudson J. B., Echinacea extracts modulate the production of multiple transcription factors in uninfected cells and rhinovirus-infected cells Phytotherapy Research 2006 20 12 1074 1079 (Pubitemid 44951712)
51. Fuchs R., Blaas D., Uncoating of human rhinoviruses Reviews in Medical Virology 2010 20 5 281 297
52. Vimalanathan S., Arnason J. T., Hudson J. B., Anti-inflammatory activities of Echinacea extracts do not correlate with traditional marker components Pharmaceutical Biology 2009 47 5 430 435
53. Rose M. C., Voynow J. A., Respiratory tract mucin genes and mucin glycoproteins in health and disease Physiological Reviews 2006 86 1 245 278
54. Zhu L., Lee P. K., Lee W. M., Zhao Y., Yu D., Chen Y., Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway American Journal of Respiratory Cell and Molecular Biology 2009 40 5 610 619
55. Sharma M., Schoop R., Hudson J. B., The efficacy of Echinacea in a 3-D tissue model of human airway epithelium Phytotherapy Research 2010 24 6 900 904
56. Nickerson C. A., Richter E. G., Ott C. M., Studying host-pathogen interactions in 3-D: organotypic models for infectious disease and drug development Journal of Neuroimmune Pharmacology 2007 2 1 26 31
57. Klausner M., Ayehunie S., Breyfogle B. A., Wertz P. W., Bacca L., Kubilus J., Organotypic human oral tissue models for toxicological studies Toxicology in Vitro 2007 21 5 938 949 (Pubitemid 46603236)
58. Hudson J., Altamirano M., The application of DNA micro-arrays (gene arrays) to the study of herbal medicines Journal of Ethnopharmacology 2006 108 1 2 15 (Pubitemid 44498998)
59. Altamirano-Dimas M., Hudson J. B., Cochrane D., Nelson C., Arnason J. T., Modulation of immune response gene expression by Echinacea extracts: results of a gene array analysis Canadian Journal of Physiology and Pharmacology 2007 85 11 1091 1098 (Pubitemid 351196408)
60. Senchina D. S., Martin A. E., Buss J. E., Kohut M. L., Effects of Echinacea extracts on macrophage antiviral activities Phytotherapy Research 2010 24 6 810 816
61. Sharma M., Vohra S., Arnason J. T., Hudson J. B., Echinacea extracts contain significant and selective activities against human pathogenic bacteria Pharmaceutical Biology 2008 46 1-2 111 116 (Pubitemid 351196232)
62. Sharma S. M., Anderson M., Schoop S. R., Hudson J. B., Bactericidal and anti-inflammatory properties of a standardized Echinacea extract (Echinaforce ): dual actions against respiratory bacteria Phytomedicine 2010 17 8-9 563 568
63. Tsai P. J., Chen Y. H., Hsueh C. H., Hsieh H. C., Liu Y. H., Wu J. J., Tsou C. C., Streptococcus pyogenes induces epithelial inflammatory responses through NF- B/MAPK signaling pathways Microbes and Infection 2006 8 6 1440 1449
64. Tart A. H., Walker M. J., Musser J. M., New understanding of the group A Streptococcus pathogenesis cycle Trends in Microbiology 2007 15 7 318 325 (Pubitemid 47017709)
65. Wang S. M., Lu I. H., Lin Y. L., Lin Y. S., Wu J. J., Chuang W. J., Lin M. T., Liu C. C., The severity of Streptococcus pyogenes infections in children is significantly associated with plasma levels of inflammatory cytokines Diagnostic Microbiology and Infectious Disease 2008 61 2 165 169 (Pubitemid 351680367)
66. Beisswenger C., Lysenko E. S., Weiser J. N., Early bacterial colonization induces toll-like receptor-dependent transforming growth factor signaling in the epithelium Infection and Immunity 2009 77 5 2212 2220
67. Erwin A. L., Smith A. L., Nontypeable Haemophilus influenzae: understanding virulence and commensal behavior Trends in Microbiology 2007 15 8 355 362 (Pubitemid 47126851)
68. Diederen B. M. W., Legionella spp. and Legionnaires' disease Journal of Infection 2008 56 1 1 12 (Pubitemid 350253650)
69. Isberg R. R., O'Connor T. J., Heidtman M., The Legionella pneumophila replication vacuole: making a cosy niche inside host cells Nature Reviews Microbiology 2009 7 1 13 24
70. Diep B. A., Otto M., The role of virulence determinants in community-associated MRSA pathogenesis Trends in Microbiology 2008 16 8 361 369
71. Rubinstein E., Kollef M. H., Nathwani D., Pneumonia caused by methicillin-resistant Staphylococcus aureus Clinical Infectious Diseases 2008 46 5 S378 S385
72. Sajjan U., Wang Q., Zhao Y., Gruenert D. C., Hershenson M. B., Rhinovirus disrupts the barrier function of polarized airway epithelial cells American Journal of Respiratory and Critical Care Medicine 2008 178 12 1271 1281
73. Ishizuka S., Yamaya M., Suzuki T., Takahashi H., Ida S., Sasaki T., Inoue D., Sekizawa K., Nishimura H., Sasaki H., Effects of rhinovirus infection on the adherence of Steptococcuspneumoniae to cultured human airway epithelial cells Journal of Infectious Diseases 2003 188 12 1928 1939 (Pubitemid 38064880)
74. Avadhanula V., Rodriguez C. A., De Vincenzo J. P., Wang Y., Webby R. J., Ulett G. C., Adderson E. E., Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner Journal of Virology 2006 80 4 1629 1636 (Pubitemid 43228704)
75. Peltola V. T., Murti K. G., McCullers J. A., Influenza virus neuraminidase contributes to secondary bacterial pneumonia Journal of Infectious Diseases 2005 192 2 249 257 (Pubitemid 40993394)
76. Sajjan U. S., Jia Y., Newcomb D. C., Bentley J. K., Lukacs N. W., LiPuma J. J., Hershenson M. B., H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression FASEB Journal 2006 20 12 E1419 E1429
77. Hudson J., Towers G. H. N., Phytomedicines as antivirals Drugs of the Future 1999 24 3 295 320 (Pubitemid 29214210)
78. Khan M. T. H., Ather A., Thompson K. D., Gambari R., Extracts and molecules from medicinal plants against herpes simplex viruses Antiviral Research 2005 67 2 107 119 (Pubitemid 41112627)
79. Kurokawa I., Danby F. W., Ju Q., Wang X., Xiang L. F., Xia L., Chen W., Nagy I., Picardo M., Suh D. H., Ganceviciene R., Schagen S., Tsatsou F., Zouboulis C. C., New developments in our understanding of acne pathogenesis and treatment Experimental Dermatology 2009 18 10 821 832
80. Docherty J. J., McEwen H. A., Sweet T. J., Bailey E., Booth T. D., Resveratrol inhibition of Propionibacterium acnes Journal of Antimicrobial Chemotherapy 2007 59 6 1182 1184 (Pubitemid 47078720)
81. Kim S. S., Kim J. Y., Lee N. H., Hyun C. G., Antibacterial and anti-inflammatory effects of Jeju medicinal plants against acne-inducing bacteria Journal of General and Applied Microbiology 2008 54 2 101 106 (Pubitemid 351850737)
82. Sharma M., Schoop R., Suter A., Hudson J. B., The potential use of Echinacea in acne: control of Propionibacterium acnes growth and inflammation Phytotherapy Research 2011 25 4 517 521
83. Binns S. E., Purgina B., Bergeron C., Smith M. L., Ball L., Baum B. R., Arnason J. T., Light-mediated antifungal activity of Echinacea extracts Planta Medica 2000 66 3 241 244 (Pubitemid 30235585)
84. Merali S., Binns S., Paulin-Levasseur M., Ficker C., Smith M., Baum B., Brovelli E., Arnason J. T., Antifungal and anti-inflammatory activity of the genus Echinacea Pharmaceutical Biology 2003 41 6 412 420 (Pubitemid 37468119)
85. Bartlett J. G., The new epidemic of Clostridium difficileassociated enteric disease Annals of Internal Medicine 2006 145 10 758 764 (Pubitemid 351650356)
86. Cloud J., Kelly C. P., Update on Clostridium difficile associated disease Current Opinion in Gastroenterology 2007 23 1 4 9 (Pubitemid 44875902)
87. Hill L. L., Foote J. C., Erickson B. D., Cerniglia C. E., Denny G. S., Echinacea purpurea supplementation stimulates select groups of human gastrointestinal tract microbiota Journal of Clinical Pharmacy and Therapeutics 2006 31 6 599 604 (Pubitemid 44813772)
88. WHO Expert Committee on the Control of Leishmaniases,. WHO technical report series, no. 949, Geneva, Switzerland, March 2010
89. Hay A. E., Merza J., Landreau A., Litaudon M., Pagniez F., Pape P. L., Richomme P., Antileishmanial polyphenols from Garcinia vieillardii Fitoterapia 2008 79 1 42 46 (Pubitemid 350225634)
90. Canlas J., Hudson J. B., Sharma M., Nandan D., Echinacea and trypanasomatid parasite interactions: growth-inhibitory and anti-inflammatory effects of Echinacea Pharmaceutical Biology 2010 48 9 1047 1052
91. Calixto J. B., Otuki M. F., Santos A. R. S., Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor B (NF- B) Planta Medica 2003 69 11 973 983 (Pubitemid 38064684)
92. Chen X. M., Hu C., Raghubeer E., Kitts D. D., Effect of high pressure pasteurization on bacterial load and bioactivity of Echinacea purpurea Journal of Food Science 2010 75 7 C613 C618
93. See D. M., Broumand N., Sahl L., Tilles J. G., In vitro effects of Echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients Immunopharmacology 1997 35 3 229 235 (Pubitemid 27063822)
94. Brush J., Mendenhall E., Guggenheim A., Chan T., Connelly E., Soumyanath A., Buresh R., Barrett R., Zwickey H., The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans Phytotherapy Research 2006 20 8 687 695
95. Randolph R. K., Gellenbeck K., Stonebrook K., Brovelli E., Qian Y., Bankaitis-Davis D., Cheronis J., Regulation of human immune gene expression as influenced by a commercial blended Echinacea product: preliminary studies Experimental Biology and Medicine 2003 228 9 1051 1056 (Pubitemid 37222174)
96. Brovelli E. A., Rua D., Roh-Schmidt H., Chandra A., Lamont E., Noratto G. D., Human gene expression as a tool to determine horticultural maturity in a bioactive plant (Echinacea purpurea L. Moench) Journal of Agricultural and Food Chemistry 2005 53 21 8156 8161 (Pubitemid 41564621)
97. Wang C. Y., Staniforth V., Chiao M. T., Hou C. C., Wu H. M., Yeh K. C., Chen C. H., Hwang P. I., Wen T. N., Shyur L. F., Yang N. S., Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cells BMC Genomics 2008 9, article no. 479
98. Benson J. M., Pokorny A. J., Rhule A., Wenner C. A., Kandhi V., Cech N. B., Shepherd D. M., Echinacea purpurea extracts modulate murine dendritic cell fate and function Food and Chemical Toxicology 2010 48 5 1170 1177
99. Roesler J., Steinmuller C., Kiderlen A., Emmendorffer A., Wagner H., Lohmann-Matthes M. L., Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to mice mediates protection against systemic infections with Listeria monocytogenes and Candida albicans International Journal of Immunopharmacology 1991 13 1 27 37
100. Steinmuller C., Roesler J., Grottrup E., Franke G., Wagner H., Lohmann-Matthes M. L., Polysaccharides isolated from plant cell cultures of Echinacea purpurea enhance the resistance of immunosuppressed mice against systemic infections with Candida albicans and Listeria monocytogenes International Journal of Immunopharmacology 1993 15 5 605 614 (Pubitemid 23216864)
101. Matthias A., Banbury L., Stevenson L. M., Bone K. M., Leach D. N., Lehmann R. P., Alkylamides from Echinacea modulate induced immune responses in macrophages Immunological Investigations 2007 36 2 117 130 (Pubitemid 46385593)
102. Guiotto P., Woelkart K., Grabnar I., Voinovich D., Perissutti B., Invernizzi S., Granzotto M., Bauer R., Pharmacokinetics and immunomodulatory effects of phytotherapeutic lozenges (bonbons) with Echinacea purpurea extract Phytomedicine 2008 15 8 547 554
103. Gertsch J., Schoop R., Kuenzle U., Suter A., Echinacea alkylamides modulate TNF- gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways FEBS Letters 2004 577 3 563 569 (Pubitemid 39535349)
104. Sullivan A. M., Laba J. G., Moore J. A., Lee T. D. G., Echinacea-induced macrophage activation Immunopharmacology and Immunotoxicology 2008 30 3 553 574
105. Cech N. B., Kandhi V., Davis J. M., Hamilton A., Eads D., Laster S. M., Echinacea and its alkylamides: effects on the influenza A-induced secretion of cytokines, chemokines, and PGE2 from RAW 264.7 macrophage-like cells International Immunopharmacology 2010 10 10 1268 1278
106. Rininger J. A., Kickner S., Chigurupati P., McLean A., Franck Z., Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells Journal of Leukocyte Biology 2000 68 4 503 510
107. Goel V., Chang C., Slama J. V., Barton R., Bauer R., Gahler R., Basu T. K., Echinacea stimulates macrophage function in the lung and spleen of normal rats Journal of Nutritional Biochemistry 2002 13 8 487 492 (Pubitemid 34876983)
108. Roesler J., Emmendorffer A., Steinmuller C., Luettig B., Wagner H., Lohmann-Matthes M. L., Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to test subjects mediates activation of the phagocyte system International Journal of Immunopharmacology 1991 13 7 931 941
109. Fusco D., Liu X., Savage C., Taur Y., Xiao W., Kennelly E., Yuan J., Cassileth B., Salvatore M., Papanicolaou G. A., Echinacea purpurea aerial extract alters course of influenza infection in mice Vaccine 2010 28 23 3956 3962
110. Currier N. L., Miller S. C., Natural killer cells from aging mice treated with extracts from Echinacea purpurea are quantitatively and functionally rejuvenated Experimental Gerontology 2000 35 5 627 639
111. Delorme D., Miller S. C., Dietary consumption of Echinacea by mice afflicted with autoimmune (type I) diabetes: effect of consuming the herb on hemopoietic and immune cell dynamics Autoimmunity 2005 38 6 453 461 (Pubitemid 41671556)
112. Brousseau M., Miller S. C., Enhancement of natural killer cells and increased survival of aging mice fed daily Echinacea root extract from youth Biogerontology 2005 6 3 157 163 (Pubitemid 41131165)
113. Lans C., Turner N., Khan T., Brauer G., Boepple W., Ethnoveterinary medicines used for ruminants in British Columbia, Canada Journal of Ethnobiology and Ethnomedicine 2007 3, article no. 11
114. Lans C., Turner N., Khan T., Brauer G., Ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in British Columbia, Canada Veterinary Parasitology 2007 148 3-4 325 340 (Pubitemid 47268651)
115. Allen P. C., Dietary supplementation with Echinacea and development of immunity to challenge infection with coccidia Parasitology Research 2003 91 1 74 78 (Pubitemid 37159585)
116. Hermann J. R., Honeyman M. S., Zimmerman J. J., Thacker B. J., Holden P. J., Chang C. C., Effect of dietary Echinacea purpurea on viremia and performance in porcine reproductive and respiratory syndrome virus-infected nursery pigs Journal of Animal Science 2003 81 9 2139 2144 (Pubitemid 38571675)
117. ONeill W., McKee S., Clarke A. F., Immunologic and hematinic consequences of feeding a standardized Echinacea (Echinacea angustifolia) extract to healthy horses Equine Veterinary Journal 2002 34 3 222 227 (Pubitemid 39654991)
118. Aly S. M., Mohamed M. F., Echinacea purpurea and Allium sativum as immunostimulants in fish culture using Nile tilapia (Oreochromis niloticus) Journal of Animal Physiology and Animal Nutrition 2010 94 5 e31 e39
119. Skowronski D. M., Astell C., Brunham R. C., Low D. E., Petric M., Roper R. L., Talbot P. J., Tam T., Babiuk L., Severe acute respiratory syndrome (SARS): a year in review Annual Review of Medicine 2005 56 357 381 (Pubitemid 40299788)
120. Nicholls J. M., Butany J., Poon L. L. M., Chan K. H., Beh S. L., Poutanen S., Peiris J. S. M., Wong M., Time course and cellular localization of SARS-CoV nucleoprotein and RNA in lungs from fatal cases of SARS PLoS Medicine 2006 3, article e27
121. Frieman M., Heise M., Baric R., SARS coronavirus and innate immunity Virus Research 2008 133 1 101 112 (Pubitemid 351374752)
122. Gilroy C. M., Steiner J. F., Byers T., Shapiro H., Georgian W., Echinacea and truth in labeling Archives of Internal Medicine 2003 163 6 699 704 (Pubitemid 36343363)
123. McCann D. A., Solco A., Liu Y., Macaluso F., Murphy P. A., Kohut M. L., Senchina D. S., Cytokine- and interferon-modulating properties of Echinacea spp. root tinctures stored at -20C for 2 years Journal of Interferon and Cytokine Research 2007 27 5 425 436 (Pubitemid 46842905)
124. Hinz B., Woelkart K., Bauer R., Alkamides from Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cells Biochemical and Biophysical Research Communications 2007 360 2 441 446 (Pubitemid 47030362)
125. Schoop R., Klein P., Suter A., Johnston S. L., Echinacea in the prevention of induced rhinovirus colds: a meta-analysis Clinical Therapeutics 2006 28 2 174 183
126. Kortenkamp A., Modarai M., Silva E., Suter A., Heinrich M., Safety of herbal medicinal products: Echinacea and selected alkylamides do not induce CYP3A4 mRNA expression Evidence-Based Complementary and Alternative Medicine 2011 2011 7
127. Saunders P. R., Smith F., Schusky R. W., Echinacea purpurea L. in children: safety, tolerability, compliance, and clinical effectiveness in upper respiratory tract infections Canadian Journal of Physiology and Pharmacology 2007 85 11 1195 1199 (Pubitemid 351196417)
128. Schneider S., Reichling J., Stintzing F. C., Messerschmidt S., Meyer U., Schnitzler P., Anti-herpetic properties of hydroalcoholic extracts and pressed juice from Echinacea pallida Planta Medica 2010 76 3 265 272
129. Williamson E. M., Synergy and other interactions in phytomedicines Phytomedicine 2001 8 5 401 409 (Pubitemid 32983062)
130. Spelman K., Philosophy in phytopharmacology: Ockham's Razor versus synergy Journal of Herbal Pharmacotherapy 2005 5 2 31 47 (Pubitemid 43020041)