Down-regulation of Homer1b/c attenuates glutamate-mediated excitotoxicity through endoplasmic reticulum and mitochondria pathways in rat cortical neurons

Free Radical Biology and Medicine

Volumn 52, Issue 1, 2012, Pages 208-217

  Chen, Tao ^a,c   Fei, Fei ^b   Jiang, Xiao Fan ^a   Zhang, Lei ^a   Qu, Yan ^a   Huo, Kai ^a   Fei, Zhou ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c The 123th Hospital of PLA   (China)

Author keywords

Endoplasmic reticulum; Excitotoxicity; Homer; Mitochondria; Reactive oxygen species

Indexed keywords

BETA ACTIN; CALCIUM; CASPASE 12; CASPASE 3; CASPASE 9; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GLUTAMIC ACID; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; METABOTROPIC RECEPTOR 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN HOMER 1B; PROTEIN HOMER 1C; PROTEIN KINASE; PROTEIN PERK; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN MITOCHONDRION; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; ENZYME RELEASE; EXCITOTOXICITY; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CARRIER PROTEINS; CASPASE 12; CELL SURVIVAL; CEREBRAL CORTEX; DOWN-REGULATION; EIF-2 KINASE; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GLUTAMIC ACID; HEAT-SHOCK PROTEINS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEURONS; PRIMARY CELL CULTURE; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

EUKARYOTA; RATTUS;

EID: 84655167207     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.10.451     Document Type: Article

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