Insulin assembly damps conformational fluctuations: Raman analysis of amide I linewidths in native states and fibrils

Journal of Molecular Biology

Volumn 330, Issue 2, 2003, Pages 431-442

  Dong, Jian ^a   Wan, Zhuli ^a   Popov, Maxim ^a,b   Carey, Paul R ^a   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Peptide hormone; Protein crystallography; Protein dynamics; Protein structure; Raman spectroscopy

Indexed keywords

AMIDE; AMIDE 1; DIMER; INSULIN; MONOMER; OLIGOMER; POLYPEPTIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DIMERIZATION; FIBER; MICROSCOPY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE; RAMAN SPECTROMETRY; SIMULATION; STRUCTURE ANALYSIS;

EID: 0038461955     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00536-9     Document Type: Article

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