-
1
-
-
60749137451
-
Beyond chemotherapy: Targeted therapies in ovarian cancer
-
Yap TA, Carden CP, Kaye SB. Beyond chemotherapy: targeted therapies in ovarian cancer. Nat Rev Cancer 2009;10:167-181
-
(2009)
Nat Rev Cancer
, vol.10
, pp. 167-181
-
-
Yap, T.A.1
Carden, C.P.2
Kaye, S.B.3
-
3
-
-
16244403039
-
Cancer incidence and mortality in Europe 2004
-
Boyle P, Ferlay J. Cancer incidence and mortality in Europe, 2004. Ann Oncol 2005;16:481-488
-
(2005)
Ann Oncol
, vol.16
, pp. 481-488
-
-
Boyle, P.1
Ferlay, J.2
-
4
-
-
0142009691
-
Phase 2 trial of single-agent gemcitabine in platinum-paclitaxel refractory ovarian cancer
-
Markman M, Webster K, Zanotti K, et al. Phase 2 trial of single-agent gemcitabine in platinum-paclitaxel refractory ovarian cancer. Gynecol Oncol 2003;90:593-606
-
(2003)
Gynecol Oncol
, vol.90
, pp. 593-606
-
-
Markman, M.1
Webster, K.2
Zanotti, K.3
-
5
-
-
0037339485
-
Phase II study of gemcitabine in recurrent platinum-and paclitaxel-resistant ovarian cancer
-
DOI 10.1016/S0090-8258(03)00011-8
-
D'Agostino G, Amant F, Berteloot P, et al. Phase II study of gemcitabine in recurrent platinumand paclitaxel-resistant ovarian cancer. Gynecol Oncol 2003;88:266-269 (Pubitemid 36331977)
-
(2003)
Gynecologic Oncology
, vol.88
, Issue.3
, pp. 266-269
-
-
D'Agostino, G.1
Amant, F.2
Berteloot, P.3
Scambia, G.4
Vergote, I.5
-
6
-
-
0043240182
-
Ovarian cancer: Strategies to overcome resistance to chemotherapy
-
Agarwal R, Kaye S. Ovarian cancer: strategies to overcome resistance to chemotherapy. Nat Rev Cancer 2003;3:502-516
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 502-516
-
-
Agarwal, R.1
Kaye, S.2
-
7
-
-
51749099175
-
The emerging role of epidermal growth factor receptor inhibitors in ovarian cancer
-
Palayejkar MJ, Herzog TJ. The emerging role of epidermal growth factor receptor inhibitors in ovarian cancer. Int J Gynecol Cancer 2008;18:879-890
-
(2008)
Int J Gynecol Cancer
, vol.18
, pp. 879-890
-
-
Palayejkar, M.J.1
Herzog, T.J.2
-
8
-
-
2542555865
-
A new therapeutic antibody masks erbB2 to its partners
-
Badache A, Hynes NE. A new therapeutic antibody masks erbB2 to its partners. Cancer Cell 2004;5:299-301
-
(2004)
Cancer Cell
, vol.5
, pp. 299-301
-
-
Badache, A.1
Hynes, N.E.2
-
11
-
-
18344390418
-
ErbB receptors and cancer: The complexity of targeted inhibitors
-
Hynes NE, Lane HA. ErbB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005;5:341-354
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
12
-
-
34547854801
-
The oncogene HER2: Its signalling and transforming functions and its role in human cancer pathogenesis
-
Moasser MM. The oncogene HER2: its signalling and transforming functions and its role in human cancer pathogenesis. Oncogene 2007;26:6469-6487
-
(2007)
Oncogene
, vol.26
, pp. 6469-6487
-
-
Moasser, M.M.1
-
13
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors is a mediator of lateral signalling
-
Graus-Porta D, Beerli RR, Daly JM, et al. ErbB-2, the preferred heterodimerization partner of all ErbB receptors is a mediator of lateral signalling. EMBO J 1997;16:1647-1655
-
(1997)
EMBO J
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
-
14
-
-
0037434791
-
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
-
Cho HS, Mason K, Ramyar KX, et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003;421:756-760
-
(2003)
Nature
, vol.421
, pp. 756-760
-
-
Cho, H.S.1
Mason, K.2
Ramyar, K.X.3
-
15
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-712
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
-
16
-
-
0025281906
-
Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer
-
Berchuck A, Kamel A, Whitaker R, et al. Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 1990;50:4087-4091
-
(1990)
Cancer Res
, vol.50
, pp. 4087-4091
-
-
Berchuck, A.1
Kamel, A.2
Whitaker, R.3
-
17
-
-
0028082242
-
Overexpression of the oncogene c-erb B2 in primary ovarian cancer: Evaluation of the prognostic value in a Cox proportional hazards multiple regression
-
Meden H, Marx D, Rath W. Overexpression of the oncogene c-erb B2 in primary ovarian cancer: evaluation of the prognostic value in a Cox proportional hazards multiple regression. Int J Gynecol Pathol 1994;13:45-53
-
(1994)
Int J Gynecol Pathol
, vol.13
, pp. 45-53
-
-
Meden, H.1
Marx, D.2
Rath, W.3
-
18
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
Agus DB, Akita RW, Fox WD, et al. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2002;2:127-137
-
(2002)
Cancer Cell
, vol.2
, pp. 127-137
-
-
Agus, D.B.1
Akita, R.W.2
Fox, W.D.3
-
19
-
-
22344457603
-
Combination treatment with erlotinib and pertuzumab against human tumor xenografts is superior to monotherapy
-
Friess T, Scheuer W, Hasmann M. Combination treatment with erlotinib and pertuzumab against human tumor xenografts is superior to monotherapy. Clin Cancer Res 2005;11:5300-5309
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5300-5309
-
-
Friess, T.1
Scheuer, W.2
Hasmann, M.3
-
20
-
-
1942441770
-
Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects
-
Jackson JG, St Clair P, Sliwkowski MX, et al. Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects. Cancer Res 2004;64:2601-2609
-
(2004)
Cancer Res
, vol.64
, pp. 2601-2609
-
-
Jackson, J.G.1
St Clair, P.2
Sliwkowski, M.X.3
-
21
-
-
33846818624
-
Sensitivity to pertuzumab (2C4) in ovarian cancer models: Cross-talk with estrogen receptor signalling
-
Mullen P, Cameron DA, Hasmann M, et al. Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signalling. Mol Cancer Ther 2007;6:93-100
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 93-100
-
-
Mullen, P.1
Cameron, D.A.2
Hasmann, M.3
-
22
-
-
29144434036
-
2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth
-
Takai N, Jain A, Kawamata N, et al. 2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth. Cancer 2005;104:2701-2708
-
(2005)
Cancer
, vol.104
, pp. 2701-2708
-
-
Takai, N.1
Jain, A.2
Kawamata, N.3
-
23
-
-
77949900758
-
Clinical Activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer
-
Makhija S, Amler LC, Glenn D, et al. Clinical Activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. J Clin Oncol 2010;28:1215-1223
-
(2010)
J Clin Oncol
, vol.28
, pp. 1215-1223
-
-
Makhija, S.1
Amler, L.C.2
Glenn, D.3
-
24
-
-
70349487546
-
Modulation of HER3 is a marker of dynamic cell signaling in ovarian cancer: Implications for pertuzumab sensitivity
-
Nagumo Y, Faratian D, Mullen P, et al. Modulation of HER3 is a marker of dynamic cell signaling in ovarian cancer: implications for pertuzumab sensitivity. Mol Cancer Res 2009;7:1563-1571
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1563-1571
-
-
Nagumo, Y.1
Faratian, D.2
Mullen, P.3
-
25
-
-
20244378677
-
Phase i clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
-
Agus DB, Gordon MS, Taylor C, et al. Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. J Clin Oncol 2005;23:2534-2543
-
(2005)
J Clin Oncol
, vol.23
, pp. 2534-2543
-
-
Agus, D.B.1
Gordon, M.S.2
Taylor, C.3
-
26
-
-
33749003463
-
Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: Potential predictive relationship with tumor HER2 activation status
-
Gordon MS, Matei D, Aghajanian C, et al. Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status. J Clin Oncol 2006;24:4324-4332
-
(2006)
J Clin Oncol
, vol.24
, pp. 4324-4332
-
-
Gordon, M.S.1
Matei, D.2
Aghajanian, C.3
-
27
-
-
60749131575
-
A randomised phase II study evaluating the combination of carboplatin-based chemotherapy with pertuzumab versus carboplatin based therapy alone in patients with relapsed,platinum sensitive ovarian cancer [abstract 5520]
-
Kaye SB, Poole CJ, Bidzinksi M, et al. A randomised phase II study evaluating the combination of carboplatin-based chemotherapy with pertuzumab versus carboplatin based therapy alone in patients with relapsed,platinum sensitive ovarian cancer [abstract 5520]. J Clin Oncol 2008;26(Suppl):305s
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Kaye, S.B.1
Poole, C.J.2
Bidzinksi, M.3
-
28
-
-
77953344035
-
-
ASCO Media Player.Available at:, Last accessed 28 April
-
ASCO Media Player. Available at: http://media.asco.org/silver/ AstuteMediaPlayer.aspx?ConferenceID= 55&TrackID=5&SessionID=392& PresentationID=11974&Token [Last accessed 28 April 2010]
-
(2010)
-
-
-
29
-
-
34347395733
-
Mechanism of action and use in clinical practice
-
Hudis CA. Mechanism of action and use in clinical practice. N Engl J Med 2007;357:39-51
-
(2007)
N Engl J Med
, vol.357
, pp. 39-51
-
-
Hudis, C.A.1
-
30
-
-
0037440042
-
Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: A phase II trial of the Gynecologic Oncology Group
-
Bookman MA, Darcy KM, Clarke-Pearson D, et al. Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase II trial of the Gynecologic Oncology Group. J Clin Oncol 2003;21:283-290
-
(2003)
J Clin Oncol
, vol.21
, pp. 283-290
-
-
Ma, B.1
Darcy, K.M.2
Clarke-Pearson, D.3
-
31
-
-
23944476155
-
Phase i safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
-
Burris HA, Hurwitz HI, Dees EC, et al. Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J Clin Oncol 2005;23:5305-5313
-
(2005)
J Clin Oncol
, vol.23
, pp. 5305-5313
-
-
Burris, H.A.1
Hurwitz, H.I.2
Dees, E.C.3
-
32
-
-
60749111692
-
Phase I/II lapatinib plus carboplatin and paclitaxel in stage III or IV relapsed ovarian cancer patients
-
Rivkin SE, Muller D, Iriarte D, et al. Phase I/II lapatinib plus carboplatin and paclitaxel in stage III or IV relapsed ovarian cancer patients. J Clin Oncol 2008;26:5556
-
(2008)
J Clin Oncol
, vol.26
, pp. 5556
-
-
Rivkin, S.E.1
Muller, D.2
Iriarte, D.3
-
33
-
-
52049112530
-
A phase i study of lapatinib in combination with carboplatin in women with platinum sensitive recurrent ovarian carcinoma
-
Kimball KJ, Numnum TM, Kirby TO, et al. A phase I study of lapatinib in combination with carboplatin in women with platinum sensitive recurrent ovarian carcinoma. Gynecol Oncol 2008;111:95-101
-
(2008)
Gynecol Oncol
, vol.111
, pp. 95-101
-
-
Kimball, K.J.1
Numnum, T.M.2
Kirby, T.O.3
-
34
-
-
24944486001
-
Multicenter randomized phase II trial of oral CI-1033 for previously treated advanced ovarian cancer
-
Campos S, Hamid O, Seiden MV, et al. Multicenter randomized phase II trial of oral CI-1033 for previously treated advanced ovarian cancer. J Clin Oncol 2005;23:5597-5604
-
(2005)
J Clin Oncol
, vol.23
, pp. 5597-5604
-
-
Campos, S.1
Hamid, O.2
Seiden, M.V.3
-
35
-
-
77949903478
-
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
-
Balsega J, Gelmon KA, Verma S, et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 2010;28:1138-1144
-
(2010)
J Clin Oncol
, vol.28
, pp. 1138-1144
-
-
Balsega, J.1
Gelmon, K.A.2
Verma, S.3
-
36
-
-
73649149433
-
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
-
Scheuer W, Friess T, Burtscher H, et al. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res 2009;69:9330-9336
-
(2009)
Cancer Res
, vol.69
, pp. 9330-9336
-
-
Scheuer, W.1
Friess, T.2
Burtscher, H.3
|