Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNγ in human epithelial cells

Biochimica et Biophysica Acta - Biomembranes

Volumn 1788, Issue 5, 2009, Pages 1176-1187

  Welter Stahl, Lynn ^a   da Silva, Camila Marques ^b   Schachter, Julieta ^b   Persechini, Pedro Muanis ^b   Souza, Heitor S ^b   Ojcius, David M ^a,c   Coutinho Silva, Robson ^b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Cervical epithelial cell; Inflammation; P2X and P2Y receptors; Pro inflammatory cytokine

Indexed keywords

ADENOSINE TRIPHOSPHATE; GAMMA INTERFERON; MESSENGER RNA; PURINERGIC P2X RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL DEATH; CELL STIMULATION; CONTROLLED STUDY; EPITHELIUM CELL; HELA CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; INTESTINE EPITHELIUM CELL; ION CURRENT; MODULATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEXUAL TRANSMISSION; UPREGULATION; UTERINE CERVIX EPITHELIUM;

ADENOSINE TRIPHOSPHATE; BASE SEQUENCE; CALCIUM SIGNALING; CELL LINE; DNA PRIMERS; EPITHELIAL CELLS; HELA CELLS; HUMANS; INTERFERON-GAMMA, RECOMBINANT; ION TRANSPORT; RECEPTORS, PURINERGIC; RECEPTORS, PURINERGIC P2; RNA, MESSENGER; UP-REGULATION; URIDINE TRIPHOSPHATE;

EID: 65249157374     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2009.03.006     Document Type: Article

References (61)

1. Khakh B.S., and North R.A. P2X receptors as cell-surface ATP sensors in health and disease. Nature 442 (2006) 527-532
2. Ralevic V., and Burnstock G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50 (1998) 413-492
3. North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 82 (2002) 1013-1067
4. Erb L., Liao Z., Seye C.I., and Weisman G.A. P2 receptors: intracellular signaling. Pflugers Arch. 452 (2006) 552-562
5. Abbracchio M.P., Boeynaems J.M., Barnard E.A., Boyer J.L., Kennedy C., Miras-Portugal M.T., King B.F., Gachet C., Jacobson K.A., Weisman G.A., and Burnstock G. Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol. Sci. 24 (2003) 52-55
6. Di Virgilio F., Chiozzi P., Ferrari D., Falzoni S., Sanz J.M., Morelli A., Torboli M., Bolognesi G., and Baricordi O.R. Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97 (2001) 587-600
7. Bulanova E., Budagian V., Orinska Z., Hein M., Petersen F., Thon L., Adam D., and Bulfone-Paus S. Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells. J. Immunol. 174 (2005) 3880-3890
8. Coutinho-Silva R., Persechini P.M., Bisaggio R.C., Perfettini J.-L., Sá-Neto A.C.T., Kanellopoulos J.M., Motta-Ly I., Dautry-Varsat A., and Ojcius D.M. P2Z/P2X7 receptor-dependent apoptosis of dendritic cells. Am. J. Physiol. 276 (1999) C1139-C1147
9. Coutinho-Silva R., Stahl L., Raymond M.-N., Jungas T., Verbeke P., Burnstock G., Darville T., and Ojcius D.M. Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation. Immunity 19 (2003) 403-412
10. Coutinho-Silva R., Perfettini J.-L., Persechini P.M., Dautry-Varsat A., and Ojcius D.M. Modulation of P2Z/P2X7 receptor activity in macrophages infected with Chlamydia psittaci. Am. J. Physiol. 280 (2001) C81-C89
11. Lammas D.A., Stober C., Harvey C.J., Kendrick N., Panchalingam S., and Kumararatne D.S. ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptors. Immunity 7 (1997) 433-444
12. Fairbairn I.P., Stober C.B., Kumararatne D.S., and Lammas D.A. ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion. J. Immunol. 167 (2001) 3300-3307
13. Leipziger J. Control of epithelial transport via luminal P2 receptors. Am. J. Physiol., Renal Physiol. 284 (2003) F419-F432
14. Schwiebert E.M., and Zsembery A. Extracellular ATP as a signaling molecule for epithelial cells. Biochim. Biophys. Acta 1615 (2003) 7-32
15. Coutinho-Silva R., Stahl L., Cheung K.K., de Campos N.E., de Oliveira S.C., Ojcius D.M., and Burnstock G. P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation. Am. J. Physiol., Gastrointest. Liver Physiol. 288 (2005) G1024-G1035
16. Groschel-Stewart U., Bardini M., Robson T., and Burnstock G. P2X receptors in the rat duodenal villus. Cell Tissue Res. 297 (1999) 111-117
17. Li Q., Luo X., Zeng W., and Muallem S. Cell-specific behavior of P2X7 receptors in mouse parotid acinar and duct cells. J. Biol. Chem. 278 (2003) 47554-47561
18. Homolya L., Watt W.C., Lazarowski E.R., Koller B.H., and Boucher R.C. Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y(2) receptor (-/-) mice. J. Biol. Chem. 274 (1999) 26454-26460
19. Marino A., Rodrig Y., Metioui M., Lagneaux L., Alzola E., Fernandez M., Fogarty D.J., Matute C., Moran A., and Dehaye J.P. Regulation by P2 agonists of the intracellular calcium concentration in epithelial cells freshly isolated from rat trachea. Biochim. Biophys. Acta 1439 (1999) 395-405
20. Hopfner M., Maaser K., Barthel B., von Lampe B., Hanski C., Riecken E.O., Zeitz M., and Scherubl H. Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells: involvement of intracellular calcium and cyclic adenosine monophosphate. Int. J. Colorectal Dis. 16 (2001) 154-166
21. Maaser K., Hopfner M., Kap H., Sutter A.P., Barthel B., von Lampe B., Zeitz M., and Scherubl H. Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y(2)-receptors. Br. J. Cancer 86 (2002) 636-644
22. Kottgen M., Loffler T., Jacobi C., Nitschke R., Pavenstadt H., Schreiber R., Frische S., Nielsen S., and Leipziger J. P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport. J Clin. Invest 111 (2003) 371-379
23. Robaye B., Ghanem E., Wilkin F., Fokan D., Van Driessche W., Schurmans S., Boeynaems J.M., and Beauwens R. Loss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y(4)-null mice. Mol. Pharmacol. 63 (2003) 777-783
24. Grimm S. The art and design of genetic screens: mammalian culture cells. Nat. Rev., Genet. 5 (2004) 179-189
25. Wang Q., Wang L., Feng Y.H., Li X., Zeng R., and Gorodeski G.I. P2X7 receptor-mediated apoptosis of human cervical epithelial cells. Am. J. Physiol., Cell Physiol. 287 (2004) C1349-C1358
26. Wang Q., Li X., Wang L., Feng Y.H., Zeng R., and Gorodeski G. Antiapoptotic effects of estrogen in normal and cancer human cervical epithelial cells. Endocrinology 145 (2004) 5568-5579
27. Wang L., Feng Y.H., and Gorodeski G.I. Epidermal growth factor facilitates epinephrine inhibition of P2X7-receptor-mediated pore formation and apoptosis: a novel signaling network. Endocrinology 146 (2005) 164-174
28. Fischer S.F., Vier J., Kirschnek S., Klos A., Hess S., Ying S., and Hacker G. Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins. J. Exp. Med. 200 (2004) 905-916
29. Tang P., Sutherland C.L., Gold M.R., and Finlay B.B. Listeria monocytogenes invasion of epithelial cells requires the MEK-1/ERK-2 mitogen-activated protein kinase pathway. Infect. Immun. 66 (1998) 1106-1112
30. Coombes B.K., Wickham M.E., Lowden M.J., Brown N.F., and Finlay B.B. Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 17460-17465
31. Martinez J.J., Seveau S., Veiga E., Matsuyama S., and Cossart P. Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii. Cell 123 (2005) 1013-1023
32. Veiga E., and Cossart P. Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells. Nat. Cell Biol. 7 (2005) 894-900
33. Muscella A., Elia M.G., Greco S., Storelli C., and Marsigliante S. Activation of P2Y2 purinoceptor inhibits the activity of the Na+/K+-ATPase in HeLa cells. Cell. Signal. 15 (2003) 115-121
34. Muscella A., Greco S., Elia M.G., Storelli C., and Marsigliante S. Differential signalling of purinoceptors in HeLa cells through the extracellular signal-regulated kinase and protein kinase C pathways. J. Cell. Physiol. 200 (2004) 428-439
35. Feng Y.H., Li X., Wang L., Zhou L., and Gorodeski G.I. A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization. J Biol. Chem. 281 (2006) 17228-17237
36. Lad S.P., Fukuda E.Y., Li J., de la Maza L.M., and Li E. Up-regulation of the JAK/STAT1 signal pathway during Chlamydia trachomatis infection. J. Immunol. 174 (2005) 7186-7193
37. Fichorova R.N., Desai P.J., Gibson III F.C., and Genco C.A. Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cells. Infect. Immun. 69 (2001) 5840-5848
38. Rasmussen S.J., Eckmann L., Quayle A.J., shen L., Zhang Y.X., Anderson D.J., Fierer J., Stephens R.S., and Kagnoff M.F. Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J. Clin. Invest. 99 (1997) 77-87
39. Perfettini J.L., Gissot M., Souque P., and Ojcius D.M. Modulation of apoptosis during infection with Chlamydia. Methods Enzymol. 358 (2002) 334-344
40. Hamill O.P., Marty A., Neher E., Sakmann B., and Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Eur. J. Physiol. 391 (1981) 85-100
41. Morelli A., Ferrari D., Bolognesi G., Rizzuto R., and Di Virgilio F. Proapoptotic plasma membrane pore: P2X7 receptor. Drug Dev. Res. 52 (2001) 571-578
42. Humphreys B.D., and Dubyak G.R. Modulation of P2X7 nucleotide receptor expression by pro- and anti-inflammatory stimuli in THP-1 monocytes. J. Leukoc. Biol. 64 (1998) 265-273
43. 7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and IFN-gamma in the human THP-1 monocytic cell line. J. Immunol. 157 (1996) 5627-5637
44. Persechini P.M., Bisaggio R.C., Alves-Neto J.L., and Coutinho-Silva R. Extracellular ATP in the lymphohematopoietic system: P2Z purinoceptors and membrane permeabilization. Braz. J. Med. Biol. Res. 31 (1998) 25-34
45. Albuquerque C., Oliveira S.M., Coutinho-Silva R., Oliveira-Castro G.M., and Persechini P.M. ATP- and UTP-induced currents in macrophages and macrophage-polykaryons. Am. J. Physiol. 265 (1993) C1663-C1673
46. Coutinho-Silva R., Ojcius D.M., Gorecki D.C., Persechini P.M., Bisaggio R.C., Mendes A.N., Marks J., Burnstock G., and Dunn P.M. Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages. Biochem. Pharmacol. 69 (2005) 641-655
47. Coutinho-Silva R., da Cruz C.M., Persechini P.M., and Ojcius D.M. The role of P2 receptors in controlling infections by intracellular pathogens. Purinergic Signalling 3 (2007) 83-90
48. Ferrari D., Pizzirani C., Adinolfi E., Lemoli R.M., Curti A., Idzko M., Panther E., and Di Virgilio F. The P2X7 receptor: a key player in IL-1 processing and release. J. Immunol. 176 (2006) 3877-3883
49. Bours M.J., Swennen E.L., Di Virgilio F., Cronstein B.N., and Dagnelie P.C. Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol. Ther. 112 (2006) 358-404
50. Gallucci S., and Matzinger P. Danger signals: SOS to the immune system. Curr. Opin. Immunol. 13 (2001) 114-119
51. Aswad F., Kawamura H., and Dennert G. High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors. J. Immunol. 175 (2005) 3075-3083
52. Labasi J.M., Petrushova N., Donovan C., McCurdy S., Lira P., Payette M.M., Brissette W., Wicks J.R., Audoly L., and Gabel C.A. Absence of the P2X(7) receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol. 168 (2002) 6436-6445
53. Kawamura H., Aswad F., Minagawa M., Govindarajan S., and Dennert G. P2X7 receptors regulate NKT cells in autoimmune hepatitis. J. Immunol. 176 (2006) 2152-2160
54. Chen L., and Brosnan C.F. Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes. J. Immunol. 176 (2006) 3115-3126
55. Adinolfi E., Pizzirani C., Idzko M., Panther E., Norgauer J., Di Virgilio F., and Ferrari D. P2X7 receptor: death or life?. Purinergic Signalling 1 (2005) 219-227
56. Gudipaty L., Humphreys B.D., Buell G., and Dubyak G.R. Regulation of P2X(7) nucleotide receptor function in human monocytes by extracellular ions and receptor density. Am. J. Physiol. 280 (2001) C943-C953
57. Burnstock G., and Knight G.E. Cellular distribution and functions of P2 receptor subtypes in different systems. Int. Rev. Cyt. 240 (2004) 31-304
58. Muscella A., Elia M.G., Greco S., Storelli C., and Marsigliante S. Activation of P2Y2 receptor induces c-FOS protein through a pathway involving mitogen-activated protein kinases and phosphoinositide 3-kinases in HeLa cells. J. Cell. Physiol. 195 (2003) 234-240
59. Kennedy C., Qi A.D., Herold C.L., Harden T.K., and Nicholas R.A. ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. Mol. Pharmacol. 57 (2000) 926-931
60. Lich J.D., Arthur J.C., and Ting J.P. Cryopyrin: in from the cold. Immunity 24 (2006) 241-243
61. Meylan E., Tschopp J., and Karin M. Intracellular pattern recognition receptors in the host response. Nature 442 (2006) 39-44