Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2335-2339

  McNulty, James ^a   Nair, Jerald J ^a   Singh, Mohini ^a   Crankshaw, Denis J ^a   Holloway, Alison C ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Anticancer agent; Antifungal; Antioxidant; Human cytochrome; P450 3A4; Pancratistatin

Indexed keywords

AMARYLLIDACEAE ALKALOID; ANTINEOPLASTIC AGENT; CRINAMINE; CRININE; CYTOCHROME P450 3A4; GALANTAMINE; HOMOLYCORINE; LYCORINE; MONTANINE; NARCICLASINE; NORBELLADINE; PANCRATISTATIN; TAZETTINE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; BIOTRANSFORMATION; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

AMARYLLIDACEAE ALKALOIDS; CYTOCHROME P-450 CYP3A; HUMANS; ISOQUINOLINES; LILIACEAE; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949488021     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.157     Document Type: Article

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