Echinacea alkylamides modulate TNF-α gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways

FEBS Letters

Volumn 577, Issue 3, 2004, Pages 563-569

  Gertsch, Juerg ^a,b   Schoop, Roland ^c   Kuenzle, Urs ^a   Suter, Andy ^c  

^a ETH ZURICH   (Switzerland)

^b CH 8952   (Switzerland)

^c A Vogel Bioforce AG   (Switzerland)

Author keywords

cAMP, cyclic adenosine monophosphate; CB2, cannabinoid receptor 2; CREB 1, cAMP responsive element binding protein 1; JNK, Jun N terminal kinase; MAPK, mitogen activated protein kinase; TNF , tumor necrosis factor

Indexed keywords

AMIDE; CANNABINOID 2 RECEPTOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIENOIC ACID; ECHINACEA EXTRACT; ECHINAFORCE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRIENOIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ECHINACEA; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CELLS, CULTURED; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHINACEA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KINETICS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MACROPHAGES; MOLECULAR STRUCTURE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLANT EXTRACTS; RECEPTOR, CANNABINOID, CB2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 8844271735     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.10.064     Document Type: Article

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