Echinacea extracts contain significant and selective activities against human pathogenic bacteria

Pharmaceutical Biology

Volumn 46, Issue 1-2, 2008, Pages 111-116

  Sharma, M ^a   Vohra, S ^b   Arnason, J T ^c   Hudson, J B ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Antibacterial; Bacteria; Clostridium difficile; Echinacea; Haemophilus influenzae; Human pathogens; Legionella pneumophila; Propionibacterium acne; Streptococcus pyogenes

Indexed keywords

AMIDE; CAFFEIC ACID DERIVATIVE; ECHINACEA ANGUSTIFLORA EXTRACT; ECHINACEA EXTRACT; ECHINACEA PURPUREA EXTRACT; POLYSACCHARIDE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CLOSTRIDIUM DIFFICILE; CONTROLLED STUDY; DRUG ACTIVITY; HAEMOPHILUS INFLUENZAE TYPE A; LEGIONELLA PNEUMOPHILA; NONHUMAN; PLANT ROOT; PROPIONIBACTERIUM ACNES; STREPTOCOCCUS PYOGENES;

ASTERACEAE; BACTERIA (MICROORGANISMS); CLOSTRIDIUM DIFFICILE; ECHINACEA (ASTERACEAE); ECHINACEA ANGUSTIFOLIA; ECHINACEA PURPUREA; FUNGI; HAEMOPHILUS INFLUENZAE; LEGIONELLA PNEUMOPHILA; PROPIONIBACTERIUM ACNES; STREPTOCOCCUS PYOGENES;

EID: 38849203694     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200701734919     Document Type: Article

References (25)

1. Barrett B (2003): Medicinal properties of Echinacea: A critical review. Phytomedicine 2: 66-86.
2. Bauer R (1998): Echinacea: Biological effects and active principals. Phytomedicines of Europe: Chemistry and biological activity. In: Lawson LD, Bauer R, eds. ACS Symposium Series, 691. Washington, DC, American Chemical Society, pp. 140-157.
3. Bergner P (1997): The Healing Power of Echinacea & Goldenseal. Roseville, California, Prima Lifestyle Publishing.
4. Binns SE, Livesey JF, Arnason JT, Baum BR (2002): Phytochemical variation in Echinacea from roots and flowerheads of wild and cultivated populations. J Agric Food Chem 50: 3673-3687.
5. Blumenthal M, Golberg A, Brinckmann J (2000): Herbal Medicine: Expanded Commission E Monographs. Newton, MA, Integrative Medicine Communications, pp. 88-102.
6. Brovelli EA, Rua D, Roh-Schmidt H, Chandra A, Lamont E, Noratto GD (2005): Human gene expression as a tool to determine horticultural maturity in a bioactive plant. J Agric Food Chem 53: 8156-8161.
7. Burger RA. Torres AR, Warren RP, Caldwell VD, Hughes BD (1997): Echinacea-induced cytokine production by human macrophages. Int J Immunopharmacol, 19 : 371-379.
8. Gertsch J, Schoop R, Kuenzle U, Suter A (2004): Echinacea alkylamides modulate TNF-α gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways FEBS Letters 577: 563-568.
9. Goel V, Chang C, Slama JV, Barton R, Bauer R, Gahler R (2002): Echinacea stimulates macrophage function in the lung and spleen of normal rats. J Nutr Biochem 13: 487-492.
10. Hill LL, Foote JC, Erickson BD, Cerniglia CE, Denny GS (2006): Echinacea purpurea supplementation stimulates select groups of human gastrointestinal tract microbiota. J Clin Pharm Ther 31: 599-604.
11. Hudson JB, Towers GHN (1999) Phytomedicines as antivirals. Drugs of the Future 24: 295-320.
12. Hudson J, Vimalanathan S, Kang L, Treyvaud Amiguet V, Livesey J, Arnason JT (2005): Characterization of antiviral activities in Echinacea root preparations. Pharm Biol 43: 790-796.
13. Matthias A, Banbury L, Stevenson LM, Bone KM, Leach DN, Lehmann RP (2007): Alkylamides from Echinacea modulate induced immune responses in macrophages. Immunol Inv 36: 117-130.
14. Merali S, Binns S, Paulin-Levasseur M, Ficker C, Smith M, Baum BR, Arnason JT (2003): Antifungal and anti-inflammatory activity of the genus Echinacea. Pharm Biol 41: 412-420.
15. Raduner S, Majewska, A, Chen JZ, Xie XQ, Hamon J, Faller B, Altmann KH, Gertsch J (2006): Alkylamides from Echinacea are a new class of cannabinomimetics J Biol Chem 281: 14192-14206.
16. Randolph RK, Gellenbeck K, Stonebrook K, Brovelli E, Qian Y, Bankaitis-Davis D, Cheronis J (2003): Regulation of human gene expression as influenced by a commercial blended Echinacea product: Preliminary studies. Exp Biol Med 228: 1051-1056.
17. Rininger JA, Kickner S, Chigurupati P, McLean A, Franck Z (2000): Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood cells. J Leuk Biol 68: 503-510.
18. Sharma M, Arnason JT, Burt A, Hudson JB (2006a): Echinacea extracts modulate the pattern of chemokine and cytokine secretion in rhinovirus-infected and uninfected epithelial cells Phytotherapy Res 20: 147-152.
19. Sharma M, Arnason JT, Hudson JB (2006b): Echinacea extracts modulate the production of multiple transcription factors in uninfected cells and rhinovirus-infected cells. Phytotherapy Res 20: 1074-1079.
20. Schoop R, Klein P, Suter A, Johnston SL (2006): Echinacea in the prevention of induced rhinovirus colds: A meta-analysis. Clin. Therapeutics 28: 174-183.
21. Sloley BD, Urichuk LJ, Tywin C, Coutts RT, Pang PKT, Shan JJ (2001): Comparison of chemical components and antioxidant capacity of different Echinacea species. Pharmacy Pharmacol 53: 849-857.
22. Towers GHN, Page JE, Hudson JB (1997): Light-mediated biological activities of natural products from plants and fungi. Curr Org Chem 1: 395-414.
23. Turner RB, Bauer R, Woelkart K, Hulsey TC, Gangemi JD (2005): An evaluation of Echinacea angustifolia in experimental rhinovirus infections. N Engl J Med 353: 341-348.
24. Vimalanathan S, Kang L, Treyvaud Amiguet V, Livesey J, Arnason JT, Hudson J (2005): Echinacea purpurea aerial parts contain multiple antiviral compounds. Pharm. Biol. 43: 740-745.
25. Wullt M, Odenholt I, Walder M, (2003):Activity of three disinfectants and acidified nitrite against Clostridium difficile spores. Infection Control Hosp Epidem. 24: 765-768.