Interspecies prediction of human drug clearance based on scaling data from one or two animal species

Drug Metabolism and Disposition

Volumn 35, Issue 10, 2007, Pages 1886-1893

  Tang, Huadong ^a   Hussain, Azher ^a   Leal, Mauricio ^a   Mayersohn, Michael ^b   Fluhler, Eric ^a  

^a WYETH RESEARCH   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOMETRY; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG CLEARANCE; LIVER BLOOD FLOW; MONKEY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

ANIMALS; DOGS; HAPLORHINI; HUMANS; METABOLIC CLEARANCE RATE; MICE; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RATS; SPECIES SPECIFICITY;

ANIMALIA; CANIS FAMILIARIS; RATTUS;

EID: 34748919740     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.016188     Document Type: Article

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