Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: Volume of distribution at steady state

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 7, 2003, Pages 939-949

  Wajima, Toshihiro ^a   Fukumura, Kazuya ^a   Yano, Yoshitaka ^a   Oguma, Takayoshi ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CARBAMOYLOXYETHYLTHIO) 6 (1 HYDROXYETHYL)PENEM 3 CARBOXYLIC ACID; ASULACRINE ISETHIONATE; BIAPENEM; CEFAZOLIN; CEFCLIDIN; CEFMENOXIME; CEFMETAZOLE; CEFODIZIME; CEFOPERAZONE; CEFOTETAN; CEFOTIAM; CEFOZOPRAN; CEFPIRAMIDE; CEFPIROME; CEFTAZIDIME; CEFTIZOXIME; CEFTRIAXONE; CEFUZONAM; FLOMOXEF; FOSMIDOMYCIN; GAVESTINEL; INCADRONIC ACID; LAMIFIBAN; LATAMOXEF; NAPSAGATRAN; PIDOTIMOD; RITIPENEM; TOLCAPONE; UNINDEXED DRUG; VALPROIC ACID;

ALLOMETRY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG DISTRIBUTION; EXPERIMENTAL MODEL; HUMAN; HYDROGEN BOND; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; MONKEY; MOUSE; MULTIVARIATE ANALYSIS; NONHUMAN; PARTITION COEFFICIENT; PREDICTION; RABBIT; RAT; REGRESSION ANALYSIS; STEADY STATE;

ANIMALS; DOGS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; MULTIVARIATE ANALYSIS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RATS; REGRESSION ANALYSIS;

EID: 0041664968     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021477     Document Type: Article

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