Multiple mutant clones in blood rarely coexist

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

Volumn 77, Issue 2, 2008, Pages

  Dingli, David ^a,b   Pacheco, Jorge M ^b,c   Traulsen, Arne ^b,d  

^a Mayo Clinic   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF LISBON   (Portugal)

^d MAX PLANCK INSTITUTE FOR EVOLUTIONARY BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; GENETIC ENGINEERING; MEDICAL PROBLEMS; RANDOM PROCESSES;

BLOOD CELLS; HEMATOPOIETIC DISORDERS; STOCHASTIC DYNAMICS;

BLOOD;

EID: 40849124050     PISSN: 15393755     EISSN: 15502376     Source Type: Journal    
DOI: 10.1103/PhysRevE.77.021915     Document Type: Article

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42. The conservation of the average number of cells Nk in each compartment k, reflected in the values of ε and ηk used, allow us to use a Moran birth-death process to study cell dynamics in downstream compartments.
43. If the mutated cells proliferate faster, the ratio Tj+ / Tj- is not affected. Thus, the probabilities of fixation do not change, only the time scale. On average, faster cell proliferation will lead to a faster differentiation (and extinction) of the mutant cells in the compartment in which the mutants arise.