Snailase preparation of ginsenoside M1 from protopanaxadiol-type ginsenoside and their protective effects against CCl 4-induced chronic hepatotoxicity in mice

Molecules

Volumn 16, Issue 12, 2011, Pages 10093-10103

  Li, Wei ^a,b   Zhang, Ming ^a   Zheng, Yi Nan ^b   Li, Jing ^a   Wang, Ying Ping ^c   Wang, Yun Jing ^a   Gu, Jian ^a   Jin, Ying ^d   Wang, Hui ^d   Chen, Li ^a  

^a Basic Medical College   (China)

^b JILIN AGRICULTURAL UNIVERSITY   (China)

^c INSTITUTE OF PLANT PROTECTION   (China)

^d JILIN UNIVERSITY   (China)

Author keywords

Ginsenoside M1; Hepatoprotective effect; Protopanaxadiol type ginsenoside

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; GINSENOSIDE; GINSENOSIDE M1; MALONALDEHYDE; PROTECTIVE AGENT; PROTOPANAXADIOL; SAPOGENIN; SUPEROXIDE DISMUTASE; TISSUE EXTRACT;

ANIMAL; ARTICLE; BIOTRANSFORMATION; BLOOD; BODY WEIGHT; CHEMISTRY; CHRONIC DISEASE; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; MALE; METABOLISM; MOUSE; ORGAN SIZE; PATHOLOGY; SNAIL; TOXIC HEPATITIS;

ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; BIOTRANSFORMATION; BODY WEIGHT; CARBON TETRACHLORIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHRONIC DISEASE; DRUG-INDUCED LIVER INJURY; GINSENOSIDES; LIVER; MALE; MALONDIALDEHYDE; MICE; MICE, INBRED ICR; ORGAN SIZE; PROTECTIVE AGENTS; SAPOGENINS; SNAILS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUPEROXIDE DISMUTASE; TISSUE EXTRACTS;

EID: 84555188080     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules161210093     Document Type: Article

References (28)

1. Xu, G.S.; Liu, H.N.; Li, J.; Wu, X.L.; Dai, X.M.; Liu, Y.H. Hepatic injury induced by carbon dioxide pneumoperitoneum in experimental rats. World J. Gastroenterol. 2009, 15, 3060-3064.
2. Bleibel, W.; Kim, S.; D'Silva, K.; Lemmer, E.R. Drug-induced liver injury: Review article. Dig. Dis. Sci. 2007, 52, 2463-2471. (Pubitemid 47373878)
3. Benjamin, S.B.; Ishak, K.G.; Zimmerman, H.J.; Grushka, A. Phenylbutazone liver injury: A clinical-pathologic survey of 23 cases and review of the literature. Hepatology 1981, 1, 255-263. (Pubitemid 11003581)
4. Au, J.S.; Navarro, V.J.; Rossi, S. Review article: Drug-induced liver injury-Its pathophysiology and evolving diagnostic tools. Aliment. Pharmacol. Ther. 2011, 34, 11-20.
5. Tipoe, G.L.; Leung, T.M.; Liong, E.C.; Lau, T.Y.; Fung, M.L.; Nanji, A.A. Epigallocatechin-3- gallate (EGCG) reduces liver inflammation. oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice. Toxicology 2010, 273, 45-52.
6. Yoshikawa, M.; Ninomiya, K.; Shimoda, H.; Nishida, N.; Matsuda, H. Hepatoprotective and antioxidative properties of Salacia reticulata: Preventive effects of phenolic constituents on CCl4-induced liver injury in mice. Biol. Pharm. Bull. 2002, 25, 72-76.
7. 4-intoxicated mice. Toxicology 2011, 280, 33-43.
8. Yang, L.; Wang, C.Z.; Ye, J.Z.; Li, H.T. Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats. Fitoterapia 2011, 82, 834-840.
9. Yurt, B.; Celik, I. Hepatoprotective effect and antioxidant role of sun, sulphited-dried apricot (Prunus armeniaca L.) and its kernel against ethanol-induced oxidative stress in rats. Food Chem. Toxicol. 2011, 49, 508-513.
10. Lin, H.J.; Chen, J.Y.; Lin, C.F.; Kao, S.T.; Cheng, J.C.; Chen, H.L.; Chen, C.M. Hepatoprotective effects of Yi Guan Jian, an herbal medicine, in rats with dimethylnitrosamine-induced liver fibrosis. J. Ethnopharmacol. 2011, 134, 953-960.
11. Qi, L.W.; Wang, C.Z.; Yuan, C.S. Isolation and analysis of ginseng: Advances and challenges. Nat. Prod. Rep. 2011, 28, 467-495.
12. Wakabayashi, C.; Hasegawa, H.; Murata, J.; Saiki, I. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol. Res. 1997, 9, 411-417. (Pubitemid 127825994)
13. Akao, T.; Kida, H.; Kanaoka, M.; Hattori, M.; Kobashi, K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J. Pharm. Pharmacol. 1998, 50, 1155-1160. (Pubitemid 28488135)
14. Lee, I.K.; Kang, K.A.; Lim, C.M.; Kim, K.C.; Kim, H.S.; Kim, D.H.; Kim, B.J.; Chang, W.Y.; Choi, J.H.; Hyun, J.W. Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells. Int. J. Mol. Sci. 2010, 11, 4916-4931.
15. Kim, D.Y.; Park, M.W.; Yuan, H.D.; Lee, H.J.; Kim, S.H.; Chung, S.H. Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells. J. Agric. Food Chem. 2009, 57, 10573-10578.
16. Joh, E.H.; Lee, I.A.; Jung, I.H.; Kim, D.H. Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation-The key step of inflammation. Biochem. Pharmacol. 2011, 82, 278-286.
17. Yoon, S.H.; Han, E.J.; Sung, J.H.; Chung, S.H. Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice. Biol. Pharm. Bull. 2007, 30, 2196-2200. (Pubitemid 350097050)
18. Kim, D.Y.; Yuan, H.D.; Chung, I.K.; Chung, S.H. Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells. J. Agric. Food Chem. 2009, 57, 1532-1537.
19. Han, B.H.; Park, M.H.; Han, Y.N.; Woo, L.K.; Sankawa, U.; Yahara, S.; Tanaka, O. Degradation of ginseng saponins under mild acidic conditions. Planta Med. 1982, 44, 146-149. (Pubitemid 12101117)
20. Bae, E.A.; Han, M.J.; Choo, M.K.; Park, S.Y.; Kim, D.H. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol. Pharm. Bull. 2002, 25, 58-63.
21. 2, Rc and Rd by novel ?-glucosidase hydrolyzing outer 3-O glycoside from Sphingomonas sp. 2F2. Cloning, expression, and enzyme characterization. J. Biotechnol. 2011, 156, 125-133.
22. You, J.Y.; Peng, C.; Liu, X.; Ji, X.J.; Lu, J.; Tong, Q.; Wei, P.; Cong, L.; Li, Z.; Huang, H. Enzymatic hydrolysis and extraction of arachidonic acid rich lipids from Mortierella alpina. Bioresour. Technol. 2011, 102, 6088-6094.
23. Liu, X.; Cui, Y.; Yang, L.; Yang, S.L. Purification of a ginsenoside-Rb1 hydrolase from Helix snailase. Sheng Wu Gong Cheng Xue Bao 2005, 21, 929-933.
24. Park, E.J.; Zhao, Y.Z.; Kim, J.; Sohn, D.H. A ginsenoside metabolite, 20-O-beta-Dglucopyranosyl- 20(S)-protopanaxadiol, triggers apoptosis in activated rat hepatic stellate cells via caspase-3 activation. Planta Med. 2006, 72, 1250-1253. (Pubitemid 44759240)
25. Liu, R.; Zhang, J.Z.; Liu, W.C.; Kimura, Y.; Zheng, Y.N. Anti-obesity effects of protopanaxdiol types of ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet. Fitoterapia 2010, 81, 1079-1087.
26. Sigala, F.; Kostopanagiotou, G.; Andreadou, I.; Kavatzas, N.; Felekouras, E.; Sigalas, P.; Bastounis, E.; Papalambros, E. Histological and lipid peroxidation changes after administration of 2-acetylaminofluorene in a rat liver injury model following selective periportal and pericentral damage. Toxicology 2004, 196, 155-163. (Pubitemid 38220897)
27. 3- and ethanol-induced liver injury. Toxicol. Appl. Pharmacol. 1977, 42, 463-475. (Pubitemid 8270232)
28. Quan, L.H.; Cheng, L.Q.; Kim, H.B.; Kim, J.H.; Son, N.R.; Kim, S.Y.; Jin, H.O.; Yang, D.C. Bioconversion of Ginsenoside Rd into Compound K by Lactobacillus pentosus DC101 Isolated from Kimchi. J. Ginseng Res. 2010, 34, 288-295.