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Volumn 338, Issue 2, 2011, Pages 466-475

A calcineurin-independent mechanism of angiogenesis inhibition by a nonimmunosuppressive cyclosporin A analog

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLOPHILIN; CYCLOPHILIN INHIBITOR; CYCLOSPORIN A DERIVATIVE;

EID: 79960475065     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.180851     Document Type: Article
Times cited : (20)

References (40)
  • 1
    • 0033019518 scopus 로고    scopus 로고
    • Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: A role for tissue factor gene expression
    • Armesilla AL, Lorenzo E, Gómez del Arco P, Martínez- Martínez S, Alfranca A, and Redondo JM (1999) Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression. Mol Cell Biol 19:2032-2043. (Pubitemid 29098261)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.3 , pp. 2032-2043
    • Armesilla, A.L.1    Lorenzo, E.2    Del, A.P.G.3    Martinez-Martinez, S.4    Alfranca, A.5    Redondo, J.M.6
  • 3
    • 21244446551 scopus 로고    scopus 로고
    • Properties of the permeability transition pore in mitochondria devoid of cyclophilin D
    • DOI 10.1074/jbc.C500089200
    • Basso E, Fante L, Fowlkes J, Petronilli V, Forte MA, and Bernardi P (2005) Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J Biol Chem 280:18558-18561. (Pubitemid 41379552)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.19 , pp. 18558-18561
    • Basso, E.1    Fante, L.2    Fowlkes, J.3    Petronilli, V.4    Forte, M.A.5    Bernardi, P.6
  • 5
    • 0017157814 scopus 로고
    • Biological effects of cyclosporin A: A new antilymphocytic agent
    • Borel JF, Feurer C, Gubler HU, and Stähelin H (1976) Biological effects of cyclosporin A: a new antilymphocytic agent. Agents Actions 6:468-475.
    • (1976) Agents Actions , vol.6 , pp. 468-475
    • Borel, J.F.1    Feurer, C.2    Gubler, H.U.3    Stähelin, H.4
  • 6
    • 0027323876 scopus 로고
    • Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: Roles of calcineurin binding and cellular location
    • Bram RJ, Hung DT, Martin PK, Schreiber SL, and Crabtree GR (1993) Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol 13:4760-4769. (Pubitemid 23220381)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.8 , pp. 4760-4769
    • Bram, R.J.1    Hung, D.T.2    Martin, P.K.3    Schreiber, S.L.4    Crabtree, G.R.5
  • 7
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9:653-660.
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 8
    • 4143074548 scopus 로고    scopus 로고
    • + T cells via a proline-directed conformational switch in Itk
    • DOI 10.1016/j.immuni.2004.07.005, PII S107476130400192X
    • Colgan J, Asmal M, Neagu M, Yu B, Schneidkraut J, Lee Y, Sokolskaja E, Andreotti A, and Luban J (2004) Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. Immunity 21:189-201. (Pubitemid 39094049)
    • (2004) Immunity , vol.21 , Issue.2 , pp. 189-201
    • Colgan, J.1    Asmal, M.2    Neagu, M.3    Yu, B.4    Schneidkraut, J.5    Lee, Y.6    Sokolskaja, E.7    Andreotti, A.8    Luban, J.9
  • 9
    • 0028342952 scopus 로고
    • Signal transmission between the plasma membrane and nucleus of T lymphocytes
    • Crabtree GR and Clipstone NA (1994) Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu Rev Biochem 63:1045-1083. (Pubitemid 24218655)
    • (1994) Annual Review of Biochemistry , vol.63 , pp. 1045-1083
    • Crabtree, G.R.1    Clipstone, N.A.2
  • 11
    • 0034660683 scopus 로고    scopus 로고
    • A noncommercial dual luciferase enzyme assay system for reporter gene analysis
    • DOI 10.1006/abio.2000.4605
    • Dyer BW, Ferrer FA, Klinedinst DK, and Rodriguez R (2000) A noncommercial dual luciferase enzyme assay system for reporter gene analysis. Anal Biochem 282:158-161. (Pubitemid 30409441)
    • (2000) Analytical Biochemistry , vol.282 , Issue.1 , pp. 158-161
    • Dyer, B.W.1    Ferrer, F.A.2    Klinedinst, D.K.3    Rodriguez, R.4
  • 12
    • 0024959449 scopus 로고
    • Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins
    • Fischer G, Wittmann-Liebold B, Lang K, Kiefhaber T, and Schmid FX (1989) Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature 337:476-478.
    • (1989) Nature , vol.337 , pp. 476-478
    • Fischer, G.1    Wittmann-Liebold, B.2    Lang, K.3    Kiefhaber, T.4    Schmid, F.X.5
  • 14
    • 0035809312 scopus 로고    scopus 로고
    • Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: Roles of the nuclear factor of activated T cells and cyclooxygenase 2
    • DOI 10.1084/jem.193.5.607
    • Hernández GL, Volpert OV, Iñiguez MA, Lorenzo E, Martínez-Martínez S, Grau R, Fresno M, and Redondo JM (2001) Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2. J Exp Med 193:607-620. (Pubitemid 32539557)
    • (2001) Journal of Experimental Medicine , vol.193 , Issue.5 , pp. 607-620
    • Hernandez, G.L.1    Volpert, O.V.2    Iniguez, M.A.3    Lorenzo, E.4    Martinez-Martinez, S.5    Grau, R.6    Fresno, M.7    Redondo, J.M.8
  • 15
    • 70349782389 scopus 로고    scopus 로고
    • An overview of small-molecule inhibitors of VEGFR signaling
    • Ivy SP, Wick JY, and Kaufman BM (2009) An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 6:569-579.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 569-579
    • Ivy, S.P.1    Wick, J.Y.2    Kaufman, B.M.3
  • 16
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • DOI 10.1038/ncponc0403, PII N0403
    • Jain RK, Duda DG, Clark JW, and Loeffler JS (2006) Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 3:24-40. (Pubitemid 43108832)
    • (2006) Nature Clinical Practice Oncology , vol.3 , Issue.1 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 17
    • 0031572824 scopus 로고    scopus 로고
    • A protease-free assay for peptidyl prolyl cis/trans isomerases using standard peptide substrates
    • Janowski B, Wöllner S, Schutkowski M, and Fischer G (1997) A protease-free assay for peptidyl prolyl cis/trans isomerases using standard peptide substrates. Anal Biochem 252:299-307.
    • (1997) Anal Biochem , vol.252 , pp. 299-307
    • Janowski, B.1    Wöllner, S.2    Schutkowski, M.3    Fischer, G.4
  • 18
    • 0037449818 scopus 로고    scopus 로고
    • NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells
    • DOI 10.1074/jbc.M210250200
    • Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, and Bischoff J (2003) NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells. J Biol Chem 278:1686-1692. (Pubitemid 36801401)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.3 , pp. 1686-1692
    • Johnson, E.N.1    Lee, Y.M.2    Sander, T.L.3    Rabkin, E.4    Schoen, F.J.5    Kaushal, S.6    Bischoff, J.7
  • 20
    • 0037427440 scopus 로고    scopus 로고
    • Mitochondrial permeability transition: A common pathway to necrosis and apoptosis
    • DOI 10.1016/S0006-291X(03)00618-1
    • Kim JS, He L, and Lemasters JJ (2003) Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun 304:463-470. (Pubitemid 36506518)
    • (2003) Biochemical and Biophysical Research Communications , vol.304 , Issue.3 , pp. 463-470
    • Kim, J.-S.1    He, L.2    Lemasters, J.J.3
  • 21
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, and Schreiber SL (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807-815. (Pubitemid 121001714)
    • (1991) Cell , vol.66 , Issue.4 , pp. 807-815
    • Liu, J.1    Farmer Jr., J.O.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 22
    • 61849085112 scopus 로고    scopus 로고
    • Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation
    • Liu JO (2009) Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation. Immunol Rev 228:184-198.
    • (2009) Immunol Rev , vol.228 , pp. 184-198
    • Liu, J.O.1
  • 23
    • 15844407874 scopus 로고    scopus 로고
    • Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
    • DOI 10.1038/nature03317
    • Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T, and Tsujimoto Y (2005) Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 434:652-658. (Pubitemid 40488558)
    • (2005) Nature , vol.434 , Issue.7033 , pp. 652-658
    • Nakagawa, T.1    Shimizu, S.2    Watanabe, T.3    Yamaguchi, O.4    Otsu, K.5    Yamagata, H.6    Inohara, H.7    Kubo, T.8    Tsujimoto, Y.9
  • 24
    • 0030051609 scopus 로고    scopus 로고
    • Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin A-sensitive channel
    • DOI 10.1074/jbc.271.4.2185
    • Nicolli A, Basso E, Petronilli V, Wenger RM, and Bernardi P (1996) Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel. J Biol Chem 271:2185-2192. (Pubitemid 26047809)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.4 , pp. 2185-2192
    • Nicolli, A.1    Basso, E.2    Petronilli, V.3    Wenger, R.M.4    Bernardi, P.5
  • 25
    • 0029101382 scopus 로고
    • The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor
    • Owens-Grillo JK, Hoffmann K, Hutchison KA, Yem AW, Deibel MR Jr, Handschumacher RE, and Pratt WB (1995) The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor. J Biol Chem 270:20479-20484.
    • (1995) J Biol Chem , vol.270 , pp. 20479-20484
    • Owens-Grillo, J.K.1    Hoffmann, K.2    Hutchison, K.A.3    Yem, A.W.4    Deibel Jr., M.R.5    Handschumacher, R.E.6    Pratt, W.B.7
  • 26
    • 0028294407 scopus 로고
    • Calcineurin has a very tight-binding pocket for the side chain of residue 4 of cyclosporin
    • DOI 10.1016/S0960-894X(01)80127-X
    • Papageorgiou C, Borer X, and French RR (1994) Calcineurin has a very tight-binding pocket for the side chain of residue 4 of cyclosporin. Bioorg Med Chem Lett 4:267-272. (Pubitemid 24127119)
    • (1994) Bioorganic and Medicinal Chemistry Letters , vol.4 , Issue.2 , pp. 267-272
    • Papageorgiou, C.1    Borer, X.2    French, R.R.3
  • 27
    • 0026495179 scopus 로고
    • A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor
    • Passaniti A, Taylor RM, Pili R, Guo Y, Long PV, Haney JA, Pauly RR, Grant DS, and Martin GR (1992) A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 67:519-528.
    • (1992) Lab Invest , vol.67 , pp. 519-528
    • Passaniti, A.1    Taylor, R.M.2    Pili, R.3    Guo, Y.4    Long, P.V.5    Haney, J.A.6    Pauly, R.R.7    Grant, D.S.8    Martin, G.R.9
  • 28
    • 33751562062 scopus 로고    scopus 로고
    • Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling
    • Rafiee P, Heidemann J, Ogawa H, Johnson NA, Fisher PJ, Li MS, Otterson MF, Johnson CP, and Binion DG (2004) Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling. Cell Commun Signal 2:3.
    • (2004) Cell Commun Signal , vol.2 , pp. 3
    • Rafiee, P.1    Heidemann, J.2    Ogawa, H.3    Johnson, N.A.4    Fisher, P.J.5    Li, M.S.6    Otterson, M.F.7    Johnson, C.P.8    Binion, D.G.9
  • 29
    • 0030973579 scopus 로고    scopus 로고
    • Transcription factors of the NFAT family: Regulation and function
    • DOI 10.1146/annurev.immunol.15.1.707
    • Rao A, Luo C, and Hogan PG (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15:707-747. (Pubitemid 27169297)
    • (1997) Annual Review of Immunology , vol.15 , pp. 707-747
    • Rao, A.1    Luo, C.2    Hogan, P.G.3
  • 30
    • 67650735143 scopus 로고    scopus 로고
    • Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells
    • Rinne A, Banach K, and Blatter LA (2009) Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells. J Mol Cell Cardiol 47:400-410.
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 400-410
    • Rinne, A.1    Banach, K.2    Blatter, L.A.3
  • 33
    • 0024454699 scopus 로고
    • Cyclosporine inhibits basic fibroblast growth factor-driven proliferation of human endothelial cells and keratinocytes
    • DOI 10.1001/archderm.125.10.1359
    • Sharpe RJ, Arndt KA, Bauer SI, and Maione TE (1989) Cyclosporine inhibits basic fibroblast growth factor-driven proliferation of human endothelial cells and keratinocytes. Arch Dermatol 125:1359-1362. (Pubitemid 19252850)
    • (1989) Archives of Dermatology , vol.125 , Issue.10 , pp. 1359-1362
    • Sharpe, R.J.1    Arndt, K.A.2    Bauer, S.I.3    Maione, T.E.4
  • 38
    • 0023205561 scopus 로고
    • A pragmatic approach to the analysis of DNA histograms with a definable G1 peak
    • Watson JV, Chambers SH, and Smith PJ (1987) A pragmatic approach to the analysis of DNA histograms with a definable G1 peak. Cytometry 8:1-8.
    • (1987) Cytometry , vol.8 , pp. 1-8
    • Watson, J.V.1    Chambers, S.H.2    Smith, P.J.3
  • 39
    • 77957752614 scopus 로고    scopus 로고
    • Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice
    • Wissing ER, Millay DP, Vuagniaux G, and Molkentin JD (2010) Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice. Neuromuscul Disord 20:753-760.
    • (2010) Neuromuscul Disord , vol.20 , pp. 753-760
    • Wissing, E.R.1    Millay, D.P.2    Vuagniaux, G.3    Molkentin, J.D.4
  • 40


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