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Volumn 116, Issue 4, 2010, Pages 780-790

p53 and MDM2 in renal cell carcinoma: Biomarkers for disease progression and future therapeutic targets?

Author keywords

Murine double minute 2; p53; Renal cancer; Renal cell carcinoma

Indexed keywords

MUTANT PROTEIN; PROTEIN MDM2; PROTEIN P53;

EID: 76249112073     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.24841     Document Type: Review
Times cited : (95)

References (82)
  • 1
    • 76249101760 scopus 로고    scopus 로고
    • SEER Cancer Statistics Review, 1975-2006. Bethesda, Md: National Cancer Institute
    • Horner MJ, Ries LAG, Krapcho M, et al, eds, Available at:, Accessed on June 15, 2009
    • Horner MJ, Ries LAG, Krapcho M, et al, eds. SEER Cancer Statistics Review, 1975-2006. Bethesda, Md: National Cancer Institute. Based on the November 2008 SEER data submission; posted to the SEER website, 2009. Available at: http://info.cancerresearch.uk.org/cancerstats/types/kidney/incidence/. Accessed on June 15, 2009.
    • (2009) Based on the November 2008 SEER data submission; posted to the SEER website
  • 2
    • 84880324406 scopus 로고    scopus 로고
    • Cancer Research UK, London, United Kingdom: Cancer Research UK;
    • Cancer Research UK. UK Kidney Cancer Incidence Statistics, 2009. London, United Kingdom: Cancer Research UK; 2009.
    • (2009) UK Kidney Cancer Incidence Statistics, 2009
  • 3
  • 4
    • 33645763970 scopus 로고    scopus 로고
    • WHO classification of the renal tumors of the adults
    • Lopez-Beltran A, Scarpelli M, Montironi R, Kirkali Z. 2004 WHO classification of the renal tumors of the adults. Eur Urol. 2006;49:798-805.
    • (2004) Eur Urol , vol.2006 , Issue.49 , pp. 798-805
    • Lopez-Beltran, A.1    Scarpelli, M.2    Montironi, R.3    Kirkali, Z.4
  • 5
    • 0028108985 scopus 로고
    • Database of p53 gene somatic mutations in human tumors and cell lines
    • Hollstein M, Rice K, Greenblatt MS, et al. Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res. 1994;22:3551-3555.
    • (1994) Nucleic Acids Res , vol.22 , pp. 3551-3555
    • Hollstein, M.1    Rice, K.2    Greenblatt, M.S.3
  • 6
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    • Malkin D, Li FP, Strong LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990;250:1233-1238.
    • (1990) Science , vol.250 , pp. 1233-1238
    • Malkin, D.1    Li, F.P.2    Strong, L.C.3
  • 7
    • 0028823020 scopus 로고    scopus 로고
    • Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature. 1995;378:203-206.
    • Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature. 1995;378:203-206.
  • 8
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 1993;7:1126-1132.
    • (1993) Genes Dev , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 9
    • 0030860911 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: A dual mechanism
    • Thut CJ, Goodrich JA, Tjian R. Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes Dev. 1997;11:1974-1986.
    • (1997) Genes Dev , vol.11 , pp. 1974-1986
    • Thut, C.J.1    Goodrich, J.A.2    Tjian, R.3
  • 10
  • 11
    • 0034708458 scopus 로고    scopus 로고
    • Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
    • Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem. 2000;275: 8945-8951.
    • (2000) J Biol Chem , vol.275 , pp. 8945-8951
    • Fang, S.1    Jensen, J.P.2    Ludwig, R.L.3    Vousden, K.H.4    Weissman, A.M.5
  • 12
    • 33749188859 scopus 로고    scopus 로고
    • MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation
    • Yang JY, Zong CS, Xia W, et al. MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation. Mol Cell Biol. 2006;26:7269-7282.
    • (2006) Mol Cell Biol , vol.26 , pp. 7269-7282
    • Yang, J.Y.1    Zong, C.S.2    Xia, W.3
  • 13
    • 0036157247 scopus 로고    scopus 로고
    • Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods
    • Lu ML, Wikman F, Orntoft TF, et al. Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods. Clin Cancer Res. 2002;8:171-179.
    • (2002) Clin Cancer Res , vol.8 , pp. 171-179
    • Lu, M.L.1    Wikman, F.2    Orntoft, T.F.3
  • 14
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • Canman CE, Lim DS, Cimprich KA, et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 1998;281:1677-1679.
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1    Lim, D.S.2    Cimprich, K.A.3
  • 15
    • 4944255743 scopus 로고    scopus 로고
    • Post-translational modification of p53 in tumorigenesis
    • Bode AM, Dong Z. Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer. 2004;4:793-805.
    • (2004) Nat Rev Cancer , vol.4 , pp. 793-805
    • Bode, A.M.1    Dong, Z.2
  • 16
    • 27644590943 scopus 로고    scopus 로고
    • Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry
    • Nenutil R, Smardova J, Pavlova S, et al. Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry. J Pathol. 2005; 207:251-259.
    • (2005) J Pathol , vol.207 , pp. 251-259
    • Nenutil, R.1    Smardova, J.2    Pavlova, S.3
  • 17
    • 15244362062 scopus 로고    scopus 로고
    • P53 abnormalities and outcomes in colorectal cancer: A systematic review
    • Munro AJ, Lain S, Lane DP. P53 abnormalities and outcomes in colorectal cancer: a systematic review. Br J Cancer. 2005;92:434-444.
    • (2005) Br J Cancer , vol.92 , pp. 434-444
    • Munro, A.J.1    Lain, S.2    Lane, D.P.3
  • 18
    • 2342461756 scopus 로고    scopus 로고
    • To die or not to die: How does p53 decide?
    • Slee EA, O'Connor DJ, Lu X. To die or not to die: how does p53 decide? Oncogene. 2004;23:2809-2818.
    • (2004) Oncogene , vol.23 , pp. 2809-2818
    • Slee, E.A.1    O'Connor, D.J.2    Lu, X.3
  • 19
    • 0030460978 scopus 로고    scopus 로고
    • The p53 response to ionising radiation in adult and developing murine tissues
    • MacCallum DE, Hupp TR, Midgley CA, et al. The p53 response to ionising radiation in adult and developing murine tissues. Oncogene. 1996;13:2575-2587.
    • (1996) Oncogene , vol.13 , pp. 2575-2587
    • MacCallum, D.E.1    Hupp, T.R.2    Midgley, C.A.3
  • 20
    • 0842332406 scopus 로고    scopus 로고
    • Dynamics of the p53-Mdm2 feedback loop in individual cells
    • Lahav G, Rosenfeld N, Sigal A, et al. Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet. 2004;36:147-150.
    • (2004) Nat Genet , vol.36 , pp. 147-150
    • Lahav, G.1    Rosenfeld, N.2    Sigal, A.3
  • 23
    • 39049165830 scopus 로고    scopus 로고
    • Regulation of angiogenic factors by HDM2 in renal cell carcinoma
    • Carroll VA, Ashcroft M. Regulation of angiogenic factors by HDM2 in renal cell carcinoma. Cancer Res. 2008; 68:545-552.
    • (2008) Cancer Res , vol.68 , pp. 545-552
    • Carroll, V.A.1    Ashcroft, M.2
  • 24
    • 64549154074 scopus 로고    scopus 로고
    • Molecular signatures of localized clear cell renal cell carcinoma to predict disease-free survival after nephrectomy
    • Klatte T, Seligson DB, LaRochelle J, et al. Molecular signatures of localized clear cell renal cell carcinoma to predict disease-free survival after nephrectomy. Cancer Epidemiol Biomarkers Prev. 2009;18:894-900.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 894-900
    • Klatte, T.1    Seligson, D.B.2    LaRochelle, J.3
  • 25
    • 45449099580 scopus 로고    scopus 로고
    • Differential expression of prognostic markers in histological subtypes of papillary renal cell carcinoma
    • Perret AG, Clemencon A, Li G, Tostain J, Peoc'h M. Differential expression of prognostic markers in histological subtypes of papillary renal cell carcinoma. BJU Int. 2008;102:183-187.
    • (2008) BJU Int , vol.102 , pp. 183-187
    • Perret, A.G.1    Clemencon, A.2    Li, G.3    Tostain, J.4    Peoc'h, M.5
  • 26
    • 34247637684 scopus 로고    scopus 로고
    • Immunohistochemical analysis with multiple antibodies in search of prognostic markers for clear cell renal cell carcinoma
    • Phuoc NB, Ehara H, Gotoh T, et al. Immunohistochemical analysis with multiple antibodies in search of prognostic markers for clear cell renal cell carcinoma. Urology. 2007; 69:843-848.
    • (2007) Urology , vol.69 , pp. 843-848
    • Phuoc, N.B.1    Ehara, H.2    Gotoh, T.3
  • 27
    • 33750726054 scopus 로고    scopus 로고
    • The association of immunoreactive p53 and Ki-67 with T-stage, grade, occurrence of metastases and survival in renal cell carcinoma
    • Kankuri M, Soderstrom KO, Pelliniemi TT, Vahlberg T, Pyrhonen S, Salminen E. The association of immunoreactive p53 and Ki-67 with T-stage, grade, occurrence of metastases and survival in renal cell carcinoma. Anticancer Res. 2006;26(5B):3825-3833.
    • (2006) Anticancer Res , vol.26 , Issue.5 B , pp. 3825-3833
    • Kankuri, M.1    Soderstrom, K.O.2    Pelliniemi, T.T.3    Vahlberg, T.4    Pyrhonen, S.5    Salminen, E.6
  • 28
    • 25844478044 scopus 로고    scopus 로고
    • Prognostic significance of ploidy, MIB-1 proliferation marker, and p53 in renal cell carcinoma
    • Kramer BA, Gao X, Davis M, Hall M, Holzbeierlein J, Tawfik O. Prognostic significance of ploidy, MIB-1 proliferation marker, and p53 in renal cell carcinoma. J Am Coll Surg. 2005;201:565-570.
    • (2005) J Am Coll Surg , vol.201 , pp. 565-570
    • Kramer, B.A.1    Gao, X.2    Davis, M.3    Hall, M.4    Holzbeierlein, J.5    Tawfik, O.6
  • 29
    • 14144249315 scopus 로고    scopus 로고
    • The pT1a and pT1b category subdivision in renal cell carcinoma: Is it reflected by differences in tumour biology?
    • Langner C, Ratschek M, Rehak P, Tsybrovskyy O, Zigeuner R. The pT1a and pT1b category subdivision in renal cell carcinoma: is it reflected by differences in tumour biology? BJU Int. 2005;95:310-314.
    • (2005) BJU Int , vol.95 , pp. 310-314
    • Langner, C.1    Ratschek, M.2    Rehak, P.3    Tsybrovskyy, O.4    Zigeuner, R.5
  • 30
    • 14944358654 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and p53 expression as prognostic indicators in conventional renal cell carcinoma
    • Cho DS, Joo HJ, Oh DK, et al. Cyclooxygenase-2 and p53 expression as prognostic indicators in conventional renal cell carcinoma. Yonsei Med J. 2005;46:133-140.
    • (2005) Yonsei Med J , vol.46 , pp. 133-140
    • Cho, D.S.1    Joo, H.J.2    Oh, D.K.3
  • 31
    • 13744253120 scopus 로고    scopus 로고
    • p53 is an independent predictor of tumor recurrence and progression after nephrectomy in patients with localized renal cell carcinoma
    • Shvarts O, Seligson D, Lam J, et al. p53 is an independent predictor of tumor recurrence and progression after nephrectomy in patients with localized renal cell carcinoma. J Urol. 2005;173:725-728.
    • (2005) J Urol , vol.173 , pp. 725-728
    • Shvarts, O.1    Seligson, D.2    Lam, J.3
  • 32
    • 14944365551 scopus 로고    scopus 로고
    • Expression of p53 oncoprotein and bcl-2 in renal cell carcinoma
    • Uzunlar AK, Sahin H, Yilmaz F, Ozekinci S. Expression of p53 oncoprotein and bcl-2 in renal cell carcinoma. Saudi Med J. 2005;26:37-41.
    • (2005) Saudi Med J , vol.26 , pp. 37-41
    • Uzunlar, A.K.1    Sahin, H.2    Yilmaz, F.3    Ozekinci, S.4
  • 33
    • 1842789760 scopus 로고    scopus 로고
    • Value of p53 as a prognostic marker in histologic subtypes of renal cell carcinoma: A systematic analysis of primary and metastatic tumor tissue
    • Zigeuner R, Ratschek M, Rehak P, Schips L, Langner C. Value of p53 as a prognostic marker in histologic subtypes of renal cell carcinoma: a systematic analysis of primary and metastatic tumor tissue. Urology. 2004;63: 651-655.
    • (2004) Urology , vol.63 , pp. 651-655
    • Zigeuner, R.1    Ratschek, M.2    Rehak, P.3    Schips, L.4    Langner, C.5
  • 34
    • 4143060340 scopus 로고    scopus 로고
    • Using protein expressions to predict survival in clear cell renal carcinoma
    • Kim HL, Seligson D, Liu X, et al. Using protein expressions to predict survival in clear cell renal carcinoma. Clin Cancer Res. 2004;10:5464-5471.
    • (2004) Clin Cancer Res , vol.10 , pp. 5464-5471
    • Kim, H.L.1    Seligson, D.2    Liu, X.3
  • 35
    • 0036129145 scopus 로고    scopus 로고
    • Clinical significance of p53, mdm2, and bcl-2 proteins in renal cell carcinoma
    • Uchida T, Gao JP, Wang C, et al. Clinical significance of p53, mdm2, and bcl-2 proteins in renal cell carcinoma. Urology. 2002;59:615-620.
    • (2002) Urology , vol.59 , pp. 615-620
    • Uchida, T.1    Gao, J.P.2    Wang, C.3
  • 36
    • 0035141999 scopus 로고    scopus 로고
    • p53 immunoreactivity correlates with Ki-67 and bcl-2 expression in renal cell carcinoma
    • Olumi AF, Weidner N, Presti JC. p53 immunoreactivity correlates with Ki-67 and bcl-2 expression in renal cell carcinoma. Urol Oncol. 2001;6:63-67.
    • (2001) Urol Oncol , vol.6 , pp. 63-67
    • Olumi, A.F.1    Weidner, N.2    Presti, J.C.3
  • 37
    • 0035091293 scopus 로고    scopus 로고
    • p53 expression in correlation to clinical outcome in patients with renal cell carcinoma
    • Ljungberg B, Bozoky B, Kovacs G, et al. p53 expression in correlation to clinical outcome in patients with renal cell carcinoma. Scand J Urol Nephrol. 2001;35:15-20.
    • (2001) Scand J Urol Nephrol , vol.35 , pp. 15-20
    • Ljungberg, B.1    Bozoky, B.2    Kovacs, G.3
  • 38
    • 0035104991 scopus 로고    scopus 로고
    • P53 mutations and other prognostic factors of renal cell carcinoma
    • Girgin C, Tarhan H, Hekimgil M, Sezer A, Gurel G. P53 mutations and other prognostic factors of renal cell carcinoma. Urol Int. 2001;66:78-83.
    • (2001) Urol Int , vol.66 , pp. 78-83
    • Girgin, C.1    Tarhan, H.2    Hekimgil, M.3    Sezer, A.4    Gurel, G.5
  • 39
    • 0034026143 scopus 로고    scopus 로고
    • mdm2 expression as a prognostic indicator in clear cell renal cell carcinoma: Comparison with p53 overexpression and clinicopathological parameters
    • Haitel A, Wiener HG, Baethge U, Marberger M, Susani M. mdm2 expression as a prognostic indicator in clear cell renal cell carcinoma: comparison with p53 overexpression and clinicopathological parameters. Clin Cancer Res. 2000; 6:1840-1844.
    • (2000) Clin Cancer Res , vol.6 , pp. 1840-1844
    • Haitel, A.1    Wiener, H.G.2    Baethge, U.3    Marberger, M.4    Susani, M.5
  • 40
    • 0034114740 scopus 로고    scopus 로고
    • Value of immunohistochemical Ki-67 and p53 determinations as predictive factors of outcome in renal cell carcinoma
    • Rioux-Leclercq N, Turlin B, Bansard J, et al. Value of immunohistochemical Ki-67 and p53 determinations as predictive factors of outcome in renal cell carcinoma. Urology. 2000;55:501-505.
    • (2000) Urology , vol.55 , pp. 501-505
    • Rioux-Leclercq, N.1    Turlin, B.2    Bansard, J.3
  • 41
    • 0033015616 scopus 로고    scopus 로고
    • Expression of bcl-2, p53 oncoprotein, and proliferating cell nuclear antigen in renal cell carcinoma
    • Sejima T, Miyagawa I. Expression of bcl-2, p53 oncoprotein, and proliferating cell nuclear antigen in renal cell carcinoma. Eur Urol. 1999;35:242-248.
    • (1999) Eur Urol , vol.35 , pp. 242-248
    • Sejima, T.1    Miyagawa, I.2
  • 42
    • 0032101601 scopus 로고    scopus 로고
    • P53, bcl-2, and Bax expression in renal cell carcinoma
    • Vasavada SP, Novick AC, Williams BR. P53, bcl-2, and Bax expression in renal cell carcinoma. Urology. 1998; 51: 1057-1061.
    • (1998) Urology , vol.51 , pp. 1057-1061
    • Vasavada, S.P.1    Novick, A.C.2    Williams, B.R.3
  • 43
    • 0031435603 scopus 로고    scopus 로고
    • Nuclear p53 overexpression in bladder, prostate, and renal carcinomas
    • Sinik Z, Alkibay T, Ataoglu O, et al. Nuclear p53 overexpression in bladder, prostate, and renal carcinomas. Int J Urol. 1997;4:546-551.
    • (1997) Int J Urol , vol.4 , pp. 546-551
    • Sinik, Z.1    Alkibay, T.2    Ataoglu, O.3
  • 44
    • 0030877698 scopus 로고    scopus 로고
    • Value of p53 expression, cellular proliferation, and DNA content as prognostic indicators in renal cell carcinoma
    • Papadopoulos I, Rudolph P, Weichert-Jacobsen K. Value of p53 expression, cellular proliferation, and DNA content as prognostic indicators in renal cell carcinoma. Eur Urol. 1997;32:110-117.
    • (1997) Eur Urol , vol.32 , pp. 110-117
    • Papadopoulos, I.1    Rudolph, P.2    Weichert-Jacobsen, K.3
  • 45
    • 0030755105 scopus 로고    scopus 로고
    • p53 and HER-2 alterations in renal cell carcinoma
    • Zhang XH, Takenaka I, Sato C, Sakamoto H. p53 and HER-2 alterations in renal cell carcinoma. Urology. 1997; 50:636-642.
    • (1997) Urology , vol.50 , pp. 636-642
    • Zhang, X.H.1    Takenaka, I.2    Sato, C.3    Sakamoto, H.4
  • 46
    • 0030695994 scopus 로고    scopus 로고
    • Appraisal of intratumoral microvessel density, MIB-1 score, DNA content, and p53 protein expression as prognostic indicators in patients with locally confined renal cell carcinoma
    • Gelb AB, Sudilovsky D, Wu CD, Weiss LM, Medeiros LJ. Appraisal of intratumoral microvessel density, MIB-1 score, DNA content, and p53 protein expression as prognostic indicators in patients with locally confined renal cell carcinoma. Cancer. 1997;80:1768-1775.
    • (1997) Cancer , vol.80 , pp. 1768-1775
    • Gelb, A.B.1    Sudilovsky, D.2    Wu, C.D.3    Weiss, L.M.4    Medeiros, L.J.5
  • 47
    • 0031034067 scopus 로고    scopus 로고
    • Clinical significance of immunohistochemically detectable p53 protein in renal cell carcinoma
    • Shiina H, Igawa M, Urakami S, Shirakawa H, Ishibe T, Kawanishi M. Clinical significance of immunohistochemically detectable p53 protein in renal cell carcinoma. Eur Urol. 1997;31:73-80.
    • (1997) Eur Urol , vol.31 , pp. 73-80
    • Shiina, H.1    Igawa, M.2    Urakami, S.3    Shirakawa, H.4    Ishibe, T.5    Kawanishi, M.6
  • 48
    • 0030893002 scopus 로고    scopus 로고
    • p53 protein expression but not mdm-2 protein expression is associated with rapid tumor cell proliferation and prognosis in renal cell carcinoma
    • Moch H, Sauter G, Gasser TC, et al. p53 protein expression but not mdm-2 protein expression is associated with rapid tumor cell proliferation and prognosis in renal cell carcinoma. Urol Res. 1997;25(suppl 1):S25-S30.
    • (1997) Urol Res , vol.25 , Issue.SUPPL. 1
    • Moch, H.1    Sauter, G.2    Gasser, T.C.3
  • 49
    • 0030513772 scopus 로고    scopus 로고
    • Expression of p53 and bcl-2 in primary locally confined renal cell carcinomas: No evidence for prognostic significance
    • Hofmockel G, Wittmann A, Dammrich J, Bassukas ID. Expression of p53 and bcl-2 in primary locally confined renal cell carcinomas: no evidence for prognostic significance. Anticancer Res. 1996;16(6B):3807-3811.
    • (1996) Anticancer Res , vol.16 , Issue.6 B , pp. 3807-3811
    • Hofmockel, G.1    Wittmann, A.2    Dammrich, J.3    Bassukas, I.D.4
  • 50
    • 0029116583 scopus 로고
    • Elevated content of p53 protein in the absence of p53 gene mutations as a possible prognostic marker for human renal cell tumors
    • Chemeris G, Loktinov A, Rempel A, Schwarz M, Bannasch P. Elevated content of p53 protein in the absence of p53 gene mutations as a possible prognostic marker for human renal cell tumors. Virchows Arch. 1995;426:563-569.
    • (1995) Virchows Arch , vol.426 , pp. 563-569
    • Chemeris, G.1    Loktinov, A.2    Rempel, A.3    Schwarz, M.4    Bannasch, P.5
  • 51
    • 0028344419 scopus 로고
    • Expression of proliferating cell nuclear antigen (PC10), p53 protein and c-erbB-2 in renal adenocarcinoma
    • Lipponen P, Eskelinen M, Hietala K, Syrjanen K, Gambetta RA. Expression of proliferating cell nuclear antigen (PC10), p53 protein and c-erbB-2 in renal adenocarcinoma. Int J Cancer. 1994;57:275-280.
    • (1994) Int J Cancer , vol.57 , pp. 275-280
    • Lipponen, P.1    Eskelinen, M.2    Hietala, K.3    Syrjanen, K.4    Gambetta, R.A.5
  • 52
    • 0028075573 scopus 로고
    • Proliferating cell nuclear antigen but not p53 or human papillomavirus DNA correlates with advanced clinical stage in renal cell carcinoma
    • Kamel D, Turpeenniemi-Hujanen T, Vahakangas K, Paakko P, Soini Y. Proliferating cell nuclear antigen but not p53 or human papillomavirus DNA correlates with advanced clinical stage in renal cell carcinoma. Histopathology. 1994;25:339-347.
    • (1994) Histopathology , vol.25 , pp. 339-347
    • Kamel, D.1    Turpeenniemi-Hujanen, T.2    Vahakangas, K.3    Paakko, P.4    Soini, Y.5
  • 53
    • 0028224804 scopus 로고
    • Prognostic factors in renal-cell carcinoma: Immunohistochemical detection of p53 protein versus clinico-pathological parameters
    • Bot FJ, Godschalk JC, Krishnadath KK, van der Kwast TH, Bosman FT. Prognostic factors in renal-cell carcinoma: immunohistochemical detection of p53 protein versus clinico-pathological parameters. Int J Cancer. 1994; 57:634-637.
    • (1994) Int J Cancer , vol.57 , pp. 634-637
    • Bot, F.J.1    Godschalk, J.C.2    Krishnadath, K.K.3    van der Kwast, T.H.4    Bosman, F.T.5
  • 54
    • 0027942884 scopus 로고
    • Association of immunohistochemical staining for p53 with metastatic progression and poor survival in patients with renal cell carcinoma
    • Uhlman DL, Nguyen PL, Manivel JC, et al. Association of immunohistochemical staining for p53 with metastatic progression and poor survival in patients with renal cell carcinoma. J Natl Cancer Inst. 1994;86:1470-1475.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1470-1475
    • Uhlman, D.L.1    Nguyen, P.L.2    Manivel, J.C.3
  • 55
    • 77953440105 scopus 로고    scopus 로고
    • Boyd MT, Vlatkovic N. p53: a molecular marker for the detection of cancer. Expert Opin Med Diagn. 2008;2:1013-1024.
    • Boyd MT, Vlatkovic N. p53: a molecular marker for the detection of cancer. Expert Opin Med Diagn. 2008;2:1013-1024.
  • 56
    • 38149054906 scopus 로고    scopus 로고
    • Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins?
    • Anczukow O, Ware MD, Buisson M, et al. Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins? Hum Mutat. 2008;29:65-73.
    • (2008) Hum Mutat , vol.29 , pp. 65-73
    • Anczukow, O.1    Ware, M.D.2    Buisson, M.3
  • 57
    • 37349055876 scopus 로고    scopus 로고
    • TP53 mutations and survival in squamous-cell carcinoma of the head and neck
    • Poeta ML, Manola J, Goldwasser MA, et al. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 2007;357:2552-2561.
    • (2007) N Engl J Med , vol.357 , pp. 2552-2561
    • Poeta, M.L.1    Manola, J.2    Goldwasser, M.A.3
  • 58
    • 33846490110 scopus 로고    scopus 로고
    • Mutations in BHD and TP53 genes, but not in HNF1beta gene, in a large series of sporadic chromophobe renal cell carcinoma
    • Gad S, Lefevre SH, Khoo SK, et al. Mutations in BHD and TP53 genes, but not in HNF1beta gene, in a large series of sporadic chromophobe renal cell carcinoma. Br J Cancer. 2007;96:336-340.
    • (2007) Br J Cancer , vol.96 , pp. 336-340
    • Gad, S.1    Lefevre, S.H.2    Khoo, S.K.3
  • 59
    • 0033094077 scopus 로고    scopus 로고
    • Infrequent alteration of p53 pathway in metastatic renal cell carcinoma
    • Kawasaki T, Bilim V, Takahashi K, Tomita Y. Infrequent alteration of p53 pathway in metastatic renal cell carcinoma. Oncol Rep. 1999;6:329-333.
    • (1999) Oncol Rep , vol.6 , pp. 329-333
    • Kawasaki, T.1    Bilim, V.2    Takahashi, K.3    Tomita, Y.4
  • 60
    • 0031038176 scopus 로고    scopus 로고
    • Mutation of the p53 tumour suppressor gene occurs preferentially in the chromophobe type of renal cell tumour
    • Contractor H, Zariwala M, Bugert P, Zeisler J, Kovacs G. Mutation of the p53 tumour suppressor gene occurs preferentially in the chromophobe type of renal cell tumour. J Pathol. 1997;181:136-139.
    • (1997) J Pathol , vol.181 , pp. 136-139
    • Contractor, H.1    Zariwala, M.2    Bugert, P.3    Zeisler, J.4    Kovacs, G.5
  • 61
    • 0031938641 scopus 로고    scopus 로고
    • A novel p53 mutation hotspot at codon 132 (AAG→AGG) in human renal cancer
    • Dahiya R, Deng G, Selph C, Carroll P, Presti J Jr. A novel p53 mutation hotspot at codon 132 (AAG→AGG) in human renal cancer. Biochem Mol Biol Int. 1998;44:407-415.
    • (1998) Biochem Mol Biol Int , vol.44 , pp. 407-415
    • Dahiya, R.1    Deng, G.2    Selph, C.3    Carroll, P.4    Presti Jr, J.5
  • 62
    • 0029902408 scopus 로고    scopus 로고
    • Chromosomal findings and p53-mutation analysis in chromophilic renal-cell carcinomas
    • Dijkhuizen T, Van den Berg E, Van den Berg A, et al. Chromosomal findings and p53-mutation analysis in chromophilic renal-cell carcinomas. Int J Cancer. 1996;68:47-50.
    • (1996) Int J Cancer , vol.68 , pp. 47-50
    • Dijkhuizen, T.1    Van den Berg, E.2    Van den Berg, A.3
  • 63
    • 0028898538 scopus 로고
    • Mutations of the p53 gene and p53 protein overexpression are associated with sarcomatoid transformation in renal cell carcinomas
    • Oda H, Nakatsuru Y, Ishikawa T. Mutations of the p53 gene and p53 protein overexpression are associated with sarcomatoid transformation in renal cell carcinomas. Cancer Res. 1995;55:658-662.
    • (1995) Cancer Res , vol.55 , pp. 658-662
    • Oda, H.1    Nakatsuru, Y.2    Ishikawa, T.3
  • 64
    • 0029588556 scopus 로고
    • Detection of p53 gene alteration in renal-cell cancer by micropreparation techniques of tumor specimens
    • Kuczyk MA, Serth J, Bokemeyer C, et al. Detection of p53 gene alteration in renal-cell cancer by micropreparation techniques of tumor specimens. Int J Cancer. 1995;64:399-406.
    • (1995) Int J Cancer , vol.64 , pp. 399-406
    • Kuczyk, M.A.1    Serth, J.2    Bokemeyer, C.3
  • 65
    • 0027998416 scopus 로고
    • Genomic instability of microsatellite repeats and mutations of H-, K-, and N-ras, and p53 genes in renal cell carcinoma
    • Uchida T, Wada C, Wang C, Egawa S, Ohtani H, Koshiba K. Genomic instability of microsatellite repeats and mutations of H-, K-, and N-ras, and p53 genes in renal cell carcinoma. Cancer Res. 1994;54:3682-3685.
    • (1994) Cancer Res , vol.54 , pp. 3682-3685
    • Uchida, T.1    Wada, C.2    Wang, C.3    Egawa, S.4    Ohtani, H.5    Koshiba, K.6
  • 66
    • 0028276903 scopus 로고
    • Polymerase chain reaction-single strand conformation polymorphism analysis of the p53 gene in paraffin-embedded surgical material from human renal cell carcinomas
    • Kikuchi Y, Kishi T, Suzuki M, Furusato M, Aizawa S. Polymerase chain reaction-single strand conformation polymorphism analysis of the p53 gene in paraffin-embedded surgical material from human renal cell carcinomas. Virchows Arch. 1994;424:229-233.
    • (1994) Virchows Arch , vol.424 , pp. 229-233
    • Kikuchi, Y.1    Kishi, T.2    Suzuki, M.3    Furusato, M.4    Aizawa, S.5
  • 68
    • 0027282013 scopus 로고
    • Chromosome 17p deletions and p53 mutations in renal cell carcinoma
    • Reiter RE, Anglard P, Liu S, Gnarra JR, Linehan WM. Chromosome 17p deletions and p53 mutations in renal cell carcinoma. Cancer Res. 1993;53:3092-3097.
    • (1993) Cancer Res , vol.53 , pp. 3092-3097
    • Reiter, R.E.1    Anglard, P.2    Liu, S.3    Gnarra, J.R.4    Linehan, W.M.5
  • 69
    • 0026534279 scopus 로고
    • Infrequent mutation of p53 gene in human renal cell carcinoma detected by polymerase chain reaction single-strand conformation polymorphism analysis
    • Suzuki Y, Tamura G, Satodate R, Fujioka T. Infrequent mutation of p53 gene in human renal cell carcinoma detected by polymerase chain reaction single-strand conformation polymorphism analysis. Jpn J Cancer Res. 1992;83:233-235.
    • (1992) Jpn J Cancer Res , vol.83 , pp. 233-235
    • Suzuki, Y.1    Tamura, G.2    Satodate, R.3    Fujioka, T.4
  • 71
    • 34248379012 scopus 로고    scopus 로고
    • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
    • Petitjean A, Mathe E, Kato S, et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat. 2007;28:622-629.
    • (2007) Hum Mutat , vol.28 , pp. 622-629
    • Petitjean, A.1    Mathe, E.2    Kato, S.3
  • 72
    • 0035751937 scopus 로고    scopus 로고
    • Assessing TP53 status in human tumours to evaluate clinical outcome
    • Soussi T, Beroud C. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat Rev Cancer. 2001;1:233-240.
    • (2001) Nat Rev Cancer , vol.1 , pp. 233-240
    • Soussi, T.1    Beroud, C.2
  • 73
    • 0028098165 scopus 로고
    • Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
    • Cordon-Cardo C, Latres E, Drobnjak M, et al. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res. 1994;54:794-799.
    • (1994) Cancer Res , vol.54 , pp. 794-799
    • Cordon-Cardo, C.1    Latres, E.2    Drobnjak, M.3
  • 74
    • 34547220487 scopus 로고    scopus 로고
    • MDM2 SNP309 polymorphism as risk factor for susceptibility and poor prognosis in renal cell carcinoma
    • Hirata H, Hinoda Y, Kikuno N, et al. MDM2 SNP309 polymorphism as risk factor for susceptibility and poor prognosis in renal cell carcinoma. Clin Cancer Res. 2007;13:4123-4129.
    • (2007) Clin Cancer Res , vol.13 , pp. 4123-4129
    • Hirata, H.1    Hinoda, Y.2    Kikuno, N.3
  • 75
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004;303:844-848.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3
  • 76
    • 41649102468 scopus 로고    scopus 로고
    • Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
    • Shangary S, Qin D, McEachern D, et al. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci USA. 2008;105:3933-3938.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3933-3938
    • Shangary, S.1    Qin, D.2    McEachern, D.3
  • 77
    • 20444369867 scopus 로고    scopus 로고
    • Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
    • Yang Y, Ludwig RL, Jensen JP, et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell. 2005;7:547-559.
    • (2005) Cancer Cell , vol.7 , pp. 547-559
    • Yang, Y.1    Ludwig, R.L.2    Jensen, J.P.3
  • 79
    • 61349141840 scopus 로고    scopus 로고
    • 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways
    • Guo C, Gasparian AV, Zhuang Z, et al. 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways. Oncogene. 2009;28:1151-1161.
    • (2009) Oncogene , vol.28 , pp. 1151-1161
    • Guo, C.1    Gasparian, A.V.2    Zhuang, Z.3
  • 80
    • 60649103811 scopus 로고    scopus 로고
    • MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53
    • Enge M, Bao W, Hedstrom E, Jackson SP, Moumen A, Selivanova G. MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell. 2009;15:171-183.
    • (2009) Cancer Cell , vol.15 , pp. 171-183
    • Enge, M.1    Bao, W.2    Hedstrom, E.3    Jackson, S.P.4    Moumen, A.5    Selivanova, G.6
  • 81
    • 59549099511 scopus 로고    scopus 로고
    • Effect of renal cancer size on the prevalence of metastasis at diagnosis and mortality
    • discussion 1027
    • Nguyen MM, Gill IS. Effect of renal cancer size on the prevalence of metastasis at diagnosis and mortality. J Urol. 2009;181:1020-1027; discussion 1027.
    • (2009) J Urol , vol.181 , pp. 1020-1027
    • Nguyen, M.M.1    Gill, I.S.2
  • 82
    • 33645705685 scopus 로고    scopus 로고
    • Nonmetastatic renal-cell carcinoma: Is it really possible to define rational guidelines for post-treatment follow-up?
    • Rouviere O, Bouvier R, Negrier S, Badet L, Lyonnet D. Nonmetastatic renal-cell carcinoma: is it really possible to define rational guidelines for post-treatment follow-up? Nat Clin Pract Oncol. 2006;3:200-213.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 200-213
    • Rouviere, O.1    Bouvier, R.2    Negrier, S.3    Badet, L.4    Lyonnet, D.5


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