-
2
-
-
0345824731
-
P53-independent functions of MDM2
-
Ganguli G., Wasylyk B. P53-independent functions of MDM2. Mol. Cancer Res. 2003, 1:1027-1035.
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 1027-1035
-
-
Ganguli, G.1
Wasylyk, B.2
-
3
-
-
0029824669
-
Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer
-
Sigalas I., Calvert A.H., Anderson J.J., Neal D.E., Lunec J. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nat. Med. 1996, 2:912-917.
-
(1996)
Nat. Med.
, vol.2
, pp. 912-917
-
-
Sigalas, I.1
Calvert, A.H.2
Anderson, J.J.3
Neal, D.E.4
Lunec, J.5
-
4
-
-
14444281159
-
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53
-
Lundgren K., et al. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev. 1997, 11:714-725.
-
(1997)
Genes Dev.
, vol.11
, pp. 714-725
-
-
Lundgren, K.1
-
5
-
-
0032417695
-
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
-
Jones S.N., Hancock A.R., Vogel H., Donehower L.A., Bradley A. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc. Natl. Acad. Sci. USA 1998, 95:15608-15612.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15608-15612
-
-
Jones, S.N.1
Hancock, A.R.2
Vogel, H.3
Donehower, L.A.4
Bradley, A.5
-
6
-
-
34250378293
-
The RING finger domain of MDM2 is essential for MDM2-mediated TGF-beta resistance
-
Kannemeier C., Liao R., Sun P. The RING finger domain of MDM2 is essential for MDM2-mediated TGF-beta resistance. Mol. Biol. Cell 2007, 18:2367-2377.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 2367-2377
-
-
Kannemeier, C.1
Liao, R.2
Sun, P.3
-
7
-
-
44849096848
-
MDM2 regulates dihydrofolate reductase activity through monoubiquitination
-
Maguire M., Nield P.C., Devling T., Jenkins R.E., Park B.K., Polanski R., Vlatkovic N., Boyd M.T. MDM2 regulates dihydrofolate reductase activity through monoubiquitination. Cancer Res. 2008, 68:3232-3242.
-
(2008)
Cancer Res.
, vol.68
, pp. 3232-3242
-
-
Maguire, M.1
Nield, P.C.2
Devling, T.3
Jenkins, R.E.4
Park, B.K.5
Polanski, R.6
Vlatkovic, N.7
Boyd, M.T.8
-
8
-
-
67349166210
-
P53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
-
Wang S.P., et al. P53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nat. Cell Biol. 2009, 11:694-704.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 694-704
-
-
Wang, S.P.1
-
9
-
-
33749188859
-
MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation
-
Yang J.Y., et al. MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation. Mol. Cell. Biol. 2006, 26:7269-7282.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 7269-7282
-
-
Yang, J.Y.1
-
10
-
-
76249112073
-
P53 and MDM2 in renal cell carcinoma: biomarkers for disease progression and future therapeutic targets?
-
Noon A.P., Vlatkovic N., Polanski R., Maguire M., Shawki H., Parsons K., Boyd M.T. P53 and MDM2 in renal cell carcinoma: biomarkers for disease progression and future therapeutic targets?. Cancer 2010, 116:780-790.
-
(2010)
Cancer
, vol.116
, pp. 780-790
-
-
Noon, A.P.1
Vlatkovic, N.2
Polanski, R.3
Maguire, M.4
Shawki, H.5
Parsons, K.6
Boyd, M.T.7
-
11
-
-
0034644731
-
A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2
-
Boyd M.T., Vlatkovic N., Haines D.S. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J. Biol. Chem. 2000, 275:31883-31890.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 31883-31890
-
-
Boyd, M.T.1
Vlatkovic, N.2
Haines, D.S.3
-
13
-
-
0037069330
-
Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways
-
Martinez L.A., Naguibneva I., Lehrmann H., Vervisch A., Tchenio T., Lozano G., Harel-Bellan A. Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways. Proc. Natl. Acad. Sci. USA 2002, 99:14849-14854.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14849-14854
-
-
Martinez, L.A.1
Naguibneva, I.2
Lehrmann, H.3
Vervisch, A.4
Tchenio, T.5
Lozano, G.6
Harel-Bellan, A.7
-
14
-
-
23044508514
-
P53 regulation and function in renal cell carcinoma
-
Warburton H.E., Brady M., Vlatkovic N., Linehan W.M., Parsons K., Boyd M.T. P53 regulation and function in renal cell carcinoma. Cancer Res. 2005, 65:6498-6503.
-
(2005)
Cancer Res.
, vol.65
, pp. 6498-6503
-
-
Warburton, H.E.1
Brady, M.2
Vlatkovic, N.3
Linehan, W.M.4
Parsons, K.5
Boyd, M.T.6
-
15
-
-
33845987102
-
Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility
-
Thompson C.C., et al. Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. Gut 2007, 56:95-106.
-
(2007)
Gut
, vol.56
, pp. 95-106
-
-
Thompson, C.C.1
-
16
-
-
0034026143
-
Mdm2 expression as a prognostic indicator in clear cell renal cell carcinoma: comparison with p53 overexpression and clinicopathological parameters
-
Haitel A., Wiener H.G., Baethge U., Marberger M., Susani M. Mdm2 expression as a prognostic indicator in clear cell renal cell carcinoma: comparison with p53 overexpression and clinicopathological parameters. Clin. Cancer Res. 2000, 6:1840-1844.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 1840-1844
-
-
Haitel, A.1
Wiener, H.G.2
Baethge, U.3
Marberger, M.4
Susani, M.5
-
17
-
-
0030893002
-
P53 protein expression but not mdm-2 protein expression is associated with rapid tumor cell proliferation and prognosis in renal cell carcinoma
-
Moch H., et al. p53 protein expression but not mdm-2 protein expression is associated with rapid tumor cell proliferation and prognosis in renal cell carcinoma. Urol. Res. 1997, 25(Suppl. 1):S25-S30.
-
(1997)
Urol. Res.
, vol.25
, Issue.SUPPL. 1
-
-
Moch, H.1
-
18
-
-
33846477806
-
Targeted molecular therapy for renal cell carcinoma
-
Lane B.R., Rini B.I., Novick A.C., Campbell S.C. Targeted molecular therapy for renal cell carcinoma. Urology 2007, 69:3-10.
-
(2007)
Urology
, vol.69
, pp. 3-10
-
-
Lane, B.R.1
Rini, B.I.2
Novick, A.C.3
Campbell, S.C.4
-
19
-
-
0032080297
-
The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis
-
Brown D.R., Thomas C.A., Deb S.P. The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis. EMBO J. 1998, 17:2513-2525.
-
(1998)
EMBO J.
, vol.17
, pp. 2513-2525
-
-
Brown, D.R.1
Thomas, C.A.2
Deb, S.P.3
-
20
-
-
0034708458
-
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
-
Fang S., Jensen J.P., Ludwig R.L., Vousden K.H., Weissman A.M. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J. Biol. Chem. 2000, 275:8945-8951.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8945-8951
-
-
Fang, S.1
Jensen, J.P.2
Ludwig, R.L.3
Vousden, K.H.4
Weissman, A.M.5
-
21
-
-
0034624678
-
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
-
Honda R., Yasuda H. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 2000, 19:1473-1476.
-
(2000)
Oncogene
, vol.19
, pp. 1473-1476
-
-
Honda, R.1
Yasuda, H.2
-
22
-
-
3142570737
-
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
-
Xirodimas D.P., Saville M.K., Bourdon J.C., Hay R.T., Lane D.P. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 2004, 118:83-97.
-
(2004)
Cell
, vol.118
, pp. 83-97
-
-
Xirodimas, D.P.1
Saville, M.K.2
Bourdon, J.C.3
Hay, R.T.4
Lane, D.P.5
-
23
-
-
35148847384
-
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
-
Itahana K., et al. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 2007, 12:355-366.
-
(2007)
Cancer Cell
, vol.12
, pp. 355-366
-
-
Itahana, K.1
-
24
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev L.T., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004, 303:844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
-
25
-
-
33745154819
-
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction
-
Ding K., et al. Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. J. Med. Chem. 2006, 49:3432-3435.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 3432-3435
-
-
Ding, K.1
|