PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells

Cellular Signalling

Volumn 22, Issue 9, 2010, Pages 1369-1378

  Aksamitiene, Edita ^a   Kholodenko, Boris N ^a,b   Kolch, Walter ^b   Hoek, Jan B ^a   Kiyatkin, Anatoly ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Breast cancer resistance; Crosstalk; EGF signaling; ERK activation; MEK inhibition; PI3K Akt

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 6; MUTANT PROTEIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; WORTMANNIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER RESISTANCE; CELL GROWTH; CELL STRAIN MCF 7; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE SILENCING; HUMAN; HUMAN CELL; MITOGENICITY; PRIORITY JOURNAL; RNA INTERFERENCE; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; WILD TYPE;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL LINE, TUMOR; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ESTROGEN;

EID: 77953719496     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2010.05.006     Document Type: Article

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