The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor

EMBO Journal

Volumn 21, Issue 16, 2002, Pages 4259-4267

  Stockinger, Walter ^b   Sailler, Beate ^a   Strasser, Vera ^a   Recheis, Burgi ^a   Fasching, Daniela ^a   Kahr, Larissa ^a   Schneider, Wolfgang J ^a   Nimpf, Johannes ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Adaptor proteins; Endocytosis; LDL receptor family; SNX17

Indexed keywords

ADAPTOR PROTEIN; APOLIPOPROTEIN E2; LOW DENSITY LIPOPROTEIN RECEPTOR; PHOSPHATIDYLINOSITIDE; PROTEIN SNX17; RHODAMINE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL CELL; ARTICLE; CELL MEMBRANE TRANSPORT; ENDOCYTOSIS; ENDOSOME; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING;

ANIMALS; CARRIER PROTEINS; CELL LINE; ENDOCYTOSIS; FLUORESCENT ANTIBODY TECHNIQUE; LDL-RECEPTOR RELATED PROTEIN 2; MICE; NERVE TISSUE PROTEINS; RECEPTORS, LDL; RECEPTORS, LIPOPROTEIN; RECOMBINANT PROTEINS; VESICULAR TRANSPORT PROTEINS;

ANIMALIA;

EID: 0037102292     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf435     Document Type: Article

References (42)

1. Avian and murine LR8B and human apolipoprotein E receptor 2: Differentially spliced products from corresponding genes
2. 2-macroglobulin
3. Rab7: A key to lysosome biogenesis
4. Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes
5. The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis
6. A new member of the sorting nexin family interacts with the C-terminus of P-selectin
7. Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein
8. Receptors of the low density lipoprotein (LDL) receptor family in man. Multiple functions of the large family members via interaction with complex ligands
9. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
10. Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction
11. The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes
12. Identification of a family of sorting nexin molecules and characterization of their association with receptors
13. Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140
14. The LDL receptor gene family: (Un)expected signal transducers in the brain
15. The chicken oocyte receptor for yolk precursors as model to study the action of receptor associated protein and lactoferrin
16. The LDL receptor gene family: Signaling functions during development
17. The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids
18. Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptor and LDL receptor-related protein (LRP)
19. Enhanced degradation of EGF receptors by a sorting nexin, SNX1
20. Self-assembly and binding of a sorting nexin to sorting endosomes
21. Leukocyte-endothelial cell interactions
22. Leukocyte trafficking mediated by selectin-carbohydrate interactions
23. Applications of interaction traps/two-hybrid systems to biotechnology research
24. The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins
25. From cholesterol transport to signal transduction: Low density lipoprotein receptor, very low density lipoprotein receptor and apolipoprotein E receptor-2
26. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement)
27. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3
28. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-β family of receptor serine-threonine kinases
29. Novel domains in NADPH oxidase subunits, sorting nexins and PtdIns 3-kinases: Binding partners of SH3 domains?
30. Role of the reelin signaling pathway in central nervous development
31. The low density lipoprotein receptor
32. Oocyte growth in the chicken: Receptors and more
33. Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5 and Rab11
34. 2-macroglobulin receptors in the brain
35. The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
36. LDL receptor-related protein: A multiligand receptor for lipoprotein and proteinase catabolism
37. Interaction of cytosolic adaptor proteins with neuronal apoE receptors and the amyloid presursor proteins
38. Reeler/disabled-like disruption of neuronal migartion in knock out mice lacking the VLDL receptor and apoE receptor-2
39. The low-density lipoprotein receptor gene family: Multiple roles in lipid metabolism
40. Phoxy lipids. Revealing PX domains as phosphoinositide binding modules
41. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P
42. Endosomal localization and function of sorting nexin 1