Homer: A link between neural activity and glutamate receptor function

Current Opinion in Neurobiology

Volumn 10, Issue 3, 2000, Pages 370-374

  Xiao, Bo ^a   Cheng Tu, Jian ^a   Worley, Paul F ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; INOSITOL TRISPHOSPHATE; METABOTROPIC RECEPTOR; RYANODINE RECEPTOR;

NERVE CELL; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION; SYNAPTOGENESIS;

EID: 0342313718     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(00)00087-8     Document Type: Review

References (42)

1. ••] defines the link between Shank and Homer.
2. ••].
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4. Ciruela F., Soloviev M.M., Chan W.Y., McIlhinney R.A. Homer-1c/Vesl-1L modulates the cell surface targeting of metabotropic glutamate receptor type 1α: evidence for an anchoring function. Mol Cell Neurosci. 15:2000;36-50.
5. Roche K.W., Tu J.C., Petralia R.S., Xiao B., Wenthold R.J., Worley P.F. Homer 1b regulates the trafficking of group I metabotropic glutamate receptors. J Biol Chem. 274:1999;25953-25957. Presents an initial report of the effect of Homer on mGluR trafficking. CC-Homers cause the retention of group 1 mGluRs in the ER, whereas Homer 1a is permissive for insertion of the mature receptor into the plasma membrane. The action of CC-Homer requires direct protein-protein interaction with the receptor. Extensive pools of ER-associated mGluRs are demonstrated in CNS neurons, suggesting that Homer may play a similar 'receptor trafficking' role in in vivo systems.
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14. Xiao B., Tu J.C., Petralia R.S., Yuan J., Doan A., Breder C., Ruggiero A., Lanahan A.A., Wenthold R.J., Worley P.F. Homer regulates the association of group 1 metabotropic receptors with multivalent complexes of Homer-related, synaptic proteins. Neuron. 21:1998;707-716. Describes the extended family of Homer/Vesl proteins and the current Homer nomenclature. CC-Homer proteins are visualized at the PSD and are demonstrated to self associate in vivo. Transgenic mice that overexpress Homer 1a demonstrate its ability to regulate the coupling of CC-Homer to group 1 mGluRs.
15. Beneken J., Tu J.C., Xiao B., Nuriya M., Yuan J.P., Worley P.F., Leahy D.J. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron. 26:2000;143-154. Presents the structure of the Homer EVH1 domain, which elucidates the distinctive binding properties of the Homer subfamily. Mena/VASP EVH1 domains bind FPPPP, whereas Homer EVH1 binds PPXXF. The orientation of the peptides as they are bound to their respective EVH1 domains is identical, and binding specificity is conferred by distinct pockets for the phenylalanine.
16. Tadokoro S., Tachibana T., Imanaka T., Nishida W., Sobue K. Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering. Proc Natl Acad Sci USA. 96:1999;13801-13806. The self-association properties of the Homer CC domain are examined and shown to be mediated by several different domains. This article anticipates the complexity of CC-Homer self-multimerization.
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