Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 718-722

  McNulty, James ^a   Nair, Jerald J ^a   Vurgun, Nesrin ^a   Difrancesco, Benjamin R ^a   Brown, Carla E ^a   Tsoi, Bernice ^a   Crankshaw, Denis J ^a   Holloway, Alison C ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Aldol reaction; Anticancer compounds; Aromatase inhibition; Triazoles

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; ALDEHYDE; AMINOGLUTETHIMIDE; ANASTROZOLE; APIGENIN; AROMATASE; AROMATASE INHIBITOR; EXEMESTANE; ISOQUINOLINE DERIVATIVE; KETOCONAZOLE; LETROZOLE; NARCICLASINE; PANCRATISTATIN; PHENYLACETIC ACID DERIVATIVE; TAMOXIFEN; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CONTROLLED STUDY; CYCLOADDITION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; FIVE COMPONENT SYNTHESIS; HUMAN; HUMAN CELL; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALDEHYDES; ANTINEOPLASTIC AGENTS; AROMATASE; AROMATASE INHIBITORS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHENYLACETATES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84655167812     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.039     Document Type: Article

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