Structure activity studies on the crinane alkaloid apoptosis-inducing pharmacophore

Natural Product Communications

Volumn 4, Issue 4, 2009, Pages 483-488

  McNulty, James ^a   Nair, Jerald J ^a   Bastida, Jaume ^b   Pandey, Siyaram ^c   Griffin, Carly ^c  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF WINDSOR   (Canada)

Author keywords

Alkaloid; Amaryllidaceae; Apoptosis; Crinane; Cytotoxicity

Indexed keywords

ALCOHOL; ALKALOID DERIVATIVE; ALPHA ETHANO BRIDGED; CARBON 11; CRINAMINE; CRINANE ALKANOID; DIHYDROCRINAMINE; DIHYDROHAMAYNE; HAEMANTHAMINE; HAMAYNE; HYDROGEN; HYDROXYL GROUP; PANCRATISTATIN; UNCLASSIFIED DRUG; VITTATINE; AMARYLLIDACEAE ALKALOID; CASPASE 3; CRINANE; PHENANTHRIDINE DERIVATIVE; PLANT EXTRACT;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL BOND; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; HYDROGEN BOND; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; HYDROGENATION; LEUKEMIA CELL LINE; METABOLISM;

AMARYLLIDACEAE;

AMARYLLIDACEAE ALKALOIDS; APOPTOSIS; CASPASE 3; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; HYDROGENATION; JURKAT CELLS; PHENANTHRIDINES; PLANT EXTRACTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65749095009     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0900400408     Document Type: Article

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