메뉴 건너뛰기




Volumn 32, Issue 11, 2010, Pages 1003-1008

Somatic mutations and the hierarchy of hematopoiesis

Author keywords

Clonal evolution; Hematopoietic stem cells; Mutations; Progenitor cells; Stochastic dynamics

Indexed keywords

BCR ABL PROTEIN; JANUS KINASE 2;

EID: 77958188488     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201000025     Document Type: Article
Times cited : (24)

References (54)
  • 2
    • 24944581966 scopus 로고    scopus 로고
    • A quantitative measurement of the human somatic mutation rate
    • Araten DJ, Golde DW, Zhang RH, et al., 2005., A quantitative measurement of the human somatic mutation rate., Cancer Res, 65: 8111-17.
    • (2005) Cancer Res , vol.65 , pp. 8111-8117
    • Araten, D.J.1    Golde, D.W.2    Zhang, R.H.3
  • 3
    • 77952542840 scopus 로고    scopus 로고
    • The use of PIG-A as a sentinel gene for the study of the somatic mutation rate and of mutagenic agents in vivo
    • Peruzzi B, Araten DJ, Notaro R, Luzzatto L., 2010., The use of PIG-A as a sentinel gene for the study of the somatic mutation rate and of mutagenic agents in vivo, Mutat Res, 705: 3-10.
    • (2010) Mutat Res , vol.705 , pp. 3-10
    • Peruzzi, B.1    Araten, D.J.2    Notaro, R.3    Luzzatto, L.4
  • 4
    • 0016692602 scopus 로고
    • Mutation selection and the natural history of cancer
    • Cairns J., 1975., Mutation selection and the natural history of cancer., Nature, 255: 197-200.
    • (1975) Nature , vol.255 , pp. 197-200
    • Cairns, J.1
  • 5
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA., 2000., The hallmarks of cancer., Cell, 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW., 2004., Cancer genes and the pathways they control., Nat Med, 10: 789-99.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 7
    • 45549085055 scopus 로고    scopus 로고
    • Genetic instability is not a requirement for tumor development
    • discussion 3560-3551.
    • Bodmer W, Bielas JH, Beckman RA., 2008., Genetic instability is not a requirement for tumor development., Cancer Res, 68: 3558-60 discussion 3560-3551.
    • (2008) Cancer Res , vol.68 , pp. 3558-3560
    • Bodmer, W.1    Bielas, J.H.2    Beckman, R.A.3
  • 8
    • 0033011006 scopus 로고    scopus 로고
    • Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog
    • Tomlinson I, Bodmer W., 1999., Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog., Nat Med, 5: 11-12.
    • (1999) Nat Med , vol.5 , pp. 11-12
    • Tomlinson, I.1    Bodmer, W.2
  • 9
    • 0032211172 scopus 로고    scopus 로고
    • The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease
    • Bose S, Deininger M, Gora-Tybor J, et al., 1998., The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease., Blood, 92: 3362-67.
    • (1998) Blood , vol.92 , pp. 3362-3367
    • Bose, S.1    Deininger, M.2    Gora-Tybor, J.3
  • 10
    • 0033609114 scopus 로고    scopus 로고
    • Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals
    • Araten DJ, Nafa K, Pakdeesuwan K, Luzzatto L., 1999., Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals., Proc Natl Acad Sci USA, 96: 5209-14.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5209-5214
    • Araten, D.J.1    Nafa, K.2    Pakdeesuwan, K.3    Luzzatto, L.4
  • 11
    • 33744999628 scopus 로고    scopus 로고
    • Classification of chronic myeloid disorders: from Dameshek towards a semi-molecular system
    • Tefferi A, Gilliland G., 2006., Classification of chronic myeloid disorders: from Dameshek towards a semi-molecular system., Best Pract Res Clin Haematol, 19: 365-85.
    • (2006) Best Pract Res Clin Haematol , vol.19 , pp. 365-385
    • Tefferi, A.1    Gilliland, G.2
  • 12
    • 33646470398 scopus 로고    scopus 로고
    • A Unique Activating Mutation in JAK2 (V617F) Is at the Origin of Polycythemia Vera and Allows a New Classification of Myeloproliferative Diseases. Hematology Am Soc Hematol Educ Program:
    • Vainchenker W, Constantinescu SN., 2005. A Unique Activating Mutation in JAK2 (V617F) Is at the Origin of Polycythemia Vera and Allows a New Classification of Myeloproliferative Diseases. Hematology Am Soc Hematol Educ Program: 195-200.
    • (2005) , pp. 195-200
    • Vainchenker, W.1    Constantinescu, S.N.2
  • 13
    • 34548240698 scopus 로고    scopus 로고
    • Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
    • Levine RL, Pardanani A, Tefferi A, Gilliland DG., 2007., Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders., Nat Rev Cancer, 7: 673-83.
    • (2007) Nat Rev Cancer , vol.7 , pp. 673-683
    • Levine, R.L.1    Pardanani, A.2    Tefferi, A.3    Gilliland, D.G.4
  • 14
    • 70449217100 scopus 로고
    • Quantitative measurement of the erythrocytic and granulocytic cells of the marrow and blood
    • Donohue DM, Reiff RH, Hanson ML, et al., 1958., Quantitative measurement of the erythrocytic and granulocytic cells of the marrow and blood., J Clin Invest, 37: 1571-76.
    • (1958) J Clin Invest , vol.37 , pp. 1571-1576
    • Donohue, D.M.1    Reiff, R.H.2    Hanson, M.L.3
  • 17
    • 0010478892 scopus 로고
    • Proliferation of hemopoietic colony-forming cells transplanted into irradiated mice
    • McCulloch EA, Till JE., 1964., Proliferation of hemopoietic colony-forming cells transplanted into irradiated mice., Radiat Res, 22: 383-97.
    • (1964) Radiat Res , vol.22 , pp. 383-397
    • McCulloch, E.A.1    Till, J.E.2
  • 18
    • 0022408052 scopus 로고
    • Use of an X-linked human neutrophil marker to estimate timing of lyonization and size of the dividing stem cell pool
    • Buescher ES, Alling DW, Gallin JI., 1985., Use of an X-linked human neutrophil marker to estimate timing of lyonization and size of the dividing stem cell pool., J Clin Invest, 76: 1581-84.
    • (1985) J Clin Invest , vol.76 , pp. 1581-1584
    • Buescher, E.S.1    Alling, D.W.2    Gallin, J.I.3
  • 19
    • 54949134429 scopus 로고    scopus 로고
    • Allometric scaling of the active hematopoietic stem cell pool across mammals
    • Dingli D, Pacheco JM., 2006., Allometric scaling of the active hematopoietic stem cell pool across mammals., PLoS ONE, 1: e2.
    • (2006) PLoS ONE , vol.1
    • Dingli, D.1    Pacheco, J.M.2
  • 20
    • 0345643319 scopus 로고    scopus 로고
    • Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
    • Rufer N, Brummendorf TH, Kolvraa S, et al., 1999., Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood., J Exp Med, 190: 157-67.
    • (1999) J Exp Med , vol.190 , pp. 157-167
    • Rufer, N.1    Brummendorf, T.H.2    Kolvraa, S.3
  • 21
    • 55849111535 scopus 로고    scopus 로고
    • Compartmental architecture and dynamics of hematopoiesis
    • Dingli D, Traulsen A, Pacheco JM., 2007., Compartmental architecture and dynamics of hematopoiesis., PLoS ONE, 2: e345.
    • (2007) PLoS ONE , vol.2
    • Dingli, D.1    Traulsen, A.2    Pacheco, J.M.3
  • 22
    • 0028231054 scopus 로고
    • Routes to repopulation-a unification of the stochastic model and separation of stem-cell subpopulations
    • discussion 1072-63.
    • Gordon MY, Blackett NM., 1994., Routes to repopulation-a unification of the stochastic model and separation of stem-cell subpopulations., Leukemia, 8: 1068-72 discussion 1072-63.
    • (1994) Leukemia , vol.8 , pp. 1068-1072
    • Gordon, M.Y.1    Blackett, N.M.2
  • 23
    • 0030065744 scopus 로고    scopus 로고
    • Evidence that hematopoiesis may be a stochastic process in vivo
    • Abkowitz JL, Catlin SN, Guttorp P., 1996., Evidence that hematopoiesis may be a stochastic process in vivo, Nat Med, 2: 190-97.
    • (1996) Nat Med , vol.2 , pp. 190-197
    • Abkowitz, J.L.1    Catlin, S.N.2    Guttorp, P.3
  • 24
    • 37349071491 scopus 로고    scopus 로고
    • On the origin of multiple mutant clones in paroxysmal nocturnal hemoglobinuria
    • Traulsen A, Pacheco JM, Dingli D., 2007., On the origin of multiple mutant clones in paroxysmal nocturnal hemoglobinuria., Stem Cells, 25: 3081-84.
    • (2007) Stem Cells , vol.25 , pp. 3081-3084
    • Traulsen, A.1    Pacheco, J.M.2    Dingli, D.3
  • 26
    • 57449083619 scopus 로고    scopus 로고
    • Neutral evolution in paroxysmal nocturnal hemoglobinuria
    • Dingli D, Luzzatto L, Pacheco JM., 2008., Neutral evolution in paroxysmal nocturnal hemoglobinuria., Proc Natl Acad Sci USA, 105: 18496-500.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18496-18500
    • Dingli, D.1    Luzzatto, L.2    Pacheco, J.M.3
  • 27
    • 67649954581 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: origin, development, response to therapy, and relapse
    • Dingli D, Traulsen A, Pacheco JM., 2008., Chronic myeloid leukemia: origin, development, response to therapy, and relapse., Clin Leuk, 2: 133-39.
    • (2008) Clin Leuk , vol.2 , pp. 133-139
    • Dingli, D.1    Traulsen, A.2    Pacheco, J.M.3
  • 28
    • 77953201896 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor therapy can cure chronic myeloid leukemia without hitting leukemic stem cells
    • Lenaerts T, Pacheco JM, Traulsen A, Dingli D., 2009., Tyrosine kinase inhibitor therapy can cure chronic myeloid leukemia without hitting leukemic stem cells., Haematologica, 95: 900-7.
    • (2009) Haematologica , vol.95 , pp. 900-907
    • Lenaerts, T.1    Pacheco, J.M.2    Traulsen, A.3    Dingli, D.4
  • 29
    • 33847774266 scopus 로고    scopus 로고
    • Stochastic dynamics of hematopoietic tumor stem cells
    • Dingli D, Traulsen A, Pacheco JM., 2007., Stochastic dynamics of hematopoietic tumor stem cells., Cell Cycle, 6: 461-66.
    • (2007) Cell Cycle , vol.6 , pp. 461-466
    • Dingli, D.1    Traulsen, A.2    Pacheco, J.M.3
  • 30
    • 0036739742 scopus 로고    scopus 로고
    • Human haematopoiesis in steady state and following intense perturbations
    • Shochat E, Stemmer SM, Segel L., 2002., Human haematopoiesis in steady state and following intense perturbations., Bull Math Biol, 64: 861-86.
    • (2002) Bull Math Biol , vol.64 , pp. 861-886
    • Shochat, E.1    Stemmer, S.M.2    Segel, L.3
  • 31
    • 34548843616 scopus 로고    scopus 로고
    • Examples of mathematical modeling: tales from the crypt
    • Johnston MD, Edwards CM, Bodmer WF, et al., 2007., Examples of mathematical modeling: tales from the crypt., Cell Cycle, 6: 2106-12.
    • (2007) Cell Cycle , vol.6 , pp. 2106-2112
    • Johnston, M.D.1    Edwards, C.M.2    Bodmer, W.F.3
  • 32
    • 34247267072 scopus 로고    scopus 로고
    • Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer
    • Johnston MD, Edwards CM, Bodmer WF, et al., 2007., Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer., Proc Natl Acad Sci USA, 104: 4008-13.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4008-4013
    • Johnston, M.D.1    Edwards, C.M.2    Bodmer, W.F.3
  • 34
    • 0017234980 scopus 로고
    • Nonrandom distribution of chromosome breaks in cultured lymphocytes of normal subjects
    • Aym S., 1976., Nonrandom distribution of chromosome breaks in cultured lymphocytes of normal subjects., Hum Genet, 32: 161-75.
    • (1976) Hum Genet , vol.32 , pp. 161-175
    • Aym, S.1
  • 35
    • 0018304782 scopus 로고
    • Distribution of spontaneous chromosome breaks in man
    • Mattei MG., 1979., Distribution of spontaneous chromosome breaks in man., Cytogenet Cell Genet, 23: 95-102.
    • (1979) Cytogenet Cell Genet , vol.23 , pp. 95-102
    • Mattei, M.G.1
  • 36
    • 0015694748 scopus 로고
    • Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD., 1973., Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining., Nature, 243: 290-93.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 38
    • 67649970534 scopus 로고    scopus 로고
    • The allometry of chronic myeloid leukemia
    • Pacheco JM, Traulsen A, Dingli D., 2009., The allometry of chronic myeloid leukemia., J Theor Biol, 259: 635-40.
    • (2009) J Theor Biol , vol.259 , pp. 635-640
    • Pacheco, J.M.1    Traulsen, A.2    Dingli, D.3
  • 39
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D., 1990., Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome., Science, 247: 824-30.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 40
    • 0030932540 scopus 로고    scopus 로고
    • Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise?
    • Luzzatto L, Bessler M, Rotoli B., 1997., Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise?, Cell, 88: 1-4.
    • (1997) Cell , vol.88 , pp. 1-4
    • Luzzatto, L.1    Bessler, M.2    Rotoli, B.3
  • 41
    • 0028110863 scopus 로고
    • Mutations in the PIG-A gene causing partial deficiency of GPI-linked surface proteins (PNH II) in patients with paroxysmal nocturnal haemoglobinuria
    • Bessler M, Mason PJ, Hillmen P, Luzzatto L., 1994., Mutations in the PIG-A gene causing partial deficiency of GPI-linked surface proteins (PNH II) in patients with paroxysmal nocturnal haemoglobinuria., Br J Haematol, 87: 863-66.
    • (1994) Br J Haematol , vol.87 , pp. 863-866
    • Bessler, M.1    Mason, P.J.2    Hillmen, P.3    Luzzatto, L.4
  • 42
    • 33646527709 scopus 로고    scopus 로고
    • The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH)
    • Araten DJ, Luzzatto L., 2006., The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH)., Blood, 108: 734-36.
    • (2006) Blood , vol.108 , pp. 734-736
    • Araten, D.J.1    Luzzatto, L.2
  • 43
    • 0028299834 scopus 로고
    • Somatic mutations and cellular selection in paroxysmal nocturnal haemoglobinuria
    • Bessler M, Mason P, Hillmen P, Luzzatto L., 1994., Somatic mutations and cellular selection in paroxysmal nocturnal haemoglobinuria., Lancet, 343: 951-53.
    • (1994) Lancet , vol.343 , pp. 951-953
    • Bessler, M.1    Mason, P.2    Hillmen, P.3    Luzzatto, L.4
  • 44
    • 33646546386 scopus 로고    scopus 로고
    • The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
    • Jamieson CH, Gotlib J, Durocher JA, et al., 2006., The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation., Proc Natl Acad Sci USA, 103: 6224-29.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6224-6229
    • Jamieson, C.H.1    Gotlib, J.2    Durocher, J.A.3
  • 45
    • 33745721197 scopus 로고    scopus 로고
    • JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
    • Lacout C, Pisani DF, Tulliez M, et al., 2006., JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis., Blood, 108: 1652-60.
    • (2006) Blood , vol.108 , pp. 1652-1660
    • Lacout, C.1    Pisani, D.F.2    Tulliez, M.3
  • 46
    • 47249150213 scopus 로고    scopus 로고
    • Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs
    • Rollison DE, Howlader N, Smith MT, et al., 2008., Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs., Blood, 112: 45-52.
    • (2008) Blood , vol.112 , pp. 45-52
    • Rollison, D.E.1    Howlader, N.2    Smith, M.T.3
  • 47
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL, Wadleigh M, Cools J, et al., 2005., Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis., Cancer Cell, 7: 387-97.
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 48
    • 77958159521 scopus 로고    scopus 로고
    • Evolutionary dynamics., Cambridge: The Belknap Press of Harvard University Press.
    • Nowak MA., 2006., Evolutionary dynamics., Cambridge: The Belknap Press of Harvard University Press.
    • (2006)
    • Nowak, M.A.1
  • 49
    • 33846012829 scopus 로고    scopus 로고
    • JAK2(V617F): Prevalence in a large Chinese hospital population
    • Xu X, Zhang Q, Luo J, et al., 2007., JAK2(V617F): Prevalence in a large Chinese hospital population., Blood, 109: 339-42.
    • (2007) Blood , vol.109 , pp. 339-342
    • Xu, X.1    Zhang, Q.2    Luo, J.3
  • 50
    • 66349136312 scopus 로고    scopus 로고
    • The JAK2(V617F) tyrosine kinase mutation in blood donors with upper-limit haematocrit levels
    • Tagariello G, Di Gaetano R, Sartori R, et al., 2009., The JAK2(V617F) tyrosine kinase mutation in blood donors with upper-limit haematocrit levels., Blood Transfus, 7: 111-16.
    • (2009) Blood Transfus , vol.7 , pp. 111-116
    • Tagariello, G.1    Di Gaetano, R.2    Sartori, R.3
  • 51
    • 19944385935 scopus 로고    scopus 로고
    • MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
    • Huntly BJ, Shigematsu H, Deguchi K, et al., 2004., MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors., Cancer Cell, 6: 587-96.
    • (2004) Cancer Cell , vol.6 , pp. 587-596
    • Huntly, B.J.1    Shigematsu, H.2    Deguchi, K.3
  • 52
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    • Jamieson CH, Ailles LE, Dylla SJ, et al., 2004., Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML., N Engl J Med, 351: 657-67.
    • (2004) N Engl J Med , vol.351 , pp. 657-667
    • Jamieson, C.H.1    Ailles, L.E.2    Dylla, S.J.3
  • 53
    • 33746498580 scopus 로고    scopus 로고
    • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
    • Krivtsov AV, Twomey D, Feng Z, et al., 2006., Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9., Nature, 442: 818-22.
    • (2006) Nature , vol.442 , pp. 818-822
    • Krivtsov, A.V.1    Twomey, D.2    Feng, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.