Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells

British Journal of Pharmacology

Volumn 135, Issue 8, 2002, Pages 1959-1966

  Oka, Tatsuya ^a   Sato, Koichi ^a   Hori, Masatoshi ^a   Ozaki, Hiroshi ^a   Karaki, Hideaki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Calcium; Capacitative calcium entry; Degranulation; DNP HSA; Inositol 1,4,5 triphosphate; RBL 2H3 mast cells; Xestospongin C; escin

Indexed keywords

2,4 DINITROPHENOL; BETA ESCIN; BETA N ACETYLHEXOSAMINIDASE; CALCIUM ION; DINITROPHENYL ANTIBODY; FC RECEPTOR; FURAPTRA; HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN E; INOSITOL 1,4,5 TRIPHOSPHATE RECEPTOR BLOCKING AGENT; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; RECEPTOR BLOCKING AGENT; THAPSIGARGIN; UNCLASSIFIED DRUG; XESTOSPONGIN C;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CAPACITATIVE CALCIUM ENTRY; CONTROLLED STUDY; CYTOSOL; DEGRANULATION; DRUG ACTIVITY; DRUG MECHANISM; DRUG SELECTIVITY; ENDOPLASMIC RETICULUM; INHIBITION KINETICS; MAST CELL DEGRANULATION; MEMBRANE PERMEABILITY; NONHUMAN; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RAT; RECEPTOR BLOCKING; TRANSPORT KINETICS;

ANIMALS; BETA-N-ACETYLHEXOSAMINIDASE; CALCIUM; CALCIUM CHANNELS; CELL DEGRANULATION; CELL MEMBRANE PERMEABILITY; CYTOSOL; DINITROPHENOLS; ENDOPLASMIC RETICULUM; ESCIN; HAPTENS; INOSITOL 1,4,5-TRISPHOSPHATE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MACROCYCLIC COMPOUNDS; MAST CELLS; OXAZOLES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SERUM ALBUMIN; TUMOR CELLS, CULTURED;

EID: 0036256558     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704662     Document Type: Article

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