Correlation of plasma clearance of 54 extensively metabolized drugs between humans and rats: Mean allometric coefficient of 0.66

Pharmaceutical Research

Volumn 15, Issue 9, 1998, Pages 1474-1479

  Chiou, Win L ^a   Robbie, Gabriel ^a   Chung, Sang Mock ^a   Wu, Ta Chen ^a   Ma, Chien ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Allometric analysis; Interspecies scale up in plasma clearance; Pharmacokinetics; Plasma clearance; Rat vs. human; Unbound plasma clearance

Indexed keywords

AGENTS AFFECTING METABOLISM; ANALGESIC AGENT; ANESTHETIC AGENT; ANTIBIOTIC AGENT; BRONCHODILATING AGENT; CAFFEINE; CARDIOVASCULAR AGENT; DIGESTIVE TRACT AGENT; DRUG; HORMONE; PSYCHOTROPIC AGENT;

ALLOMETRY; ANALYTIC METHOD; ARTICLE; DRUG CLEARANCE; DRUG METABOLISM; HUMAN; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT;

ANIMALS; HUMANS; METABOLIC CLEARANCE RATE; MODELS, THEORETICAL; PHARMACOKINETICS; RATS; SPECIES SPECIFICITY; STATISTICS;

EID: 0031723045     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011974226596     Document Type: Article

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