Structural analysis of proinsulin hexamer assembly by hydroxyl radical footprinting and computational modeling

Journal of Biological Chemistry

Volumn 286, Issue 51, 2011, Pages 43710-43716

  Kiselar, Janna G ^a   Datt, Manish ^a   Chance, Mark R ^a,b   Weiss, Michael A ^c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-DOMAIN; COMPARATIVE STUDIES; COMPUTATIONAL MODELING; DIABETES MELLITUS; HEXAMERS; HYDROXYL RADICAL FOOTPRINTING; INSULIN GENE; MONOMERIC FORMS; NMR STRUCTURES; OUTER SURFACE; OXIDATION RATES; PROINSULIN; PROTEIN FOOTPRINTING; WILD TYPES;

DIMERS; GENES; MONOMERS;

INSULIN;

INSULIN; PROINSULIN;

ARTICLE; CONTROLLED STUDY; DIMERIZATION; HYDROXYL RADICAL FOOTPRINTING; MASS SPECTROMETRY; MATHEMATICAL MODEL; MOLECULAR MODEL; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOOTPRINTING; PROTEIN MODIFICATION; PROTEIN STRUCTURE; RADIOLYSIS;

COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS; DIMERIZATION; FREE RADICALS; HUMANS; INSULIN; MASS SPECTROMETRY; MODELS, MOLECULAR; MUTATION; PEPTIDES; PROINSULIN; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SOFTWARE; SOLVENTS; SYNCHROTRONS;

EID: 83755181357     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.297853     Document Type: Article

References (39)

1. Baker, E. N., Blundell, T. L., Cutfield, J. F., Cutfield, S. M., Dodson, E. J., Dodson, G. G., Hodgkin, D. M., Hubbard, R. E., Isaacs, N. W., Reynolds, C. D., et al. (1988) Philos. Trans. R. Soc. Lond. B. Biol. Sci. 319, 369-456
2. Støy, J., Edghill, E. L., Flanagan, S. E., Ye, H., Paz, V. P., Pluzhnikov, A., Below, J. E., Hayes, M. G., Cox, N. J., Lipkind, G. M., Lipton, R. B., Greeley, S. A., Patch, A. M., Ellard, S., Steiner, D. F., Hattersley, A. T., Philipson, L. H., and Bell, G. I. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 15040-15044
3. Edghill, E. L., Flanagan, S. E., Patch, A. M., Boustred, C., Parrish, A., Shields, B., Shepherd, M. H., Hussain, K., Kapoor, R. R., Malecki, M., MacDonald, M. J., Støy, J., Steiner, D. F., Philipson, L. H., Bell, G. I., Hattersley, A. T., and Ellard, S. (2008) Diabetes 57, 1034-1042
4. Colombo, C., Porzio, O., Liu, M., Massa, O., Vasta, M., Salardi, S., Beccaria, L., Monciotti, C., Toni, S., Pedersen, O., Hansen, T., Federici, L., Pesavento, R., Cadario, F., Federici, G., Ghirri, P., Arvan, P., Iafusco, D., and Barbetti, F. (2008) J. Clin. Invest. 118, 2148-2156
5. Liu, M., Hodish, I., Rhodes, C. J., and Arvan, P. (2007) Proc. Natl. Acad. Sci U.S.A. 104, 15841-15846
6. Adams, M. J., Haas, D. J., Jeffery, B. A., McPherson, A., Jr., Mermall, H. L., Rossmann, M. G., Schevitz, R. W., and Wonacott, A. J. (1969) J. Mol. Biol. 41, 159-188
7. Maleknia, S. D., Brenowitz, M., and Chance, M. R. (1999) Anal. Chem. 71, 3965-3973
8. Takamoto, K., and Chance, M. R. (2006) Annu. Rev. Biophys. Biomol. Struct. 35, 251-276
9. Aguilar, C. F., Cronin, N. B., Badasso, M., Dreyer, T., Newman, M. P., Cooper, J. B., Hoover, D. J., Wood, S. P., Johnson, M. S., and Blundell, T. L. (1997) J. Mol. Biol. 267, 899-915
10. Yang, Y., Hua, Q. X., Liu, J., Shimizu, E. H., Choquette, M. H., Mackin, R. B., and Weiss, M. A. (2010) J. Biol. Chem. 285, 7847-7851
11. Steiner, D. F. (2004) Exp. Diabesity Res. 5, 7-14
12. Kiselar, J. G., Maleknia, S. D., Sullivan, M., Downard, K. M., and Chance, M. R. (2002) Int. J. Radiat. Biol. 78, 101-114
13. Hua, Q. X., Hu, S. Q., Jia, W., Chu, Y. C., Burke, G. T., Wang, S. H., Wang, R. Y., Katsoyannis, P. G., and Weiss, M. A. (1998) J. Mol. Biol. 277, 103-118
14. Weiss, M. A. (2009) J. Biol. Chem. 284, 19159-19163
15. Weiss, M. A., Hua, Q. X., Lynch, C. S., Frank, B. H., and Shoelson, S. E. (1991) Biochemistry 30, 7373-7389
16. Gupta, S., Sullivan, M., Toomey, J., Kiselar, J., and Chance, M. R. (2007) J. Synchrotron Radiat. 14, 233-243
17. Berman, H. M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T. N., Weissig, H., Shindyalov, I. N., and Bourne, P. E. (2000) Nucleic Acids Res. 28, 235-242
18. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
19. Kleywegt, G. J. (1996) Acta Crystallogr. D Biol. Crystallogr. 52, 842-857
20. Dong, J., Wan, Z., Popov, M., Carey, P. R., and Weiss, M. A. (2003) J. Mol. Biol. 330, 431-442
21. Davies MJ, Dean, R. T. (eds) (1997) Radical-mediated Protein Oxidation: From Chemistry to Medicine, Oxford University Press USA, New York, NY
22. Guan, J. Q., Vorobiev, S., Almo, S. C., and Chance, M. R. (2002) Biochemistry 41, 5765-5775
23. Xu, G., and Chance, M. R. (2007) Chem. Rev. 107, 3514-3543
24. Ye, J., Chang, W., and Liang, D. (2001) Biochim. Biophys. Acta 1547, 18-25
25. Zoete, V., Meuwly, M., and Karplus, M. (2004) J. Mol. Biol. 342, 913-929
26. Hayes, M. G., Pluzhnikov, A., Miyake, K., Sun, Y., Ng, M. C., Roe, C. A., Below, J. E., Nicolae, R. I., Konkashbaev, A., Bell, G. I., Cox, N. J., and Hanis, C. L. (2007) Diabetes 56, 3033-3044
27. Izumi, T., Yokota-Hashimoto, H., Zhao, S., Wang, J., Halban, P. A., and Takeuchi, T. (2003) Diabetes 52, 409-416
28. Weiss, M. A., Hua, Q. X., Jia, W., Chu, Y. C., Wang, R. Y., and Katsoyannis, P. G. (2000) Biochemistry 39, 15429-15440
29. Nakagawa, S. H., Hua, Q. X., Hu, S. Q., Jia, W., Wang, S., Katsoyannis, P. G., and Weiss, M. A. (2006) J. Biol. Chem. 281, 22386-22396
30. Hua, Q. X., Nakagawa, S. H., Jia, W., Hu, S. Q., Chu, Y. C., Katsoyannis, P. G., and Weiss, M. A. (2001) Biochemistry 40, 12299-12311
31. Chu, Y. C., Wang, R. Y., Burke, G. T., Chanley, J. D., and Katsoyannis, P. G. (1987) Biochemistry 26, 6975-6979
32. Kristensen, C., Kjeldsen, T., Wiberg, F. C., Schäffer, L., Hach, M., Havelund, S., Bass, J., Steiner, D. F., and Andersen, A. S. (1997) J. Biol. Chem. 272, 12978-12983
33. Molven, A., Ringdal, M., Nordbø, A. M., Raeder, H., Støy, J., Lipkind, G. M., Steiner, D. F., Philipson, L. H., Bergmann, I., Aarskog, D., Undlien, D. E., Joner, G., Søvik, O., Bell, G. I., and Njølstad, P. R. (2008) Diabetes 57, 1131-1135
34. Zoete, V., and Meuwly, M. (2006) J. Comput. Chem. 27, 1843-1857
35. Hua, Q. X., Liu, M., Hu, S. Q., Jia, W., Arvan, P., and Weiss, M. A. (2006) J. Biol. Chem. 281, 24889-24899
36. Takamoto, K., Kamal, J. K., and Chance, M. R. (2007) Structure 15, 39-51
37. Kiselar, J. G., Janmey, P. A., Almo, S. C., and Chance, M. R. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 3942-3947
38. Kiselar, J. G., Mahaffy, R., Pollard, T. D., Almo, S. C., and Chance, M. R. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 1552-1557
39. Gupta, S., Cheng, H., Mollah, A. K., Jamison, E., Morris, S., Chance, M. R., Khrapunov, S., and Brenowitz, M. (2007) Biochemistry 46, 9886-9898