Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition

Cellular Signalling

Volumn 24, Issue 2, 2012, Pages 493-504

  Goltsov, Alexey ^a   Faratian, Dana ^b   Langdon, Simon P ^b   Mullen, Peter ^b   Harrison, David J ^b   Bown, James ^a  

^a UNIVERSITY OF ABERTAY DUNDEE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Anticancer drug resistance; Drug combination; Pertuzumab; PI3K PTEN AKT signalling network; RTK inhibitor; Sensitivity analysis

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASEIN KINASE II; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLYCOGEN SYNTHASE KINASE 3BETA; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SENSITIVITY; DRUG TARGETING; GENE REGULATORY NETWORK; HUMAN; HUMAN CELL; IC 50; MARKER GENE; MUTATIONAL ANALYSIS; PIK3CA GENE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION;

ALGORITHMS; ANTIBODIES, MONOCLONAL, HUMANIZED; BLOTTING, WESTERN; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; KINETICS; MODELS, THEORETICAL; MUTATION; OVARIAN NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION;

EID: 83555173299     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2011.09.030     Document Type: Article

References (50)

1. Chen W.W., Schoeberl B., Jasper P.J., Niepel M., Nielsen U.B., Lauffenburger D.A., Sorger P.K. Molecular Systems Biology 2009, 5:239.
2. Schoeberl B., Pace E.A., Fitzgerald J.B., Harms B.D., Xu L., Nie L., Linggi B., Kalra A., Paragas V., Bukhalid R., Grantcharova V., Kohli N., West K.A., Leszczyniecka M., Feldhaus M.J., Kudla A.J., Nielsen U.B. Science Signaling 2009, 2:ra31.
3. Wang C.C., Cirit M., Haugh J.M. Molecular Systems Biology 2009, 5:246.
4. Birtwistle M.R., Hatakeyama M., Yumoto N., Ogunnaike B.A., Hoek J.B., Kholodenko B.N. Molecular Systems Biology 2007, 3:144.
5. Lauffenburger D.A. Carcinogenesis 2010, 31:2.
6. Faratian D., Clyde R.G., Crawford J.W., Harrison D.J. Nature Reviews. Clinical Oncology 2009, 6:455.
7. Faratian D., Bown J.L., Smith V.A., Langdon S.P., Harrison D.J. Methods in Molecular Biology 2010, 662:245.
8. Klipp E., Wade R.C., Kummer U. Current Opinion in Biotechnology 2010, 21:511.
9. Shiraishi T., Matsuyama S., Kitano H. PLoS Computational Biology 2010, 6:e1000851.
10. Kitano H. Nature Reviews. Drug Discovery 2007, 6:202.
11. Faber A.C., Li D., Song Y.C., Liang M.C., Yeap B.Y., Bronson R.T., Lifshits E., Chen Z., Maira S., García-Echeverría C., Wong K.K., Engelmanad J.A. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:19503.
12. Yuan T.L., Cantley L.C. Oncogene 2008, 272:5497.
13. Amit I., Wides R., Yarden Y. Molecular Systems Biology 2007, 3:151.
14. Aksamitiene E., Kholodenko B.N., Kolch W., Hoek J.B., Kiyatkin A. Cellular Signalling 2010, 22:1369.
15. McCubrey J.A., Sokolosky M.L., Lehmann B.D., Taylor J.R., Navolanic P.M., Chappell W.H., Abrams S.L., Stadelman K.M., Wong E.W., Misaghian N., Horn S., Bäsecke J., Libra M., Stivala F., Ligresti G., Tafuri A., Milella M., Zarzycki M., Dzugaj A., Chiarini F., Evangelisti C., Martelli A.M., Terrian D.M., Franklin R.A., Steelman L.S. Advances in Enzyme Regulation 2008, 48:113.
16. Franklin M.C., Carey K.D., Vajdos F.F., Leahy D.J., de Vos A.M., Sliwkowski M.X. Cancer Cell 2004, 5:317.
17. Giamas G., Man Y.L., Hirner H., Bischof J., Kramer K., Khan K., Ahmed S.S., Stebbing J., Knippschild U. Cellular Signalling 2010, 22:984.
18. Nagumo Y., Faratian D., Mullen P., Harrison D.J., Hasmann M., Langdon S.P. Molecular Cancer Research 2009, 7:1563.
19. Langdon S.P., Faratian D., Nagumo Y., Mullen P., Harrison D.J. Expert Opinion on Biological Therapy 2010, 10:1113.
20. Singer C.F., Köstler W.J., Hudelist G. Biochimica et Biophysica Acta 2008, 1786:105.
21. Engelman J.A., Settleman J. Current Opinion in Genetics and Development 2008, 18:73.
22. Leslie N.R., Downes C.P. Biochemical Journal 2004, 382:1.
23. Engelman J.A. Nature Reviews. Cancer 2009, 9:550.
24. Stemke-Hale K., Gonzalez-Angulo A.M., Lluch A., Neve R.M. Cancer Research 2008, 68:6084.
25. Berns K. Cell 2007, 12:395.
26. Liedtke C., Cardone L., Tordai A., Yan K., Gomez H.L., Figureoa L.J., Hubbard R.E., Valero V., Souchon E.A., Symmans W.F., Hortobagyi G.N., Bardelli A., Pusztai L. Breast Cancer Research 2008, 10:R27.
27. Nagata Y., Lan K.H., Zhou X., Tan M., Esteva F.J., Sahin A.A., Klos K.S., Li P., Monia B.P., Nguyen N.T., Hortobagyi G.N., Hung M.C., Yu D. Cancer Cell 2004, 6:117.
28. Marty B., Maire V., Gravier E., Rigaill G., Vincent-Salomon A., Kappler M., Lebigot I., Djelti F., Tourdès A., Gestraud P., Hupé P., Barillot E., Cruzalegui F., Tucker G.C., Stern M.H., Thiery J.P., Hickman J.A., Dubois T. Breast Cancer Research 2008, 10:R101.
29. Pérez-Tenorio G., Alkhori L., Olsson B., Waltersson M.A., Nordenskjöld B., Rutqvist L.E., Skoog L., Stål O. Clinical Cancer Research 2007, 13:3577.
30. Saal L.H., Holm K., Maurer M., Memeo L., Su T., Wang X., Yu J.S., Malmström P.O., Mansukhani M., Enoksson J., Hibshoosh H., Borg A., Parsons R. Cancer Research 2005, 65:2554.
31. O'Brien N.A., Browne B.C., Chow L., Wang Y., Ginther C., Arboleda J., Duffy M.J., Crown J., O'Donovan N., Slamon D.J. Molecular Cancer Therapeutics 2010, 9:1489.
32. Faratian D., Goltsov A., Lebedeva G., Moodie S., Mullen P., Kay C., Um I.H., Langdon S., Goryanin I., Harrison D.J. Cancer Research 2009, 69:6713.
33. Goltsov A., Faratian D., Langdon S.P., Bown J., Goryanin I., Harrison D.J. Cellular Signalling 2011, 23:407.
34. Park C.S., Schneider I.C., Haugh J.M. Journal of Biological Chemistry 2003, 278:37064.
35. Martelli A.M., Faenza I., Billi A.M., Manzoli L., Evangelisti C., Falà F., Cocco L. Cellular Signalling 2006, 18:1101.
36. Zi Z., Zheng Y., Rundell A.E., Klipp E. BMC Bioinformatics 2008, 9:342.
37. Kitano H. Nature Reviews. Cancer 2004, 4:227.
38. Park J.W., Neve R.M., Szollosi J., Benz C.C. Clinical Breast Cancer 2008, 8:392.
39. Diermeier S., Horváth G., Knuechel-Clarke R., Hofstaedter F., Szöllosi J., Brockhoff G. Experimental Cell Research 2005, 304:604.
40. H. Huizhong. HER receptor-mediated dynamic signalling in breast cancer cells. PhD thesis. School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, 2011.
41. Schmid A.C., Byrne R.D., Vilar R., Woscholski R. FEBS Letters 2004, 566:35.
42. Baselga J., Gelmon K.A., Verma S., Wardley A., Conte P., Miles D., Bianchi G., Cortes J., McNally V.A., Ross G.A., Fumoleau P., Gianni L. Journal of Clinical Oncology 2010, 28:1138.
43. Nakajima H., Sakaguchi K., Fujiwara I., Mizuta M., Tsuruga M., Magae J., Mizuta N. Biochemical and Biophysical Research Communications 2007, 356:260.
44. Deleu S., Choi K., Pesesse X., Cho J., Sulis M.L., Parsons R., Shears S.B. Cellular Signalling 2006, 18:488.
45. Barata J.T. Advances in Enzyme Regulation 2011, 51:37.
46. Luo J. Cancer Letters 2009, 273:194.
47. Orton R.J., Adriaens M.E., Gormand A., Sturm O.E., Kolch W., Gilbert D.R. BMC Systems Biology 2009, 3:100.
48. Vanhaesebroeck B., Alessi D.R. Biochemical Journal 2000, 346:561.
49. Peifer C., Alessi D.R. ChemMedChem 2008, 3:1810.
50. Bijman M.N., van Berkel M.P., Kok M., Janmaat M.L., Boven E. Anti-Cancer Drugs 2009, 20:450.