Osteoblastic cells have refractory periods for fluid-flow-induced intracellular calcium oscillations for short bouts of flow and display multiple low-magnitude oscillations during long-term flow

Journal of Biomechanics

Volumn 36, Issue 1, 2003, Pages 35-43

  Donahue, Seth W ^a   Donahue, Henry J ^b   Jacobs, Christopher R ^c,d  

^a 815 RL Smith ME EM Building   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^d Stanford University   (United States)

Author keywords

Bone adaptation; Calcium signaling; Mechanotransduction; Oscillating fluid flow; Osteoblast

Indexed keywords

BONE; CALCIUM; FLOW OF FLUIDS; GENES; OSCILLATIONS; SHEAR STRESS;

CELLULAR ACTIVITIES;

BIOMECHANICS;

CALCIUM ION;

ANIMAL CELL; ARTICLE; BONE CELL; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL ACTIVITY; CONTROLLED STUDY; FLOW; FLUID FLOW; GENE EXPRESSION; LONG BONE; NONHUMAN; OSCILLATION; OSTEOBLAST; PRIORITY JOURNAL; RAT; REFRACTORY PERIOD; SHEAR STRESS; TIME;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; HUMANS; MECHANOTRANSDUCTION, CELLULAR; OSTEOBLASTS; PERIODICITY; PHYSICAL STIMULATION; PRESSURE; RATS; RATS, INBRED F344; REPRODUCIBILITY OF RESULTS; RHEOLOGY; SENSITIVITY AND SPECIFICITY; SHEAR STRENGTH; STRESS, MECHANICAL; TIME FACTORS;

EID: 0037212138     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9290(02)00318-4     Document Type: Article

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