Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity

Free Radical Biology and Medicine

Volumn 48, Issue 5, 2010, Pages 727-735

  Shen, Yao ^a,b   He, Ping ^b   Fan, Yan ying ^b   Zhang, Jian xiang ^b   Yan, Hai jing ^b   Hu, Wei wei ^b   Ohtsu, Hiroshi ^c   Chen, Zhong ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Brain; Carnosine; Free radicals; Glutamate transporter 1; Ischemia; Mitochondrial function

Indexed keywords

ALPHA FLUOROMETHYLHISTIDINE; CARNOSINE; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMIC ACID; HISTIDINE DECARBOXYLASE; N METHYL DEXTRO ASPARTIC ACID; REACTIVE OXYGEN METABOLITE; ROTENONE; VESICULAR GLUTAMATE TRANSPORTER 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BLOOD PH; BLOOD PRESSURE MEASUREMENT; BODY TEMPERATURE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CARBON DIOXIDE TENSION; CELL STRAIN; CONTROLLED STUDY; DRUG MECHANISM; EXCITOTOXICITY; HEART RATE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEUROPROTECTION; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; APOPTOSIS; ASTROCYTES; CARNOSINE; GLUTAMIC ACID; HISTIDINE DECARBOXYLASE; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; PC12 CELLS; RATS; REACTIVE OXYGEN SPECIES; ROTENONE;

MUS;

EID: 75149122735     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.12.021     Document Type: Article

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