TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes

Biochimica et Biophysica Acta - Biomembranes

Volumn 1798, Issue 11, 2010, Pages 2058-2066

  Gadeock, Safina ^a   Tran, Jimmy N S N ^b,c   Georgiou, Jennifer G ^b   Jalilian, Iman ^a   Taylor, Rosanne M ^c   Wiley, James S ^b,d   Sluyter, Ronald ^a,b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Inflammation; Macrophage; Monocyte; P2X receptor; Purinergic receptor; Transforming growth factor

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; ADENOSINE TRIPHOSPHATE; CD14 ANTIGEN; CD86 ANTIGEN; ETHIDIUM; GAMMA INTERFERON; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; PURINERGIC P2X7 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN; CELL STRAIN THP 1; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; LEUKEMIA CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADENOSINE TRIPHOSPHATE; ANTIGENS, CD; ANTIGENS, CD14; ANTIGENS, CD86; APYRASE; CELLS, CULTURED; HUMANS; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MONOCYTES; RECEPTORS, PURINERGIC P2; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84755161778     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2010.07.022     Document Type: Article

References (62)

1. Chen L., Brosnan C.F. Regulation of immune response by P2X7 receptor. Crit. Rev. Immunol. 2006, 26:499-513.
2. 7 in pain and inflammation. Purinergic Signal. 2007, 3:163-169.
3. 7 receptors. Am. J. Physiol. Cell Physiol. 2005, 289:C1295-C1302.
4. Schachter J., Motta A.P., de Souza Zamorano A., da Silva-Souza H.A., Guimarães M.Z., Persechini P.M. ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages. J. Cell Sci. 2008, 121:3261-3270.
5. Ferrari D., Pizzirani C., Adinolfi E., Lemoli R.M., Curti A., Idzko M., Panther E., Di Virgilio F. The P2X7 receptor: a key player in IL-1 processing and release. J. Immunol. 2006, 176:3877-3883.
6. Kono H., Rock K.L. How dying cells alert the immune system to danger. Nat. Rev. Immunol. 2008, 8:279-289.
7. la Sala A., Ferrari D., Di Virgilio F., Idzko M., Norgauer J., Girolomoni G. Alerting and tuning the immune response by extracellular nucleotides. J. Leukoc. Biol. 2003, 73:339-343.
8. Kornbluth R.S., Stone G.W. Immunostimulatory combinations: designing the next generation of vaccine adjuvants. J. Leukoc. Biol. 2006, 80:1084-1102.
9. Denlinger L.C., Coursin D.B., Schell K., Angelini G., Green D.N., Guadarrama A.G., Halsey J., Prabhu U., Hogan K.J., Bertics P.J. Human P2X7 pore function predicts allele linkage disequilibrium. Clin. Chem. 2006, 52:995-1004.
10. Stokes L., Fuller S.J., Sluyter R., Skarratt K.K., Gu B.J., Wiley J.S. Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit gain-of-function effect and enhanced interleukin-1β secretion. FASEB J. 2010, 24:2916-2967.
11. 7 receptors. Am. J. Physiol. Cell Physiol. 2000, 279:C1189-C1197.
12. 7 receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell type. Purinergic Signal. 2009, 5:385-394.
13. Hickman S.E., El Khoury J., Greenberg S., Schieren I., Silverstein S.C. P2Z adenosine triphosphate receptor activity in cultured human monocyte-derived macrophages. Blood 1994, 84:2452-2456.
14. 7 receptors. J. Invest. Dermatol. 2005, 125:482-490.
15. Blanchard D.K., McMillen S., Djeu J.Y. IFN-γ enhances sensitvity of human macrophages to extracellular ATP-mediated lysis. J. Immunol. 1991, 147:2579-2585.
16. 7 receptor function with a monoclonal antibody. Blood 1998, 92:3521-3528.
17. 7 nucleotide receptor function in human monocytes by extracellular ions and receptor density. Am. J. Physiol. Cell Physiol. 2001, 280:C943-C953.
18. 7 function by the inflammatory cytokine IFNgamma in human epithelial cells. Biochim. Biophys. Acta 2009, 1788:1176-1187.
19. Spranzi E., Djeu J.Y., Hoffman S.L., Epling-Burnette P.K., Blanchard D.K. Lysis of human monocytic leukemia cells by extracellular adenosine triphosphate: mechanism and characterization of the adenosine triphosphate receptor. Blood 1993, 82:1578-1585.
20. Humphreys B.D., Dubyak G.R. Induction of the P2Z/P2X7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and IFN-γ in the human THP-1 monocytic cell line. J. Immunol. 1996, 157:5627-5637.
21. 7 nucleotide receptor expression by pro- and anti-inflammatory stimuli in THP-1 monocytes. J. Leukoc. Biol. 1998, 64:265-273.
22. 7 nucleotide receptor: high selectivity for the human versus rat receptor homolgues. Mol. Pharmacol. 1998, 54:22-32.
23. 7. J. Leukoc. Biol. 2002, 72:222-232.
24. + release. Am. J. Physiol. Cell Physiol. 2004, 286:C1100-C1108.
25. Gu B.J., Rathsam C., Stokes L., McGeachie A.B., Wiley J.S. Extracellular ATP dissociates nonmuscle myosin from P2X7 complex: the dissociation regulates P2X7 pore formation. Am. J. Physiol. Cell Physiol. 2009, 297:430-439.
26. Gu B.J., Saunders B.M., Jursik C., Wiley J.S. The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP. Blood 2010, 115:1621-1631.
27. Grahames C.B.A., Michel A.D., Chessell I.P., Humphrey P.P.A. Pharmacological characterisation of ATP- and LPS-induced IL-1β release in human monocytes. Br. J. Pharmacol. 1999, 127:1915-1921.
28. Bachmann M., Horn K., Poleganov M.A., Paulukat J., Nold M., Pfeilschifter J., Mühl H. Interleukin-18 secretion and Th1-like cytokine responses in human peripheral blood mononuclear cells under the influence of the toll-like receptor-5 ligand flagellin. Cell. Microbiol. 2006, 8:289-300.
29. MacKenzie A., Wilson H.L., Kiss-Toth E., Dower S.K., North R.A., Surprenant A. Rapid secretion of interleukin-1β by microvesicle shedding. Immunity 2001, 8:825-835.
30. Kusner D.J., Adams J. ATP-induced killing of virulent mycobacterium tuberculosis within human macrophages requires phospholipase D. J. Immunol. 2000, 164:379-388.
31. Nelson D.W., Gregg R.J., Kort M.E., Perez-Medrano A., Voight E.A., Wang Y., Grayson G., Namovic M.T., Donnelly-Roberts D.L., Niforatos W., Honore P., Jarvis M.F., Faltynek C.R., Carroll W.A. Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J. Med. Chem. 2006, 49:3659-3666.
32. Stokes L., Jiang L.H., Alcaraz L., Bent J., Bowers K., Fagura M., Furber M., Mortimore M., Lawson M., Theaker J., Laurent C., Braddock M., Surprenant A. Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373. Br. J. Pharmacol. 2006, 149:880-887.
33. Li M.O., Wan Y.Y., Sanjabi S., Robertson A.K., Flavell R.A. Transforming growth factor-beta regulation of immune responses. Annu. Rev. Immunol. 2006, 24:99-146.
34. Dennler S., Goumans M.J., ten Dijke P. Transforming growth factor β signal transduction. J. Leukoc. Biol. 2005, 71:731-740.
35. Ronger-Savle S., Valladeau J., Claudy A., Schmitt D., Peguet-Navarro J., Dezutter-Dambuyant C., Thomas L., Jullien D. TGFβ inhibits CD1d expression on dendritic cells. J. Invest. Dermatol. 2005, 124:116-118.
36. Gomez G., Ramirez C.D., Rivera J., Patel M., Norozian F., Wright H.V., Kashyap M.V., Barnstein B.O., Fischer-Stenger K., Schwartz L.B., Kepley C.L., Ryan J.J. TGF-β1 inhibits mast cell FcεRI expression. J. Immunol. 2005, 174:5987-5993.
37. Park S.M., Kim S., Choi J.S., Hur D.Y., Lee W.J., Lee M.S., Choe J., Lee T.H. TGF-β inhibits Fas-mediated apoptosis of a follicular dendritic cell line by down-regulating the expression of Fas and caspase-8: counteracting role of TGF-β on TNF sensitization of Fas-mediated apoptosis. J. Immunol. 2005, 174:6169-6175.
38. 7 receptor: greatly increased function compared to human erythrocytes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 293:R2090-R2098.
39. Constantinescu P., Wang B., Kovacevic K., Jalilian I., Bosman G.J., Wiley J.S., Sluyter R. P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells. Biochim. Biophys. Acta 2010, 1798:1797-1804.
40. 7 receptor impairs ATP-induced IL-1β release from human monocytes. J. Immunol. 2004, 172:3399-3405.
41. 7 receptors. Exp. Dermatol. 2010, 19:e151-e157.
42. Skarratt K.K., Fuller S.J., Sluyter R., Dao-Ung L.P., Gu B.J., Wiley J.S. A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1% to 2% of the Caucasian population. FEBS Lett. 2005, 579:2675-2678.
43. Wareham K., Vial C., Wykes R.C., Bradding P., Seward E.P. Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells. Br. J. Pharmacol. 2009, 157:1215-1224.
44. Gargett C.E., Wiley J.S. The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br. J. Pharmacol. 1997, 120:1483-1490.
45. Clifford E.E., Martin K.A., Dalal P., Thomas R., Dubyak G.R. Stage-specific expression of P2Y receptors, ecto-apyrase, and ecto-5'-nucleotidase in myeloid leukocytes. Am. J. Physiol. Cell Physiol. 1997, 42:C973-C987.
46. Tamai R., Sugawara S., Takeuchi O., Akira S., Takada H. Synergistic effects of lipopolysaccharide and interferon-γ in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression. J. Endotoxin Res. 2003, 9:145-153.
47. 7 nucleotide receptor in monocytes, macrophages and HEK-293 fibroblasts. Am. J. Physiol. Cell Physiol. 2003, 285:C286-C299.
48. Dai Y., Datta S., Novotny M., Hamilton T.A. TGFβ inhibits LPS-induced chemokine mRNA stabilization. Blood 2003, 102:1178-1185.
49. Gorodeski G.I. P2X7-mediated chemoprevention of epithelial cancers. Expert Opin. Ther. Targets 2009, 13:1313-1332.
50. Yegutkin G. G., Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade. Biochim. Biophys. Acta 2008, 1783:673-694.
51. + uptake - inhibition of fluxes by suramin. Arch. Biochem. Biophys. 1993, 305:54-60.
52. 7 receptors. Int. Immunol. 2002, 14:1415-1421.
53. Panupinthu N., Rogers J.T., Zhao L., Solano-Flores L.P., Possmayer F., Sims S.M., Dixon S.J. P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. J. Cell Biol. 2008, 181:859-871.
54. Milius D., Gröger-Arndt H., Stanchev D., Lange-Dohna C., Rossner S., Sperlagh B., Wirkner K., Illes P. Oxygen/glucose deprivation increases the integration of recombinant P2X7 receptors into the plasma membrane of HEK293 cells. Toxicology 2007, 238:60-69.
55. 7 receptor. EMBO J. 2006, 25:5071-5082.
56. Miyazawa M., Ito Y., Yoshida Y., Sakaguchi H., Suzuki H. Phenotypic alterations and cytokine production in THP-1 cells in response to allergens. Toxicol. Vitro 2007, 21:428-437.
57. Tomoda T., Kurashige T., Aniguchi T. Stimulatory effect of interleukin-1β on the interferon-gamma-dependent HLA-DR production. Immunology 1992, 75:15-19.
58. Imai K., Takeshita A., Hanazawa S. Transforming growth factor-β inhibits lipopolysaccharide-stimulated expression of inflammatory cytokines in mouse macrophages through downregulation of activation protein 1 and CD14 receptor expression. Infect. Immun. 2000, 68:2418-2423.
59. Nandan D., Reiner N.E. TGF-β attenuates the class II transactivator and reveals an accessory pathway of IFN-γ action. J. Immunol. 1997, 158:1095-1101.
60. Labasi J.M., Petrushova N., Donovan C., McCurdy S., Lira P., Payette M.M., Brissette W., Wicks J.R., Audoly L., Gabel C.A. Absence of the P2X7 receptor alters leukcoyte function and attenuates an inflammatory response. J. Immunol. 2002, 168:6436-6445.
61. Fernando S.L., Saunders B.M., Sluyter R., Skarratt K.K., Goldberg H., Marks G.B., Wiley J.S., Britton W.J. A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis. Am. J. Respir. Crit. Care Med. 2007, 175:360-366.
62. Lees M.P., Fuller S.J., McLeod R., Boulter N.R., Miller C.M., Zakrzewski A.M., Mui E.J., Witola W.H., Coyne J.J., Hargrave A.C., Jamieson S.E., Blackwell J.M., Wiley J.S., Smith N.C. P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages. J. Immunol. 2010, 184:7040-7046.