Intracellular accumulation and mechanism of action of doxorubicin in a spatio-temporal tumor model

Journal of Theoretical Biology

Volumn 220, Issue 2, 2003, Pages 201-213

  Jackson, Trachette L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN;

MODELING; TUMOR;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL TRANSPORT; DRUG ACCUMULATION; DRUG MECHANISM; DRUG PENETRATION; DRUG TRANSPORT; PREDICTION; PRIORITY JOURNAL; SIMULATION; TUMOR CELL; TUMOR MODEL; TUMOR REGRESSION; TUMOR RESISTANCE;

EID: 0037219540     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.2003.3156     Document Type: Article

References (35)

1. Andre, N., Braguer, D., Brasseur, G., Goncalves, A., Lemesle-Meunier, D., Guise, S., Jordan, M. & Briand, C. (2000). Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells. Cancer Res. 60, 5349.
2. Andreoni, A., Colsanti, A., Kisslinger, A., Mastro-cinque, M., Riccio, P. & Roberit, G. (1994). Fluor-metric-determination of the kinetics of anthra-cyclines uptake by cells. J. Biochem. Biophys. Meth. 28, 53.
3. Bagshawe, K. & Begent, R. (1996). First clinical experience with ADEPT. Adv. Drug Delivery Rev. 22, 365.
4. Baxter, L. & Jain, R. (1989). Transport of fluid and macro-molecules in tumors I: Role of interstitial pressure and convection. Mircovasc. Res. 37, 77.
5. Baxter, L. & Jain, R. (1996). Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: Comparison with experimental data. British J. Cancer 73, 447.
6. Byrne, H. & Chaplain, M. (1995). Growth of non-necrotic tumors in the presence and absence of inhibitors. Math. Biosci. 130, 151.
7. Byrne, H. & Chaplain, M. (1996). Modeling the role of cell-cell adhesion in the growth and development of carcinomas. Math. Comput. Modeling 24, 1.
8. Byrne, H. & Chaplain, M. (1997). Free boundary value problems associated with the growth and development of multicellular spheroids. Eur. J. Appl. Math. 8, 639.
9. Curry, F., Mason, J. & Michel, C. (1976). Osmotic reflection of coefficients of capillary to low molecular weight hydrophilic solutes measures in single perfused capillaries of the frog mesentery. J. Physiol. London 261, 319.
10. Dalmark, M. & Storm, H. (1981). A fickian diffusion transport process with features of transport catalysis: Doxorubicin transport in human red blood cells. J. Gen Physiol. 78, 349.
11. Deen, W. (1987). Hindered transport of large molecules in liquid-filled pores. AIChE J. 33, 1409.
12. Degregorio, M., Lui, G., Macher, B. & Wilbur, J. (1984). Uptake, metabolism, and cytotoxicity of doxorubicin in human ewing's sarcoma and rhabdomyosarcoma cells. Cancer Chemo. Pharm. 12, 59.
13. Demant, E. & Friche, E. (1998). Kinetics of anthracycline accumulation in multidrug-resistant tumor cells: Relationship to drug lipophilicity and serum ablumin binding. Biochem. Pharm. 56, 1209.
14. Dordal, M., Ho, A., Jackson-Stone, M., Fu, Y., Goolsby, C. & Winter, J. (1995). Flow cytometric assessment of the cellular pharmacokinetics of fluorescent drugs. Cytometry 20, 307.
15. Dordal, M., Jackson-Stone, M., Ho, A., Winter, J. & Atkinson, A. (1994). Decreased intracellular compartmentalization of doxorubicin in cell lines expressing p-glycoprotein. J. Pharm. Exp. Ther. 271, 1286.
16. Dordal, M., Winter, J. & Atkinson, A. (1992). Kinetic analysis of p-glycoprotein-mediated doxorubicin efflux. J. Pharmacol. Exp. Ther. 263, 762.
17. Fulda, S., Sieverts, H., Friesen, C., Herr, I. & Debatin, K. (1997). The cd95 (apo-1/fas) system mediates drug-induced apoptosis in neuroblastoma cells. Cancer Res. 3823, 57.
18. Fulda, S., Strauss, G., Meyer, E. & Debatin, K. (2000). Functional cd95 ligand and cd95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic t cells. Blood 95, 301.
19. Gieseler, F., Biersack, H., Manderscheid, J. & Nussler, V. (1994). Cytotoxicity of anthracyclines - Correlation with cellular uptake, intracellular-distribution and dna-binding. Ann. Hematol. 69, S13.
20. Jackson, T. (2002). Vascular tumor growth and treatment: Consequences of polyclonality, competition, and dynamic vascular support. J. Math. Biol. 44, 201-206.
21. Jackson, T. & Byrne, H. (2000). A mathematical model to study the effects of drug resistance and vasculature on the response of solid tumors to chemotherapy. Math. Biosci. 164, 17.
22. Jackson, T., Lubkin, S. & Murray, J. (1999). Theoretical analysis of conjugate localization in two-step cancer chemotherapy. J. Math. Biol. 39, 353.
23. Jackson, T., Senter, P. & Murray, J. (2000). Development and validation of a mathematical model to describe anti-cancer prodrug activation by antibody-enzyme conjugates. J. Theor. Med. 2, 93.
24. Jain, R. (1987). Transport of macromolecules across tumor vasculature. Cancer Metastasis Rev. 6, 559.
25. Juranka, P., Zastawny, R. & Ling, V. (1989). P-glycoprotein: Multidrug-resistance and a super family of membrane-associated transport proteins. FASEB J. 3, 2583.
26. Kerr, D., Schreiber, G., Vrudhula, V., Svensson, H., Hellstrom, K. & Senter, P. (1995). Regressions and cures of melanoma xenografts following treatment with monoclonal antibody β-lactamase conjugates in combination with anti-cancer prodrugs. Cancer Res. 55, 3558.
27. Nugent, L. & Jain, R. (1984). Extravascular diffusion in normal and neoplastic tissues. Cancer Res. 44, 238.
28. Paul, C., Peterson, C., Gahrton, G. & Lockner, D. (1979). Uptake of free and DNA-bound daunorubicin and doxorubicin into human leukemic cells. Cancer Chemo. Pharm. 2, 49.
29. Shain, K., Landowski, T., Buyuksal, I., Cantor, A. & Dalton, W. (2000). Clonal variability in cd95 expression is the major determinant in fas-mediated, but not chemotherapy-mediated apoptosis in the rpmi 8226 multiple myeloma cell line. Leukemia 14, 830.
30. Siemers, N., Kerr, D., Yarnold, S., Stebbins, M., Vrudgyka, V., Hellstrom, I., Hellstrom, K. & Senter, P. (1997). L49-sfv-β-lactamase, a single chain anti-p97 antibody fusion protein. Bioconjugate Chem. 8, 510.
31. Solovyan, V., Bezvenyuk, Z., Huotari, V., Tapiola, T., Suuronen, T. & Salminen, A. (1998). Distinct mode of apoptosis induced by genotoxic agent etoposide and serum withdrawal in neuroblastoma cells. Molec. Brain Res. 61, 43.
32. Svensson, H., Vrudhula, V., Emswiler, J., Mac-Master, J. & Cosand, W. (1995). In vitro and in vivo activities of doxorubicin prodrug in combination with monoclonal antibody filactamase conjugates. Cancer Res. 55, 2557.
33. Thornberry, N. & Lazebuik, Y. (1998). Caspases: Enemies within. Science 281, 1312.
34. Trail, P., Willner, D., Knipe, J., Henderson, A., Lasch, S. et al. (1997). Effect of liner variation on the stability, potency, and efficacy of carcinoma-reactive br64-doxorubicin immunoconjugates. Cancer Res. 57, 100.
35. Young, R., Ozols, R. & Meyers, C. (1981). The anthracycline antineoplastic drugs. New Engl. J. Med. 305, 139.