Caffeine modulates phosphorylation of insulin receptor substrate-1 and impairs insulin signal transduction in rat skeletal muscle

Journal of Applied Physiology

Volumn 111, Issue 6, 2011, Pages 1629-1636

  Egawa, Tatsuro ^a   Tsuda, Satoshi ^a   Ma, Xiao ^a   Hamada, Taku ^b   Hayashi, Tatsuya ^a  

^a KYOTO UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY OF HEALTH AND SPORT SCIENCES   (Japan)

Author keywords

5= AMP activated protein kinase; Akt; Inhibitor B kinase; P70 S6 kinase; Serine phosphorylation

Indexed keywords

CAFFEINE; I KAPPA B KINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, RAT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; TYROSINE;

ANIMAL; ARTICLE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; IN VITRO STUDY; MALE; METABOLISM; PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT;

ANIMALS; CAFFEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; I-KAPPA B KINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MALE; MUSCLE, SKELETAL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SERINE; SIGNAL TRANSDUCTION; TYROSINE;

EID: 83655193443     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00249.2011     Document Type: Article

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