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Volumn 105, Issue 47, 2008, Pages 18496-18500

Neutral evolution in paroxysmal nocturnal hemoglobinuria

Author keywords

Hematopoiesis; Mathematical modeling; Mutation; Stem cells; Stochastic dynamics

Indexed keywords

ADULT; ARTICLE; BONE MARROW; CLINICAL ARTICLE; HUMAN; INCIDENCE; MATHEMATICAL MODEL; MOLECULAR EVOLUTION; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PRIORITY JOURNAL; SIMULATION; STATISTICS; STEM CELL;

EID: 57449083619     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802749105     Document Type: Article
Times cited : (45)

References (56)
  • 1
    • 28444483571 scopus 로고    scopus 로고
    • Diagnosis and management of paroxysmal nocturnal hemoglobinuria
    • Parker C, et al. (2005) Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood 106:3699-3709.
    • (2005) Blood , vol.106 , pp. 3699-3709
    • Parker, C.1
  • 2
    • 0030932540 scopus 로고    scopus 로고
    • Somatic mutations in paroxysmal nocturnal hemoglobinuria: A blessing in disguise?
    • Luzzatto L, Bessler M, Rotoli B (1997) Somatic mutations in paroxysmal nocturnal hemoglobinuria: A blessing in disguise? Cell 88:1-4.
    • (1997) Cell , vol.88 , pp. 1-4
    • Luzzatto, L.1    Bessler, M.2    Rotoli, B.3
  • 3
    • 0027198876 scopus 로고
    • Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria
    • Hillmen P, Bessler M, Mason PJ, Watkins WM, Luzzatto L (1993) Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria. Proc Natl Acad Sci USA 90:5272-5276.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5272-5276
    • Hillmen, P.1    Bessler, M.2    Mason, P.J.3    Watkins, W.M.4    Luzzatto, L.5
  • 4
    • 0028057618 scopus 로고
    • Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria
    • Miyata T, et al. (1994) Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med 330:249-255.
    • (1994) N Engl J Med , vol.330 , pp. 249-255
    • Miyata, T.1
  • 5
    • 0024325872 scopus 로고
    • Paroxysmal nocturnal hemoglobinuria
    • Rotoli B, Luzzatto L (1989) Paroxysmal nocturnal hemoglobinuria. Semin Hematol 26:201-207.
    • (1989) Semin Hematol , vol.26 , pp. 201-207
    • Rotoli, B.1    Luzzatto, L.2
  • 6
    • 0034882347 scopus 로고    scopus 로고
    • The cellular pathogenesis of paroxysmal nocturnal haemoglobinuria
    • Karadimitris A, Luzzatto L (2001) The cellular pathogenesis of paroxysmal nocturnal haemoglobinuria. Leukemia 15:1148-1152.
    • (2001) Leukemia , vol.15 , pp. 1148-1152
    • Karadimitris, A.1    Luzzatto, L.2
  • 7
    • 33845494914 scopus 로고    scopus 로고
    • Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH)
    • Inoue N, et al. (2006) Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood 108:4232-4236.
    • (2006) Blood , vol.108 , pp. 4232-4236
    • Inoue, N.1
  • 8
    • 0028231054 scopus 로고
    • Routes to repopulation - a unification of the stochastic model and separation of stem-cell subpopulations
    • Gordon MY, Blackett NM (1994) Routes to repopulation - a unification of the stochastic model and separation of stem-cell subpopulations. Leukemia 8:1068-1073.
    • (1994) Leukemia , vol.8 , pp. 1068-1073
    • Gordon, M.Y.1    Blackett, N.M.2
  • 9
    • 54949134429 scopus 로고    scopus 로고
    • Allometric scaling of the active hematopoietic stem cell pool across mammals
    • Dingli D, Pacheco JM (2006) Allometric scaling of the active hematopoietic stem cell pool across mammals. PLoS ONE 1:e2.
    • (2006) PLoS ONE , vol.1
    • Dingli, D.1    Pacheco, J.M.2
  • 10
    • 34548779716 scopus 로고    scopus 로고
    • Ontogenic growth of the haemopoietic stem cell pool in humans
    • Dingli D, Pacheco JM (2007) Ontogenic growth of the haemopoietic stem cell pool in humans. Proc Biol Sci 274:2497-2501.
    • (2007) Proc Biol Sci , vol.274 , pp. 2497-2501
    • Dingli, D.1    Pacheco, J.M.2
  • 11
    • 33847774266 scopus 로고    scopus 로고
    • Stochastic dynamics of hematopoietic tumor stem cells
    • Dingli D, Traulsen A, Pacheco JM (2007) Stochastic dynamics of hematopoietic tumor stem cells. Cell Cycle 6:461-466.
    • (2007) Cell Cycle , vol.6 , pp. 461-466
    • Dingli, D.1    Traulsen, A.2    Pacheco, J.M.3
  • 12
    • 0345643319 scopus 로고    scopus 로고
    • Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
    • Rufer N, et al. (1999) Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med 190:157-167.
    • (1999) J Exp Med , vol.190 , pp. 157-167
    • Rufer, N.1
  • 13
    • 0028077099 scopus 로고
    • Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age
    • Vaziri H, et al. (1994) Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age. Proc Natl Acad Sci USA 91:9857-9860.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9857-9860
    • Vaziri, H.1
  • 14
    • 7944237809 scopus 로고    scopus 로고
    • Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths
    • Shepherd BE, Guttorp P, Lansdorp PM, Abkowitz JL (2004) Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths. Exp Hematol 32:1040-1050.
    • (2004) Exp Hematol , vol.32 , pp. 1040-1050
    • Shepherd, B.E.1    Guttorp, P.2    Lansdorp, P.M.3    Abkowitz, J.L.4
  • 15
    • 0030928170 scopus 로고    scopus 로고
    • Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age
    • Gale RE, Fielding AK, Harrison CN, Linch DC (1997) Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age. Br J Haematol 98:512-519.
    • (1997) Br J Haematol , vol.98 , pp. 512-519
    • Gale, R.E.1    Fielding, A.K.2    Harrison, C.N.3    Linch, D.C.4
  • 16
    • 33750126450 scopus 로고    scopus 로고
    • Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment
    • McKenzie JL, Gan OI, Doedens M, Wang JC, Dick JE (2006) Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment. Nat Immunol 7:1225-1233.
    • (2006) Nat Immunol , vol.7 , pp. 1225-1233
    • McKenzie, J.L.1    Gan, O.I.2    Doedens, M.3    Wang, J.C.4    Dick, J.E.5
  • 17
    • 0025221852 scopus 로고
    • Evidence for the maintenance of hematopoiesis in a large animal by the sequential activation of stem-cell clones
    • Abkowitz JL, et al. (1990) Evidence for the maintenance of hematopoiesis in a large animal by the sequential activation of stem-cell clones. Proc Natl Acad Sci USA 87:9062-9066.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9062-9066
    • Abkowitz, J.L.1
  • 18
    • 0022408052 scopus 로고
    • Use of an X-linked human neutrophil marker to estimate timing of lyonization and size of the dividing stem cell pool
    • Buescher ES, Alling DW, Gallin JI (1985) Use of an X-linked human neutrophil marker to estimate timing of lyonization and size of the dividing stem cell pool. J Clin Invest 76:1581-1584.
    • (1985) J Clin Invest , vol.76 , pp. 1581-1584
    • Buescher, E.S.1    Alling, D.W.2    Gallin, J.I.3
  • 21
    • 33646527709 scopus 로고    scopus 로고
    • The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH)
    • Araten DJ, Luzzatto L (2006) The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood 108:734-736.
    • (2006) Blood , vol.108 , pp. 734-736
    • Araten, D.J.1    Luzzatto, L.2
  • 22
    • 0024264749 scopus 로고
    • Polyclonal reconstitution of human marrow after allogeneic bone marrow transplantation
    • Nash R, Storb R, Neiman P (1988) Polyclonal reconstitution of human marrow after allogeneic bone marrow transplantation. Blood 72:2031-2037.
    • (1988) Blood , vol.72 , pp. 2031-2037
    • Nash, R.1    Storb, R.2    Neiman, P.3
  • 23
    • 24944581966 scopus 로고    scopus 로고
    • A quantitative measurement of the human somatic mutation rate
    • Araten DJ, et al. (2005) A quantitative measurement of the human somatic mutation rate. Cancer Res 65:8111-8117.
    • (2005) Cancer Res , vol.65 , pp. 8111-8117
    • Araten, D.J.1
  • 24
    • 0033609114 scopus 로고    scopus 로고
    • Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals
    • Araten DJ, Nafa K, Pakdeesuwan K, Luzzatto L (1999) Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals. Proc Natl Acad Sci USA 96:5209-5214.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5209-5214
    • Araten, D.J.1    Nafa, K.2    Pakdeesuwan, K.3    Luzzatto, L.4
  • 25
    • 0036788712 scopus 로고    scopus 로고
    • Evidence that the number of hematopoietic stem cells per animal is conserved in mammals
    • Abkowitz JL, Catlin SN, McCallie MT, Guttorp P (2002) Evidence that the number of hematopoietic stem cells per animal is conserved in mammals. Blood 100:2665-2667.
    • (2002) Blood , vol.100 , pp. 2665-2667
    • Abkowitz, J.L.1    Catlin, S.N.2    McCallie, M.T.3    Guttorp, P.4
  • 26
    • 21744462100 scopus 로고    scopus 로고
    • Dynamics of chronic myeloid leukaemia
    • Michor F, et al. (2005) Dynamics of chronic myeloid leukaemia. Nature 435:1267-1270.
    • (2005) Nature , vol.435 , pp. 1267-1270
    • Michor, F.1
  • 27
    • 55849111535 scopus 로고    scopus 로고
    • Compartmental architecture and dynamics of hematopoiesis
    • Dingli D, Traulsen A, Pacheco JM (2007) Compartmental architecture and dynamics of hematopoiesis. PLoS ONE 2:e345.
    • (2007) PLoS ONE , vol.2
    • Dingli, D.1    Traulsen, A.2    Pacheco, J.M.3
  • 28
    • 18544381754 scopus 로고    scopus 로고
    • PIG-A mutations in normal hematopoiesis
    • Hu R, et al. (2005) PIG-A mutations in normal hematopoiesis. Blood 105:3848-3854.
    • (2005) Blood , vol.105 , pp. 3848-3854
    • Hu, R.1
  • 30
    • 2442532784 scopus 로고    scopus 로고
    • Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan
    • Nishimura J, et al. (2004) Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine (Baltimore) 83:193-207.
    • (2004) Medicine (Baltimore) , vol.83 , pp. 193-207
    • Nishimura, J.1
  • 31
    • 0028110863 scopus 로고
    • Mutations in the PIG-A gene causing partial deficiency of GPI-linked surface proteins (PNH II) in patients with paroxysmal nocturnal haemoglobinuria
    • Bessler M, Mason PJ, Hillmen P, Luzzatto L (1994) Mutations in the PIG-A gene causing partial deficiency of GPI-linked surface proteins (PNH II) in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol 87:863-866.
    • (1994) Br J Haematol , vol.87 , pp. 863-866
    • Bessler, M.1    Mason, P.J.2    Hillmen, P.3    Luzzatto, L.4
  • 32
    • 0028299834 scopus 로고
    • Somatic mutations and cellular selection in paroxysmal nocturnal haemoglobinuria
    • Bessler M, Mason P, Hillmen P, Luzzatto L (1994) Somatic mutations and cellular selection in paroxysmal nocturnal haemoglobinuria. Lancet 343:951-953.
    • (1994) Lancet , vol.343 , pp. 951-953
    • Bessler, M.1    Mason, P.2    Hillmen, P.3    Luzzatto, L.4
  • 33
    • 0037769826 scopus 로고    scopus 로고
    • The spectrum of PIG-A gene mutations in aplastic anemia/paroxysmal nocturnal hemoglobinuria (AA/PNH): A high incidence of multiple mutations and evidence of a mutational hot spot
    • Mortazavi Y, et al. (2003) The spectrum of PIG-A gene mutations in aplastic anemia/paroxysmal nocturnal hemoglobinuria (AA/PNH): A high incidence of multiple mutations and evidence of a mutational hot spot. Blood 101:2833-2841.
    • (2003) Blood , vol.101 , pp. 2833-2841
    • Mortazavi, Y.1
  • 34
    • 37349071491 scopus 로고    scopus 로고
    • On the origin of multiple mutant clones in paroxysmal nocturnal hemoglobinuria
    • Traulsen A, Pacheco JM, Dingli D (2007) On the origin of multiple mutant clones in paroxysmal nocturnal hemoglobinuria. Stem Cells 25:3081-3084.
    • (2007) Stem Cells , vol.25 , pp. 3081-3084
    • Traulsen, A.1    Pacheco, J.M.2    Dingli, D.3
  • 35
    • 0035053036 scopus 로고    scopus 로고
    • The distribution of PIG-A gene abnormalities in paroxysmal nocturnal hemoglobinuria granulocytes and cultured erythroblasts
    • Noji H, et al. (2001) The distribution of PIG-A gene abnormalities in paroxysmal nocturnal hemoglobinuria granulocytes and cultured erythroblasts. Exp Hematol 29:391-400.
    • (2001) Exp Hematol , vol.29 , pp. 391-400
    • Noji, H.1
  • 36
    • 0037111663 scopus 로고    scopus 로고
    • Phenotypes and phosphatidylinositol glycan-class A gene abnormalities during cell differentiation and maturation from precursor cells to mature granulocytes in patients with paroxysmal nocturnal hemoglobinuria
    • Kai T, et al. (2002) Phenotypes and phosphatidylinositol glycan-class A gene abnormalities during cell differentiation and maturation from precursor cells to mature granulocytes in patients with paroxysmal nocturnal hemoglobinuria. Blood 100:3812-3818.
    • (2002) Blood , vol.100 , pp. 3812-3818
    • Kai, T.1
  • 37
    • 4243107303 scopus 로고    scopus 로고
    • Clinical and molecular aspects of 23 patients affected by paroxysmal nocturnal hemoglobinuria
    • Boschetti C, et al. (2004) Clinical and molecular aspects of 23 patients affected by paroxysmal nocturnal hemoglobinuria. Am J Hematol 77:36-44.
    • (2004) Am J Hematol , vol.77 , pp. 36-44
    • Boschetti, C.1
  • 38
    • 0019990451 scopus 로고
    • Decreased number of circulating BFU-Es in paroxysmal nocturnal hemoglobinuria
    • Rotoli B, Robledo R, Luzzatto L (1982) Decreased number of circulating BFU-Es in paroxysmal nocturnal hemoglobinuria. Blood 60:157-159.
    • (1982) Blood , vol.60 , pp. 157-159
    • Rotoli, B.1    Robledo, R.2    Luzzatto, L.3
  • 39
    • 0027310539 scopus 로고
    • Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria
    • Takeda J, et al. (1993) Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell 73:703-711.
    • (1993) Cell , vol.73 , pp. 703-711
    • Takeda, J.1
  • 40
    • 0035801698 scopus 로고    scopus 로고
    • FES-Cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrow
    • Keller P, et al. (2001) FES-Cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrow. J Exp Med 194:581-589.
    • (2001) J Exp Med , vol.194 , pp. 581-589
    • Keller, P.1
  • 41
    • 0036849382 scopus 로고    scopus 로고
    • Dynamics of hematopoiesis in paroxysmal nocturnal hemoglobinuria (PNH): No evidence for intrinsic growth advantage of PNH clones
    • Araten DJ, et al. (2002) Dynamics of hematopoiesis in paroxysmal nocturnal hemoglobinuria (PNH): No evidence for intrinsic growth advantage of PNH clones. Leukemia 16:2243-2248.
    • (2002) Leukemia , vol.16 , pp. 2243-2248
    • Araten, D.J.1
  • 42
    • 0033105696 scopus 로고    scopus 로고
    • Resistance of paroxysmal nocturnal hemoglobinuria cells to the glycosylphosphatidylinositol-binding toxin aerolysin
    • Brodsky RA, et al. (1999) Resistance of paroxysmal nocturnal hemoglobinuria cells to the glycosylphosphatidylinositol-binding toxin aerolysin. Blood 93:1749-1756.
    • (1999) Blood , vol.93 , pp. 1749-1756
    • Brodsky, R.A.1
  • 43
    • 0030822192 scopus 로고    scopus 로고
    • Apoptosis resistance of blood cells from patients with paroxysmal nocturnal hemoglobinuria, aplastic anemia, and myelodysplastic syndrome
    • Horikawa K, et al. (1997) Apoptosis resistance of blood cells from patients with paroxysmal nocturnal hemoglobinuria, aplastic anemia, and myelodysplastic syndrome. Blood 90:2716-2722.
    • (1997) Blood , vol.90 , pp. 2716-2722
    • Horikawa, K.1
  • 45
    • 57449117278 scopus 로고    scopus 로고
    • The investigation of HMGA2 dysregulation and promoter mutations in PIG-M in the molecular pathogenesis of paroxysmal nocturnal haemoglobinuria (PNH)
    • Kelly RJ, Tooze RM, Doogy GM, Richards SJ, Hillmen P (2007) The investigation of HMGA2 dysregulation and promoter mutations in PIG-M in the molecular pathogenesis of paroxysmal nocturnal haemoglobinuria (PNH). Blood 110:3671.
    • (2007) Blood , vol.110 , pp. 3671
    • Kelly, R.J.1    Tooze, R.M.2    Doogy, G.M.3    Richards, S.J.4    Hillmen, P.5
  • 46
    • 0015457605 scopus 로고
    • Paroxysmal nocturnal haemoglobinuria: Clinical manifestations, haematology, and nature of the disease
    • Dacie JV, Lewis SM (1972) Paroxysmal nocturnal haemoglobinuria: Clinical manifestations, haematology, and nature of the disease. Ser Haematol 5:3-23.
    • (1972) Ser Haematol , vol.5 , pp. 3-23
    • Dacie, J.V.1    Lewis, S.M.2
  • 47
    • 0037006957 scopus 로고    scopus 로고
    • Acquired aplastic anemia
    • Young NS (2002) Acquired aplastic anemia. Ann Intern Med 136:534-546.
    • (2002) Ann Intern Med , vol.136 , pp. 534-546
    • Young, N.S.1
  • 48
    • 0034307521 scopus 로고    scopus 로고
    • Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria
    • Karadimitris A, et al. (2000) Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria. Blood 96:2613-2620.
    • (2000) Blood , vol.96 , pp. 2613-2620
    • Karadimitris, A.1
  • 49
    • 0035673393 scopus 로고    scopus 로고
    • Association of clonal T-cell large granular lymphocyte disease and paroxysmal nocturnal haemoglobinuria (PNH): Further evidence for a pathogenetic link between T cells, aplastic anaemia, and PNH
    • Karadimitris A, et al. (2001) Association of clonal T-cell large granular lymphocyte disease and paroxysmal nocturnal haemoglobinuria (PNH): Further evidence for a pathogenetic link between T cells, aplastic anaemia, and PNH. Br J Haematol 115:1010-1014.
    • (2001) Br J Haematol , vol.115 , pp. 1010-1014
    • Karadimitris, A.1
  • 50
    • 0036660175 scopus 로고    scopus 로고
    • Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry
    • Risitano AM, et al. (2002) Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry. Blood 100:178-183.
    • (2002) Blood , vol.100 , pp. 178-183
    • Risitano, A.M.1
  • 51
    • 13544257461 scopus 로고    scopus 로고
    • Large granular lymphocyte (LGL)-like clonal expansions in paroxysmal nocturnal hemoglobinuria (PNH) patients
    • Risitano AM, et al. (2005) Large granular lymphocyte (LGL)-like clonal expansions in paroxysmal nocturnal hemoglobinuria (PNH) patients. Leukemia 19:217-222.
    • (2005) Leukemia , vol.19 , pp. 217-222
    • Risitano, A.M.1
  • 52
    • 27144506207 scopus 로고    scopus 로고
    • Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors
    • Poggi A, et al. (2005) Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors. Blood 106:2399-2408.
    • (2005) Blood , vol.106 , pp. 2399-2408
    • Poggi, A.1
  • 53
    • 34249721475 scopus 로고    scopus 로고
    • Highly homologous T-cell receptor beta sequences support a common target for autoreactive T cells in most patients with paroxysmal nocturnal hemoglobinuria
    • Gargiulo L, et al. (2007) Highly homologous T-cell receptor beta sequences support a common target for autoreactive T cells in most patients with paroxysmal nocturnal hemoglobinuria. Blood 109:5036-5042.
    • (2007) Blood , vol.109 , pp. 5036-5042
    • Gargiulo, L.1
  • 54
    • 0031032545 scopus 로고    scopus 로고
    • Clinical characteristics predict response to antithymocyte globulin in paroxysmal nocturnal haemoglobinuria
    • Paquette RL, et al. (1997) Clinical characteristics predict response to antithymocyte globulin in paroxysmal nocturnal haemoglobinuria. Br J Haematol 96:92-97.
    • (1997) Br J Haematol , vol.96 , pp. 92-97
    • Paquette, R.L.1
  • 55
    • 0030065744 scopus 로고    scopus 로고
    • Evidence that hematopoiesis may be a stochastic process in vivo
    • Abkowitz JL, Catlin SN, Guttorp P (1996) Evidence that hematopoiesis may be a stochastic process in vivo. Nat Med 2:190-197.
    • (1996) Nat Med , vol.2 , pp. 190-197
    • Abkowitz, J.L.1    Catlin, S.N.2    Guttorp, P.3
  • 56
    • 54049098831 scopus 로고    scopus 로고
    • Paroxysmal nocturnal hemoglobinuria: Natural history of disease subcategories
    • Peffault de Latour R, et al. (2008) Paroxysmal nocturnal hemoglobinuria: Natural history of disease subcategories. Blood 112:3099-3106.
    • (2008) Blood , vol.112 , pp. 3099-3106
    • Peffault de Latour, R.1


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