Exploring the role of miRNAs in renal cell carcinoma progression and metastasis through bioinformatic and experimental analyses

Tumor Biology

Volumn 33, Issue 1, 2012, Pages 131-140

  Khella, Heba W Z ^a,b   White, Nicole M A ^a,b   Faragalla, Hala ^a,b   Gabril, Manal ^c   Boazak, Mina ^a   Dorian, David ^a   Khalil, Bishoy ^a   Antonios, Hany ^a   Bao, Tian Tian ^a   Pasic, Maria D ^b   Honey, R John ^d   Stewart, Robert ^d   Pace, Kenneth T ^d   Bjarnason, Georg A ^e   Jewett, Michael A S ^f   Yousef, George M ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c LONDON HEALTH SCIENCES CENTRE   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

Metastasis; MicroRNA; Prognosis; Renal cell carcinoma; Tumour markers; VEGF A

Indexed keywords

MICRORNA; MICRORNA 126; RNA; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ARTICLE; BIOINFORMATICS; CANCER GROWTH; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; METASTASIS; MICROARRAY ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 83655184642     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-011-0255-5     Document Type: Article

References (62)

1. WH Chow LM Dong SS Devesa 2010 Epidemiology and risk factors for kidney cancer Nat Rev Urol 7 245 257 20448658 10.1038/nrurol.2010.46
2. A Jemal R Siegel J Xu E Ward 2010 Cancer statistics, 2010 CA Cancer J Clin 60 277 300 20610543 10.3322/caac.20073
3. M Remzi E Javadli M Ozsoy 2010 Management of small renal masses: a review World J Urol 28 275 281 20177900 10.1007/s00345-010-0516-8
4. RH Weiss PY Lin 2006 Kidney cancer: identification of novel targets for therapy Kidney Int 69 224 232 16408110 10.1038/sj.ki.5000065 1:CAS:528:DC%2BD28XksVKqtg%3D%3D (Pubitemid 43323071)
5. CL Chaffer RA Weinberg 2011 A perspective on cancer cell metastasis Science 331 1559 1564 21436443 10.1126/science.1203543 1:CAS:528: DC%2BC3MXjs1Cgtbo%3D
6. D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 100 57 70 10647931 10.1016/S0092-8674(00)81683-9 1:CAS:528:DC%2BD3cXks1CktA%3D%3D (Pubitemid 30046295)
7. D Hanahan RA Weinberg 2011 Hallmarks of cancer: the next generation Cell 144 646 674 21376230 10.1016/j.cell.2011.02.013 1:CAS:528:DC%2BC3MXjsFeqtrk%3D
8. C Coghlin GI Murray 2010 Current and emerging concepts in tumour metastasis J Pathol 222 1 15 20681009 10.1002/path.2727 1:CAS:528: DC%2BC3cXhtFGnurzO
9. CA Klein 2009 Parallel progression of primary tumours and metastases Nat Rev Cancer 9 302 312 19308069 10.1038/nrc2627 1:CAS:528:DC%2BD1MXjsFSrsr8%3D
10. KW Hunter NP Crawford J Alsarraj 2008 Mechanisms of metastasis Breast Cancer Res 10 Suppl 1 S2 19091006 10.1186/bcr1988
11. MY Kim T Oskarsson S Acharyya DX Nguyen XH Zhang L Norton J Massague 2009 Tumor self-seeding by circulating cancer cells Cell 139 1315 1326 20064377 10.1016/j.cell.2009.11.025
12. NM White E Fatoohi M Metias K Jung C Stephan GM Yousef 2011 Metastamirs: a stepping stone towards improved cancer management Nat Rev Clin Oncol 8 75 84 21045789 10.1038/nrclinonc.2010.173 1:CAS:528:DC%2BC3MXht1yrtL4%3D
13. L Santarpia M Nicoloso GA Calin 2010 MicroRNAs: a complex regulatory network drives the acquisition of malignant cell phenotype Endocr Relat Cancer 17 F51 F75 19843580 10.1677/ERC-09-0222 1:CAS:528:DC%2BC3cXksVylur0%3D
14. G Sotiropoulou G Pampalakis E Lianidou Z Mourelatos 2009 Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell RNA 15 1443 1461 19561119 10.1261/rna.1534709 1:CAS:528:DC%2BD1MXpsFOlurs%3D
15. TF Chow YM Youssef E Lianidou AD Romaschin RJ Honey R Stewart KT Pace GM Yousef 2010 Differential expression profiling of microRNAs and their potential involvement in renal cell carcinoma pathogenesis Clin Biochem 43 150 158 19646430 10.1016/j.clinbiochem.2009.07.020 1:CAS:528:DC%2BC3cXoslam
16. M Jung HJ Mollenkopf C Grimm I Wagner M Albrecht T Waller C Pilarsky M Johannsen C Stephan H Lehrach W Nietfeld T Rudel K Jung G Kristiansen 2009 MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy J Cell Mol Med 13 3918 3928 19228262 10.1111/j.1582-4934.2009.00705.x
17. L Weng X Wu H Gao B Mu X Li JH Wang C Guo JM Jin Z Chen M Covarrubias YC Yuan LM Weiss H Wu 2010 MicroRNA profiling of clear cell renal cell carcinoma by whole-genome small RNA deep sequencing of paired frozen and formalin-fixed, paraffin-embedded tissue specimens J Pathol 222 41 51 20593407 1:CAS:528:DC%2BC3cXhtFGnurzK
18. NM White TT Bao J Grigull YM Youssef A Girgis M Diamandis E Fatoohi M Metias RJ Honey R Stewart KT Pace GA Bjarnason GM Yousef 2011 miRNA profiling for clear cell renal cell carcinoma: biomarker discovery and identification of potential controls and consequences of miRNA dysregulation J Urol. 186 3 1077 1083 21784468 10.1016/j.juro.2011.04.110 1:CAS:528:DC%2BC3MXhtVWmtLvM
19. YM Youssef NM White J Grigull A Krizova C Samy S Mejia-Guerrero A Evans GM Yousef 2011 Accurate molecular classification of kidney cancer subtypes using microRNA signature Eur Urol 59 721 730 21272993 10.1016/j.eururo.2011.01.004 1:CAS:528:DC%2BC3MXkt1akur0%3D
20. TF Chow M Mankaruos A Scorilas Y Youssef A Girgis S Mossad S Metias Y Rofael RJ Honey R Stewart KT Pace GM Yousef 2010 The miR-17-92 cluster is over expressed in and has an oncogenic effect on renal cell carcinoma J Urol 183 743 751 20022054 10.1016/j.juro.2009.09.086 1:CAS:528:DC%2BC3cXitVSrtbk%3D
21. A Fendler C Stephan GM Yousef K Jung 2011 MicroRNAs as regulators of signal transduction in urological tumors Clin Chem 57 954 968 21632885 10.1373/clinchem.2010.157727 1:CAS:528:DC%2BC3MXovVKgsrk%3D
22. CS Neal MZ Michael LH Rawlings MB Van der Hoek JM Gleadle 2010 The VHL-dependent regulation of microRNAs in renal cancer BMC Med 8 64 20964835 10.1186/1741-7015-8-64
23. NM White A Bui S Mejia-Guerrero J Chao A Soosaipillai Y Youssef M Mankaruos RJ Honey R Stewart KT Pace L Sugar EP Diamandis J Dore GM Yousef 2010 Dysregulation of kallikrein-related peptidases in renal cell carcinoma: potential targets of miRNAs Biol Chem 391 411 423 20180642 10.1515/BC.2010.041 1:CAS:528:DC%2BC3cXksFKrt70%3D
24. M Redova M Svoboda O Slaby 2011 MicroRNAs and their target gene networks in renal cell carcinoma Biochem Biophys Res Commun 405 153 156 21232526 10.1016/j.bbrc.2011.01.019 1:CAS:528:DC%2BC3MXhvFKmt74%3D
25. NM White GM Yousef 2010 MicroRNAs: exploring a new dimension in the pathogenesis of kidney cancer BMC Med 8 65 20964839 10.1186/1741-7015-8-65
26. J Heinzelmann B Henning J Sanjmyatav N Posorski T Steiner H Wunderlich MR Gajda K Junker 2011 Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma World J Urol 29 367 373 21229250 10.1007/s00345-010-0633-4 1:CAS:528:DC%2BC3MXmsVequ70%3D
27. White NMA, Khella HWZ, Grigull J, Adzovic S, Youssef YM, Honey RJ, Stewart R, Pace KT, Bjarnason GA, Jewett MAS, Evans AJ, Gabril M, Yousef GM. miRNA profiling in metastatic renal cell carcinoma reveals a tumour suppressor effect for miR-215. Br J Cancer. 2011, in press.
28. P Sethupathy M Megraw AG Hatzigeorgiou 2006 A guide through present computational approaches for the identification of mammalian microRNA targets Nat Methods 3 881 886 17060911 10.1038/nmeth954 1:CAS:528:DC%2BD28XhtFSms7nE (Pubitemid 44614721)
29. S Baskerville DP Bartel 2005 Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes RNA 11 241 247 15701730 10.1261/rna.7240905 1:CAS:528:DC%2BD2MXhvVCjt7o%3D (Pubitemid 40270816)
30. C Blenkiron LD Goldstein NP Thorne I Spiteri SF Chin MJ Dunning NL Barbosa-Morais AE Teschendorff AR Green IO Ellis S Tavare C Caldas EA Miska 2007 MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype Genome Biol 8 R214 17922911 10.1186/gb-2007-8-10-r214 (Pubitemid 351917463)
31. JW Harbour MD Onken ED Roberson S Duan L Cao LA Worley ML Council KA Matatall C Helms AM Bowcock 2010 Frequent mutation of BAP1 in metastasizing uveal melanomas Science 330 1410 1413 21051595 10.1126/science.1194472 1:CAS:528:DC%2BC3cXhsVyrsbbI
32. PL Paris S Sridharan AB Hittelman Y Kobayashi S Perner G Huang J Simko P Carroll MA Rubin C Collins 2009 An oncogenic role for the multiple endocrine neoplasia type 1 gene in prostate cancer Prostate Cancer Prostatic Dis 12 184 191 18779856 10.1038/pcan.2008.45 1:CAS:528:DC%2BD1MXls12gtbk%3D
33. MJ Bueno M Malumbres 2011 MicroRNAs and the cell cycle Biochim Biophys Acta 1812 592 601 21315819 1:CAS:528:DC%2BC3MXjsFCnu7k%3D
34. B Liu XC Peng XL Zheng J Wang YW Qin 2009 MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo Lung Cancer 66 169 175 19223090 10.1016/j.lungcan.2009.01.010
35. N Zhu D Zhang H Xie Z Zhou H Chen T Hu Y Bai Y Shen W Yuan Q Jing Y Qin 2011 Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2 Mol Cell Biochem 351 157 164 21249429 10.1007/s11010-011-0723-7 1:CAS:528:DC%2BC3MXjvFejur0%3D
36. MJ Chuang KH Sun SJ Tang MW Deng YH Wu JS Sung TL Cha GH Sun 2008 Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells Cancer Sci 99 905 913 18294286 10.1111/j.1349-7006.2008.00756.x 1:CAS:528:DC%2BD1cXlslCrsbk%3D (Pubitemid 351997592)
37. R Polanski HE Warburton A Ray-Sinha T Devling H Pakula CP Rubbi N Vlatkovic MT Boyd 2010 MDM2 promotes cell motility and invasiveness through a RING-finger independent mechanism FEBS Lett 584 4695 4702 21034743 10.1016/j.febslet.2010.10.049 1:CAS:528:DC%2BC3cXhsVans73M
38. Y Mizutani H Wada O Yoshida M Fukushima M Nakao T Miki 2003 Significance of thymidine kinase activity in renal cell carcinoma J Urol 169 706 709 12544347 10.1016/S0022-5347(05)63997-3 1:CAS:528:DC%2BD3sXmtl2ktw%3D%3D (Pubitemid 36133027)
39. R Chhabra R Dubey N Saini 2010 Cooperative and individualistic functions of the microRNAs in the miR-23a 27a 24-2 cluster and its implication in human diseases Mol Cancer 9 232 20815877 10.1186/1476-4598-9-232
40. F Pichiorri SS Suh A Rocci LL De C Taccioli R Santhanam W Zhou DM Benson Jr C Hofmainster H Alder M Garofalo LG Di S Volinia HJ Lin D Perrotti M Kuehl RI Aqeilan A Palumbo CM Croce 2010 Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development Cancer Cell 18 367 381 20951946 10.1016/j.ccr.2010.09.005 1:CAS:528:DC%2BC3cXhtlSnu77F
41. S Griffiths-Jones 2007 Annotating noncoding RNA genes Annu Rev Genom Hum Genet 8 279 298 10.1146/annurev.genom.8.080706.092419 1:CAS:528: DC%2BD2sXht1WksrrP
42. R Girijadevi VC Sreedevi JV Sreedharan MR Pillai 2011 IntmiR: a complete catalogue of intronic miRNAs of human and mouse Bioinformation 5 458 459 21423893
43. D Wuttig B Baier S Fuessel M Meinhardt A Herr C Hoefling M Toma MO Grimm A Meye A Rolle MP Wirth 2009 Gene signatures of pulmonary metastases of renal cell carcinoma reflect the disease-free interval and the number of metastases per patient Int J Cancer 125 474 482 19391132 10.1002/ijc.24353 1:CAS:528:DC%2BD1MXms1amurg%3D
44. DS Finley AJ Pantuck AS Belldegrun 2011 Tumor biology and prognostic factors in renal cell carcinoma Oncologist 16 Suppl 2 4 13 21346035 10.1634/theoncologist.2011-S2-04
45. AP Noon N Vlatkovic R Polanski M Maguire H Shawki K Parsons MT Boyd 2010 p53 and MDM2 in renal cell carcinoma: biomarkers for disease progression and future therapeutic targets? Cancer 116 780 790 20052733 10.1002/cncr.24841 1:CAS:528:DC%2BC3cXivFWqu7o%3D
46. YK Shi YP Yu GC Tseng JH Luo 2010 Inhibition of prostate cancer growth and metastasis using small interference RNA specific for minichromosome complex maintenance component 7 Cancer Gene Ther 17 694 699 20539323 10.1038/cgt.2010.25 1:CAS:528:DC%2BC3cXntlSjsrw%3D
47. KA Honeycutt Z Chen MI Koster M Miers J Nuchtern J Hicks DR Roop JM Shohet 2006 Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis Oncogene 25 4027 4032 16518415 10.1038/sj.onc.1209435 1:CAS:528:DC%2BD28XmsFWgtLk%3D (Pubitemid 44024865)
48. B Ren G Yu GC Tseng K Cieply T Gavel J Nelson G Michalopoulos YP Yu JH Luo 2006 MCM7 amplification and overexpression are associated with prostate cancer progression Oncogene 25 1090 1098 16247466 10.1038/sj.onc.1209134 1:CAS:528:DC%2BD28XhsVeiurk%3D (Pubitemid 43277016)
49. K Yoshida I Inoue 2003 Conditional expression of MCM7 increases tumor growth without altering DNA replication activity FEBS Lett 553 213 217 14550576 10.1016/S0014-5793(03)01018-4 1:CAS:528:DC%2BD3sXnvFWht7w%3D (Pubitemid 37206354)
50. ML Yeung J Yasunaga Y Bennasser N Dusetti D Harris N Ahmad M Matsuoka KT Jeang 2008 Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1 Cancer Res 68 8976 8985 18974142 10.1158/0008-5472.CAN-08-0769 1:CAS:528:DC%2BD1cXhtlSkurzJ
51. T Luedde 2010 MicroRNA-151 and its hosting gene FAK (focal adhesion kinase) regulate tumor cell migration and spreading of hepatocellular carcinoma Hepatology 52 1164 1166 20812359 10.1002/hep.23854
52. MS Duxbury H Ito MJ Zinner SW Ashley EE Whang 2004 Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells Surgery 135 555 562 15118593 10.1016/j.surg.2003.10.017 1:STN:280:DC%2BD2c3itVGjsQ%3D%3D (Pubitemid 38586530)
53. T Miyazaki H Kato M Nakajima M Sohda Y Fukai N Masuda R Manda M Fukuchi K Tsukada H Kuwano 2003 FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma Br J Cancer 89 140 145 12838315 10.1038/sj.bjc.6601050 1:CAS:528:DC%2BD3sXltVWmsbw%3D (Pubitemid 36903212)
54. TM Weiner ET Liu RJ Craven WG Cance 1993 Expression of focal adhesion kinase gene and invasive cancer Lancet 342 1024 1025 8105266 10.1016/0140-6736(93)92881-S 1:STN:280:DyaK2c%2FhvVajug%3D%3D (Pubitemid 23314806)
55. CC Schimanski K Frerichs F Rahman M Berger H Lang PR Galle M Moehler I Gockel 2009 High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells World J Gastroenterol 15 2089 2096 19418581 10.3748/wjg.15.2089 1:CAS:528:DC%2BD1MXpsF2rsr8%3D
56. MF De Souza Setubal Destro CC Bitu KG Zecchin E Graner MA Lopes LP Kowalski RD Coletta 2010 Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis Int J Oncol 36 141 149 19956843
57. L Ma J Teruya-Feldstein RA Weinberg 2007 Tumour invasion and metastasis initiated by microRNA-10b in breast cancer Nature 449 682 688 17898713 10.1038/nature06174 1:CAS:528:DC%2BD2sXhtFChurfF (Pubitemid 47552092)
58. YJ Miyazaki J Hamada M Tada K Furuuchi Y Takahashi S Kondo H Katoh T Moriuchi 2002 HOXD3 enhances motility and invasiveness through the TGF-beta-dependent and -independent pathways in A549 cells Oncogene 21 798 808 11850808 10.1038/sj.onc.1205126 1:CAS:528:DC%2BD38Xht1Srurk%3D (Pubitemid 34146292)
59. C Guo JF Sah L Beard JK Willson SD Markowitz K Guda 2008 The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers Gene Chromosome Cancer 47 939 946 10.1002/gcc.20596 1:CAS:528:DC%2BD1cXhtFKms7vF
60. Y Saito JM Friedman Y Chihara G Egger JC Chuang G Liang 2009 Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells Biochem Biophys Res Commun 379 726 731 19116145 10.1016/j.bbrc.2008.12.098 1:CAS:528:DC%2BD1MXhtFemt7w%3D
61. TS Wong XB Liu BY Wong RW Ng AP Yuen WI Wei 2008 Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue Clin Cancer Res 14 2588 2592 18451220 10.1158/1078-0432.CCR-07-0666 1:CAS:528: DC%2BD1cXlsV2qsb4%3D
62. T Aikawa CA Whipple ME Lopez J Gunn A Young AD Lander M Korc 2008 Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells J Clin Invest 118 89 99 18064304 10.1172/JCI32412 1:CAS:528:DC%2BD1cXksFOmtQ%3D%3D