Yeast two-hybrid screens imply involvement of fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport

Experimental Cell Research

Volumn 289, Issue 2, 2003, Pages 211-221

  Reuter, Tanja Y ^a   Medhurst, Annette L ^b   Waisfisz, Quinten ^c   Zhi, Yu ^d   Herterich, Sabine ^a   Hoehn, Holger ^a   Gross, Hans J ^a   Joenje, Hans ^c   Hoatlin, Maureen E ^d   Mathew, Christopher G ^b   Huber, Pia A J ^b,e  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b GUY S HOSPITAL   (United Kingdom)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTIZYME; ATM PROTEIN; BRCA1 PROTEIN; CYCLIN DEPENDENT KINASE 2; DEATH DOMAIN ASSOCIATED PROTEIN XX; DNA POLYMERASE; ENOLASE; FANCONI ANEMIA PROTEIN; FANCONI ANEMIA ZINC FINGER PROTEIN; FRUCTOSE BISPHOSPHATE ALDOLASE; GUANINE NUCLEOTIDE BINDING PROTEIN; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; I KAPPA B; KERATIN; LAMININ BINDING PROTEIN; POLYPEPTIDE; PROTEASOME; PROTEIN; PROTEIN KINASE; PROTEIN KINASE B; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RAN PROTEIN; STAT1 PROTEIN; TRANSPOSASE; UBIQUITIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

AEROBIC METABOLISM; ANALYTIC METHOD; ARTICLE; CELL TRANSPORT; CELLULAR PARAMETERS; DNA LIBRARY; DNA SCREENING; IMMUNOPRECIPITATION; INTRACELLULAR TRANSPORT; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UNINDEXED SEQUENCE; YEAST TWO HYBRID SYSTEM;

EID: 0141788633     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4827(03)00261-1     Document Type: Article

References (57)

1. Auerbach A.D., Adler B., Chaganti R.S. Prenatal and postnatal diagnosis and carrier detection of Fanconi anemia by a cytogenetic method. Pediatrics. 67:1981;128-135.
2. Joenje H., Patel K.J. The emerging genetic and molecular basis of Fanconi anaemia. Nat. Rev. Genet. 2:2001;446-457.
3. Timmers C., Taniguchi T., Hejna J., Reifsteck C., Lucas L., Bruun D., Thayer M., Cox B., Olson S., D'Andrea A.D., Moses R., Grompe M. Positional cloning of a novel Fanconi anemia gene, FANCD2. Mol. Cell. 7:2001;241-248.
4. Howlett N.G., Taniguchi T., Olson S., Cox B., Waisfisz Q., De Die-Smulders C., Persky N., Grompe M., Joenje H., Pals G., Ikeda H., Fox E.A., D'Andrea A.D. Biallelic inactivation of BRCA2 in Fanconi anemia. Science. 297:2002;606-609.
5. Garcia-Higuera I., Taniguchi T., Ganesan S., Meyn M.S., Timmers C., Hejna J., Grompe M., D'Andrea A.D. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell. 7:2001;249-262.
6. Auerbach A.D., Buchwald M., Joenje H. Fanconi anemia. Kinzler V. The Genetic Basis of Human Cancer. 1998;McGraw-Hill Inc, New York.
7. Ahmad S.I., Hanaoka F., Kirk S.H. Molecular biology of Fanconi anaemia - an old problem, a new insight. BioEssays. 24:2002;439-448.
8. Wong J.C., Buchwald M. Disease model Fanconi anemia . Trends Mol. Med. 8:2002;139-142.
9. Fields S., Sternglanz R. The two-hybrid system an assay for protein-protein interactions . Trends Genet. 10:1994;286-292.
10. Fields S., Song O. A novel genetic system to detect protein-protein interactions. Nature. 340:1989;245-246.
11. Sharan S.K., Bradley A. Functional characterization of BRCA1 and BRCA2 clues from their interacting proteins . J. Mammary Gland Biol. Neoplasia. 3:1998;413-421.
12. Walhout A.J., Sordella R., Lu X., Hartley J.L., Temple G.F., Brasch M.A., Thierry-Mieg N., Vidal M. Protein interaction mapping in C. elegans using proteins involved in vulval development. Science. 287:2000;116-122.
13. Uetz P., Giot L., Cagney G., Mansfield T.A., Judson R.S., Knight J.R., Lockshon D., Narayan V., Srinivasan M., Pochart P., Qureshi-Emili A., Li Y., Godwin B., Conover D., Kalbfleisch T., Vijayadamodar G., Yang M., Johnston M., Fields S., Rothberg J.M. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature. 403:2000;623-627.
14. Ito T., Tashiro K., Muta S., Ozawa R., Chiba T., Nishizawa M., Yamamoto K., Kuhara S., Sakaki Y. Toward a protein-protein interaction map of the budding yeast a comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins . Proc. Natl. Acad. Sci. USA. 97:2000;1143-1147.
15. Pandey A., Mann M. Proteomics to study genes and genomes. Nature. 405:2000;837-846.
16. Hoshino T., Wang J.X., Devetten M.P., Iwata N., Kajigaya S., Wise R.J., Liu J.M., Youssoufian H. Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression. Blood. 91:1998;4379-4386.
17. Hoatlin M.E., Zhi Y., Ball H., Silvey K., Melnick A., Stone S., Arai S., Hawe N., Owen G., Zelent A., Licht J.D. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood. 94:1999;3737-3747.
18. Otsuki T., Kajigaya S., Ozawa K., Liu J.M. SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein. Biochem. Biophys. Res. Commun. 265:1999;630-635.
19. Otsuki T., Furukawa Y., Ikeda K., Endo H., Yamashita T., Shinohara A., Iwamatsu A., Ozawa K., Liu J.M. Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex. Human Mol. Genet. 10:2001;2651-2660.
20. Futaki M., Igarashi T., Watanabe S., Kajigaya S., Tatsuguchi A., Wang J., Liu J.M. The FANCG Fanconi anemia protein interacts with CYP2E1 possible role in protection against oxidative DNA damage . Carcinogenesis. 23:2002;67-72.
21. Otsuki T., Young D.B., Sasaki D.T., Pando M.P., Li J., Manning A., Hoekstra M., Hoatlin M.E., Mercurio F., Liu J.M. Fanconi anemia protein complex is a novel target of the IKK signalsome. J. Cell. Biochem. 86:2002;613-623.
22. Huber P.A., Medhurst A.L., Youssoufian H., Mathew C.G. Investigation of Fanconi anemia protein interactions by yeast two-hybrid analysis. Biochem. Biophys. Res. Commun. 268:2000;73-77.
23. Medhurst A.L., Huber P.A., Waisfisz Q., de Winter J.P., Mathew C.G. Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway. Human Mol. Genet. 10:2001;423-429.
24. Reuter T., Herterich S., Bernhard O., Hoehn H., Gross H.J. Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system. Blood. 95:2000;719-720.
25. Brent R., Ptashne M. A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell. 43:1985;729-736.
26. Waisfisz Q., de Winter J.P., Kruyt F.A., de Groot J., van der Weel L., Dijkmans L.M., Zhi Y., Arwert F., Scheper R.J., Youssoufian H., Hoatlin M.E., Joenje H. A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA. Proc. Natl. Acad.Sci. USA. 96:1999;10320-10325.
27. Golemis E.A., Brent R. Fused protein domains inhibit DNA binding by LexA. Mol. Cell. Biol. 12:1992;3006-3014.
28. Pang Q., Keeble W., Christianson T.A., Faulkner G.R., Bagby G.C. FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity. EMBO J. 20:2001;4478-4489.
29. Zhong S., Salomoni P., Ronchetti S., Guo A., Ruggero D., Pandolfi P.P. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. 191:2000;631-640.
30. Hollenbach A.D., McPherson C.J., Mientjes E.J., Iyengar R., Grosveld G. Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. J. Cell Sci. 115:2002;3319-3330.
31. Gongora R., Stephan R.P., Zhang Z., Cooper M.D. An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons. Immunity. 14:2001;727-737.
32. Stochaj U., Rother K.L. Nucleocytoplasmic trafficking of proteins with or without Ran? BioEssays. 21:1999;579-589.
33. Moore J.D. The Ran-GTPase and cell-cycle control. BioEssays. 23:2001;77-85.
34. Dasso M. Running on Ran nuclear transport and the mitotic spindle . Cell. 104:2001;321-324.
35. Nakamura M., Masuda H., Horii J., Kuma K., Yokoyama N., Ohba T., Nishitani H., Miyata T., Tanaka M., Nishimoto T. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin. J. Cell Biol. 143:1998;1041-1052.
36. Kalab P., Pu R.T., Dasso M. The ran GTPase regulates mitotic spindle assembly. Curr. Biol. 9:1999;481-484.
37. Hetzer M., Bilbao-Cortes D., Walther T.C., Gruss O.J., Mattaj I.W. GTP hydrolysis by Ran is required for nuclear envelope assembly. Mol. Cell. 5:2000;1013-1024.
38. Kieran M., Blank V., Logeat F., Vandekerckhove J., Lottspeich F., Le Bail O., Urban M.B., Kourilsky P., Baeuerle P.A., Israel A. The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the reloncogene product. Cell. 62:1990;1007-1018.
39. Inoue J., Kerr L.D., Rashid D., Davis N., Bose H.R. Jr., Verma I.M. Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors role of ankyrin repeats in the inhibition of DNA binding activity . Proc. Natl. Acad. Sci. USA. 89:1992;4333-4337.
40. Gerondakis S., Morrice N., Richardson I.B., Wettenhall R., Fecondo J., Grumont R.J. The activity of a 70 kilodalton I kappa B molecule identical to the carboxyl terminus of the p105 NF-kappa B precursor is modulated by protein kinase A. Cell Growth Differ. 4:1993;617-627.
41. Pickart C.M. Ubiquitin enters the new millennium. Mol. Cell. 8:2001;499-504.
42. Zhong Q., Lazar C.S., Tronchere H., Sato T., Meerloo T., Yeo M., Songyang Z., Emr S.D., Gill G.N. Endosomal localization and function of sorting nexin 1. Proc. Natl. Acad. Sci. USA. 99:2002;6767-6772.
43. Dai M.S., Chevallier N., Stone S., Heinrich M.C., McConnell M., Reuter T., Broxmeyer H.E., Licht J.D., Lu L., Hoatlin M.E. The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific. J. Biol. Chem. 277:2002;26327-26334.
44. Garcia-Higuera I., Kuang Y., Denham J., D'Andrea A.D. The Fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex. Blood. 96:2000;3224-3230.
45. Kruyt F.A.E., Hoshino T., Liu J.M., Joseph P., Jaiswal A.K., Youssoufian H. Abnormal microsomal detoxification implicated in Fanconi anemia group C by interaction of the FAC protein with NADPH cytochrome P450 reductase. Blood. 92:1998;3050-3056.
46. Ruppitsch W., Meisslitzer C., Weirich-Schwaiger H., Klocker H., Scheidereit C., Schweiger M., Hirsch-Kauffmann M. The role of oxygen metabolism for the pathological phenotype of Fanconi anemia. Human Genet. 99:1997;710-719.
47. Ruppitsch W., Meisslitzer C., Hirsch-Kauffmann M., Schweiger M. Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane. FEBS Lett. 422:1998;99-102.
48. Fagerlie S., Lensch M.W., Pang Q., Bagby G.C. The Fanconi anemia group C gene product. Signaling functions in hematopoietic cells. Exp. Hematol. 29:2001;1371-1381.
49. Cumming R.C., Lightfoot J., Beard K., Youssoufian H., O'Brien P.J., Buchwald M. Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1. Nat. Med. 7:2001;814-820.
50. Kupfer G.M., Yamashita T., Naf D., Suliman A., Asano S., D'Andrea A.D. The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2. Blood. 90:1997;1047-1054.
51. Taniguchi T., Garcia-Higuera I., Xu B., Andreassen P.R., Gregory R.C., Kim S.T., Lane W.S., Kastan M.B., D'Andrea A.D. Convergence of the Fanconi anemia and ataxia telangiectasia signaling pathways. Cell. 109:2002;459-472.
52. Folias A., Matkovic M., Bruun D., Reid S., Hejna J., Grompe M., D'Andrea A., Moses R. BRCA1 interacts directly with the Fanconi anemia protein FANCA. Human Mol. Genet. 11:2002;2591-2597.
53. McMahon L.W., Sangerman J., Goodman S.R., Kumaresan K., Lambert M.W. Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links. Biochemistry. 40:2001;7025-7034.
54. Pang Q., Fagerlie S., Christianson T.A., Keeble W., Faulkner G., Diaz J., Rathbun R.K., Bagby G.C. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. Mol. Cell. Biol. 20:2000;4724-4735.
55. Ouchi T., Lee S.W., Ouchi M., Aaronson S.A., Horvath C.M. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. Proc. Natl. Acad. Sci. USA. 97:2000;5208-5213.
56. Otsuki T., Nagashima T., Komatsu N., Kirito K., Furukawa Y., Kobayashi Si S., Liu J.M., Ozawa K. Phosphorylation of Fanconi anemia protein, FANCA, is regulated by Akt kinase. Biochem. Biophys. Res. Commun. 291:2002;628-634.
57. McMahon L.W., Walsh C.E., Lambert M.W. Human alpha Spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex. J. Biol. Chem. 274:1999;32904-32908.