Pharmacokinetics of NS-49, a phenethylamine class α(1A)-adrenoceptor agonist, at therapeutic doses in several animal species and interspecies scaling of its pharmacokinetic parameters

International Journal of Pharmaceutics

Volumn 186, Issue 2, 1999, Pages 215-222

  Mukai, Hideya ^a   Watanabe, Shuji ^a   Tsuchida, Keiko ^a   Morino, Akira ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

(1A) Adrenoceptor agonist; Interspecies scaling; NS 49; Pharmacokinetics

Indexed keywords

3' (2 AMINO 1 HYDROXYETHYL) 4' FLUOROMETHANESULFONANILIDE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; PHENETHYLAMINE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG HALF LIFE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RABBIT; RAT;

ADRENERGIC ALPHA-AGONISTS; ALGORITHMS; ANILIDES; ANIMALS; BODY WEIGHT; DOGS; HUMANS; INDICATORS AND REAGENTS; KIDNEY; MALE; MODELS, BIOLOGICAL; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RENAL CIRCULATION; SPECIES SPECIFICITY;

EID: 0032885675     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00184-2     Document Type: Article

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