-
1
-
-
0028349997
-
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
-
Brannan C.I., Perkins A.S., Vogel K.S., Ratner N., Nordlund M.L., Reid S.W., Buchberg A.M., Jenkins N.A., Parada L.F., Copeland N.G. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 1994, 8:1019-1029.
-
(1994)
Genes Dev.
, vol.8
, pp. 1019-1029
-
-
Brannan, C.I.1
Perkins, A.S.2
Vogel, K.S.3
Ratner, N.4
Nordlund, M.L.5
Reid, S.W.6
Buchberg, A.M.7
Jenkins, N.A.8
Parada, L.F.9
Copeland, N.G.10
-
2
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068. Cancer Genome Atlas Research Network.
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
3
-
-
0035936783
-
NF1 tumor suppressor gene function: narrowing the GAP
-
Cichowski K., Jacks T. NF1 tumor suppressor gene function: narrowing the GAP. Cell 2001, 104:593-604.
-
(2001)
Cell
, vol.104
, pp. 593-604
-
-
Cichowski, K.1
Jacks, T.2
-
4
-
-
0037443055
-
Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor
-
Cichowski K., Santiago S., Jardim M., Johnson B.W., Jacks T. Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. Genes Dev. 2003, 17:449-454.
-
(2003)
Genes Dev.
, vol.17
, pp. 449-454
-
-
Cichowski, K.1
Santiago, S.2
Jardim, M.3
Johnson, B.W.4
Jacks, T.5
-
5
-
-
0037203821
-
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
-
Costa R.M., Federov N.B., Kogan J.H., Murphy G.G., Stern J., Ohno M., Kucherlapati R., Jacks T., Silva A.J. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature 2002, 415:526-530.
-
(2002)
Nature
, vol.415
, pp. 526-530
-
-
Costa, R.M.1
Federov, N.B.2
Kogan, J.H.3
Murphy, G.G.4
Stern, J.5
Ohno, M.6
Kucherlapati, R.7
Jacks, T.8
Silva, A.J.9
-
6
-
-
54549106766
-
Neurofibromin regulation of ERK signaling modulates GABA release and learning
-
Cui Y., Costa R.M., Murphy G.G., Elgersma Y., Zhu Y., Gutmann D.H., Parada L.F., Mody I., Silva A.J. Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell 2008, 135:549-560.
-
(2008)
Cell
, vol.135
, pp. 549-560
-
-
Cui, Y.1
Costa, R.M.2
Murphy, G.G.3
Elgersma, Y.4
Zhu, Y.5
Gutmann, D.H.6
Parada, L.F.7
Mody, I.8
Silva, A.J.9
-
8
-
-
34248583886
-
MAP kinase signalling pathways in cancer
-
Dhillon A.S., Hagan S., Rath O., Kolch W. MAP kinase signalling pathways in cancer. Oncogene 2007, 26:3279-3290.
-
(2007)
Oncogene
, vol.26
, pp. 3279-3290
-
-
Dhillon, A.S.1
Hagan, S.2
Rath, O.3
Kolch, W.4
-
9
-
-
33846562882
-
Phosphatase and feedback regulation of Raf-1 signaling
-
Dhillon A.S., von Kriegsheim A., Grindlay J., Kolch W. Phosphatase and feedback regulation of Raf-1 signaling. Cell Cycle 2007, 6:3-7.
-
(2007)
Cell Cycle
, vol.6
, pp. 3-7
-
-
Dhillon, A.S.1
von Kriegsheim, A.2
Grindlay, J.3
Kolch, W.4
-
10
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding L., Getz G., Wheeler D.A., Mardis E.R., McLellan M.D., Cibulskis K., Sougnez C., Greulich H., Muzny D.M., Morgan M.B., et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008, 455:1069-1075.
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
Mardis, E.R.4
McLellan, M.D.5
Cibulskis, K.6
Sougnez, C.7
Greulich, H.8
Muzny, D.M.9
Morgan, M.B.10
-
11
-
-
6344225681
-
Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases
-
Donaldson T.D., Noureddine M.A., Reynolds P.J., Bradford W., Duronio R.J. Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases. Mol. Biol. Cell 2004, 15:4892-4903.
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 4892-4903
-
-
Donaldson, T.D.1
Noureddine, M.A.2
Reynolds, P.J.3
Bradford, W.4
Duronio, R.J.5
-
12
-
-
0032932201
-
SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents
-
Duan H., Wang Y., Aviram M., Swaroop M., Loo J.A., Bian J., Tian Y., Mueller T., Bisgaier C.L., Sun Y. SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol. Cell. Biol. 1999, 19:3145-3155.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3145-3155
-
-
Duan, H.1
Wang, Y.2
Aviram, M.3
Swaroop, M.4
Loo, J.A.5
Bian, J.6
Tian, Y.7
Mueller, T.8
Bisgaier, C.L.9
Sun, Y.10
-
13
-
-
56949099281
-
The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development
-
Farkas L.M., Huttner W.B. The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development. Curr. Opin. Cell Biol. 2008, 20:707-715.
-
(2008)
Curr. Opin. Cell Biol.
, vol.20
, pp. 707-715
-
-
Farkas, L.M.1
Huttner, W.B.2
-
14
-
-
0037013260
-
Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins
-
Furukawa M., Ohta T., Xiong Y. Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. J. Biol. Chem. 2002, 277:15758-15765.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 15758-15765
-
-
Furukawa, M.1
Ohta, T.2
Xiong, Y.3
-
16
-
-
34248547553
-
SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation
-
Gu Q., Tan M., Sun Y. SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation. Cancer Res. 2007, 67:3616-3625.
-
(2007)
Cancer Res.
, vol.67
, pp. 3616-3625
-
-
Gu, Q.1
Tan, M.2
Sun, Y.3
-
17
-
-
34548846689
-
SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB
-
Gu Q., Bowden G.T., Normolle D., Sun Y. SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB. J. Cell Biol. 2007, 178:1009-1023.
-
(2007)
J. Cell Biol.
, vol.178
, pp. 1009-1023
-
-
Gu, Q.1
Bowden, G.T.2
Normolle, D.3
Sun, Y.4
-
18
-
-
33744542795
-
Raf kinase inhibitor protein regulation of raf and MAPK signaling
-
Hagan S., Garcia R., Dhillon A., Kolch W. Raf kinase inhibitor protein regulation of raf and MAPK signaling. Methods Enzymol. 2006, 407:248-259.
-
(2006)
Methods Enzymol.
, vol.407
, pp. 248-259
-
-
Hagan, S.1
Garcia, R.2
Dhillon, A.3
Kolch, W.4
-
19
-
-
0028788570
-
Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
-
Henkemeyer M., Rossi D.J., Holmyard D.P., Puri M.C., Mbamalu G., Harpal K., Shih T.S., Jacks T., Pawson T. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature 1995, 377:695-701.
-
(1995)
Nature
, vol.377
, pp. 695-701
-
-
Henkemeyer, M.1
Rossi, D.J.2
Holmyard, D.P.3
Puri, M.C.4
Mbamalu, G.5
Harpal, K.6
Shih, T.S.7
Jacks, T.8
Pawson, T.9
-
20
-
-
34848861048
-
Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line
-
Hughes E.D., Qu Y.Y., Genik S.J., Lyons R.H., Pacheco C.D., Lieberman A.P., Samuelson L.C., Nasonkin I.O., Camper S.A., Van Keuren M.L., Saunders T.L. Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line. Mamm. Genome 2007, 18:549-558.
-
(2007)
Mamm. Genome
, vol.18
, pp. 549-558
-
-
Hughes, E.D.1
Qu, Y.Y.2
Genik, S.J.3
Lyons, R.H.4
Pacheco, C.D.5
Lieberman, A.P.6
Samuelson, L.C.7
Nasonkin, I.O.8
Camper, S.A.9
Van Keuren, M.L.10
Saunders, T.L.11
-
21
-
-
26444599545
-
The nature and frequency of cognitive deficits in children with neurofibromatosis type 1
-
Hyman S.L., Shores A., North K.N. The nature and frequency of cognitive deficits in children with neurofibromatosis type 1. Neurology 2005, 65:1037-1044.
-
(2005)
Neurology
, vol.65
, pp. 1037-1044
-
-
Hyman, S.L.1
Shores, A.2
North, K.N.3
-
22
-
-
33751109941
-
Learning disabilities in children with neurofibromatosis type 1: subtypes, cognitive profile, and attention-deficit-hyperactivity disorder
-
Hyman S.L., Arthur Shores E., North K.N. Learning disabilities in children with neurofibromatosis type 1: subtypes, cognitive profile, and attention-deficit-hyperactivity disorder. Dev. Med. Child Neurol. 2006, 48:973-977.
-
(2006)
Dev. Med. Child Neurol.
, vol.48
, pp. 973-977
-
-
Hyman, S.L.1
Arthur Shores, E.2
North, K.N.3
-
23
-
-
0028307836
-
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
-
Jacks T., Shih T.S., Schmitt E.M., Bronson R.T., Bernards A., Weinberg R.A. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat. Genet. 1994, 7:353-361.
-
(1994)
Nat. Genet.
, vol.7
, pp. 353-361
-
-
Jacks, T.1
Shih, T.S.2
Schmitt, E.M.3
Bronson, R.T.4
Bernards, A.5
Weinberg, R.A.6
-
24
-
-
76049102305
-
Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target
-
Jia L., Yang J., Hao X., Zheng M., He H., Xiong X., Xu L., Sun Y. Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target. Clin. Cancer Res. 2010, 16:814-824.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 814-824
-
-
Jia, L.1
Yang, J.2
Hao, X.3
Zheng, M.4
He, H.5
Xiong, X.6
Xu, L.7
Sun, Y.8
-
25
-
-
79952787761
-
RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins
-
Jia L., Bickel J.S., Wu J., Morgan M.A., Li H., Yang J., Yu X., Chan R.C., Sun Y. RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. J. Biol. Chem. 2011, 286:3379-3386.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 3379-3386
-
-
Jia, L.1
Bickel, J.S.2
Wu, J.3
Morgan, M.A.4
Li, H.5
Yang, J.6
Yu, X.7
Chan, R.C.8
Sun, Y.9
-
26
-
-
7544234937
-
Systematic analysis and nomenclature of mammalian F-box proteins
-
Jin J., Cardozo T., Lovering R.C., Elledge S.J., Pagano M., Harper J.W. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 2004, 18:2573-2580.
-
(2004)
Genes Dev.
, vol.18
, pp. 2573-2580
-
-
Jin, J.1
Cardozo, T.2
Lovering, R.C.3
Elledge, S.J.4
Pagano, M.5
Harper, J.W.6
-
27
-
-
0033597443
-
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
-
Kamura T., Koepp D.M., Conrad M.N., Skowyra D., Moreland R.J., Iliopoulos O., Lane W.S., Kaelin W.G., Elledge S.J., Conaway R.C., et al. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science 1999, 284:657-661.
-
(1999)
Science
, vol.284
, pp. 657-661
-
-
Kamura, T.1
Koepp, D.M.2
Conrad, M.N.3
Skowyra, D.4
Moreland, R.J.5
Iliopoulos, O.6
Lane, W.S.7
Kaelin, W.G.8
Elledge, S.J.9
Conaway, R.C.10
-
28
-
-
10644276385
-
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
-
Kamura T., Maenaka K., Kotoshiba S., Matsumoto M., Kohda D., Conaway R.C., Conaway J.W., Nakayama K.I. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev. 2004, 18:3055-3065.
-
(2004)
Genes Dev.
, vol.18
, pp. 3055-3065
-
-
Kamura, T.1
Maenaka, K.2
Kotoshiba, S.3
Matsumoto, M.4
Kohda, D.5
Conaway, R.C.6
Conaway, J.W.7
Nakayama, K.I.8
-
30
-
-
42049112366
-
Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells
-
Kawasaki K., Watabe T., Sase H., Hirashima M., Koide H., Morishita Y., Yuki K., Sasaoka T., Suda T., Katsuki M., et al. Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells. J. Cell Biol. 2008, 181:131-141.
-
(2008)
J. Cell Biol.
, vol.181
, pp. 131-141
-
-
Kawasaki, K.1
Watabe, T.2
Sase, H.3
Hirashima, M.4
Koide, H.5
Morishita, Y.6
Yuki, K.7
Sasaoka, T.8
Suda, T.9
Katsuki, M.10
-
31
-
-
0038420033
-
HCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53
-
Kimura T., Gotoh M., Nakamura Y., Arakawa H. hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53. Cancer Sci. 2003, 94:431-436.
-
(2003)
Cancer Sci.
, vol.94
, pp. 431-436
-
-
Kimura, T.1
Gotoh, M.2
Nakamura, Y.3
Arakawa, H.4
-
32
-
-
27644575157
-
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
-
Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat. Rev. Mol. Cell Biol. 2005, 6:827-837.
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 827-837
-
-
Kolch, W.1
-
34
-
-
34347372927
-
Tumor microenvironment and neurofibromatosis type I: connecting the GAPs
-
Le L.Q., Parada L.F. Tumor microenvironment and neurofibromatosis type I: connecting the GAPs. Oncogene 2007, 26:4609-4616.
-
(2007)
Oncogene
, vol.26
, pp. 4609-4616
-
-
Le, L.Q.1
Parada, L.F.2
-
35
-
-
10644269326
-
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
-
Mao J.H., Perez-Losada J., Wu D., Delrosario R., Tsunematsu R., Nakayama K.I., Brown K., Bryson S., Balmain A. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 2004, 432:775-779.
-
(2004)
Nature
, vol.432
, pp. 775-779
-
-
Mao, J.H.1
Perez-Losada, J.2
Wu, D.3
Delrosario, R.4
Tsunematsu, R.5
Nakayama, K.I.6
Brown, K.7
Bryson, S.8
Balmain, A.9
-
36
-
-
77950090066
-
Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts
-
Masuda K., Ishikawa Y., Onoyama I., Unno M., de Alborán I.M., Nakayama K.I., Nakayama K. Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts. Oncogene 2010, 29:1798-1809.
-
(2010)
Oncogene
, vol.29
, pp. 1798-1809
-
-
Masuda, K.1
Ishikawa, Y.2
Onoyama, I.3
Unno, M.4
de Alborán, I.M.5
Nakayama, K.I.6
Nakayama, K.7
-
37
-
-
67649321430
-
Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis
-
McGillicuddy L.T., Fromm J.A., Hollstein P.E., Kubek S., Beroukhim R., De Raedt T., Johnson B.W., Williams S.M., Nghiemphu P., Liau L.M., et al. Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis. Cancer Cell 2009, 16:44-54.
-
(2009)
Cancer Cell
, vol.16
, pp. 44-54
-
-
McGillicuddy, L.T.1
Fromm, J.A.2
Hollstein, P.E.3
Kubek, S.4
Beroukhim, R.5
De Raedt, T.6
Johnson, B.W.7
Williams, S.M.8
Nghiemphu, P.9
Liau, L.M.10
-
38
-
-
1042291144
-
Analysis of RING finger genes required for embryogenesis in C. elegans
-
Moore R., Boyd L. Analysis of RING finger genes required for embryogenesis in C. elegans. Genesis 2004, 38:1-12.
-
(2004)
Genesis
, vol.38
, pp. 1-12
-
-
Moore, R.1
Boyd, L.2
-
39
-
-
33646345376
-
Ubiquitin ligases: cell-cycle control and cancer
-
Nakayama K.I., Nakayama K. Ubiquitin ligases: cell-cycle control and cancer. Nat. Rev. Cancer 2006, 6:369-381.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 369-381
-
-
Nakayama, K.I.1
Nakayama, K.2
-
41
-
-
33644878125
-
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse
-
Database issue
-
Nord A.S., Chang P.J., Conklin B.R., Cox A.V., Harper C.A., Hicks G.G., Huang C.C., Johns S.J., Kawamoto M., Liu S., et al. The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res. 2006, 34(Database issue):D642-D648.
-
(2006)
Nucleic Acids Res.
, vol.34
-
-
Nord, A.S.1
Chang, P.J.2
Conklin, B.R.3
Cox, A.V.4
Harper, C.A.5
Hicks, G.G.6
Huang, C.C.7
Johns, S.J.8
Kawamoto, M.9
Liu, S.10
-
42
-
-
0033120027
-
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
-
Ohta T., Michel J.J., Schottelius A.J., Xiong Y. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol. Cell 1999, 3:535-541.
-
(1999)
Mol. Cell
, vol.3
, pp. 535-541
-
-
Ohta, T.1
Michel, J.J.2
Schottelius, A.J.3
Xiong, Y.4
-
43
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons D.W., Jones S., Zhang X., Lin J.C., Leary R.J., Angenendt P., Mankoo P., Carter H., Siu I.M., Gallia G.L., et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008, 321:1807-1812.
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Siu, I.M.9
Gallia, G.L.10
-
44
-
-
11244351579
-
Function and regulation of cullin-RING ubiquitin ligases
-
Petroski M.D., Deshaies R.J. Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 2005, 6:9-20.
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 9-20
-
-
Petroski, M.D.1
Deshaies, R.J.2
-
45
-
-
77950662360
-
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans
-
Phan V.T., Ding V.W., Li F., Chalkley R.J., Burlingame A., McCormick F. The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Mol. Cell. Biol. 2010, 30:2264-2279.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 2264-2279
-
-
Phan, V.T.1
Ding, V.W.2
Li, F.3
Chalkley, R.J.4
Burlingame, A.5
McCormick, F.6
-
46
-
-
1542377277
-
Inactivation of hCDC4 can cause chromosomal instability
-
Rajagopalan H., Jallepalli P.V., Rago C., Velculescu V.E., Kinzler K.W., Vogelstein B., Lengauer C. Inactivation of hCDC4 can cause chromosomal instability. Nature 2004, 428:77-81.
-
(2004)
Nature
, vol.428
, pp. 77-81
-
-
Rajagopalan, H.1
Jallepalli, P.V.2
Rago, C.3
Velculescu, V.E.4
Kinzler, K.W.5
Vogelstein, B.6
Lengauer, C.7
-
47
-
-
51449106498
-
Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping
-
Reynolds P.J., Simms J.R., Duronio R.J. Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping. PLoS ONE 2008, 3:e2918.
-
(2008)
PLoS ONE
, vol.3
-
-
Reynolds, P.J.1
Simms, J.R.2
Duronio, R.J.3
-
48
-
-
57349132432
-
Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations
-
Sangha N., Wu R., Kuick R., Powers S., Mu D., Fiander D., Yuen K., Katabuchi H., Tashiro H., Fearon E.R., et al. Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations. Neoplasia 2008, 10:1362-1372.
-
(2008)
Neoplasia
, vol.10
, pp. 1362-1372
-
-
Sangha, N.1
Wu, R.2
Kuick, R.3
Powers, S.4
Mu, D.5
Fiander, D.6
Yuen, K.7
Katabuchi, H.8
Tashiro, H.9
Fearon, E.R.10
-
49
-
-
0242456201
-
Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis
-
Sasagawa Y., Urano T., Kohara Y., Takahashi H., Higashitani A. Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis. Genes Cells 2003, 8:857-872.
-
(2003)
Genes Cells
, vol.8
, pp. 857-872
-
-
Sasagawa, Y.1
Urano, T.2
Kohara, Y.3
Takahashi, H.4
Higashitani, A.5
-
50
-
-
0035923305
-
Expression of the sensitive to apoptosis gene, SAG, as a prognostic marker in nonsmall cell lung cancer
-
Sasaki H., Yukiue H., Kobayashi Y., Moriyama S., Nakashima Y., Kaji M., Fukai I., Kiriyama M., Yamakawa Y., Fujii Y. Expression of the sensitive to apoptosis gene, SAG, as a prognostic marker in nonsmall cell lung cancer. Int. J. Cancer 2001, 95:375-377.
-
(2001)
Int. J. Cancer
, vol.95
, pp. 375-377
-
-
Sasaki, H.1
Yukiue, H.2
Kobayashi, Y.3
Moriyama, S.4
Nakashima, Y.5
Kaji, M.6
Fukai, I.7
Kiriyama, M.8
Yamakawa, Y.9
Fujii, Y.10
-
51
-
-
20244389988
-
Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
-
Seol J.H., Feldman R.M.R., Zachariae W.Z., Shevchenko A., Correll C.C., Lyapina S., Chi Y., Galova M., Claypool J., Sandmeyer S., et al. Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Genes Dev. 1999, 13:1614-1626.
-
(1999)
Genes Dev.
, vol.13
, pp. 1614-1626
-
-
Seol, J.H.1
Feldman, R.M.R.2
Zachariae, W.Z.3
Shevchenko, A.4
Correll, C.C.5
Lyapina, S.6
Chi, Y.7
Galova, M.8
Claypool, J.9
Sandmeyer, S.10
-
52
-
-
22344434300
-
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
-
Shen T.L., Park A.Y., Alcaraz A., Peng X., Jang I., Koni P., Flavell R.A., Gu H., Guan J.L. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J. Cell Biol. 2005, 169:941-952.
-
(2005)
J. Cell Biol.
, vol.169
, pp. 941-952
-
-
Shen, T.L.1
Park, A.Y.2
Alcaraz, A.3
Peng, X.4
Jang, I.5
Koni, P.6
Flavell, R.A.7
Gu, H.8
Guan, J.L.9
-
53
-
-
0032877005
-
Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection
-
Sun Y. Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection. Carcinogenesis 1999, 20:1899-1903.
-
(1999)
Carcinogenesis
, vol.20
, pp. 1899-1903
-
-
Sun, Y.1
-
54
-
-
33748521536
-
E3 ubiquitin ligases as cancer targets and biomarkers
-
Sun Y. E3 ubiquitin ligases as cancer targets and biomarkers. Neoplasia 2006, 8:645-654.
-
(2006)
Neoplasia
, vol.8
, pp. 645-654
-
-
Sun, Y.1
-
55
-
-
0034871084
-
SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions
-
Sun Y., Tan M., Duan H., Swaroop M. SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions. Antioxid. Redox Signal. 2001, 3:635-650.
-
(2001)
Antioxid. Redox Signal.
, vol.3
, pp. 635-650
-
-
Sun, Y.1
Tan, M.2
Duan, H.3
Swaroop, M.4
-
56
-
-
0034213598
-
Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation
-
Swaroop M., Wang Y., Miller P., Duan H., Jatkoe T., Madore S.J., Sun Y. Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. Oncogene 2000, 19:2855-2866.
-
(2000)
Oncogene
, vol.19
, pp. 2855-2866
-
-
Swaroop, M.1
Wang, Y.2
Miller, P.3
Duan, H.4
Jatkoe, T.5
Madore, S.J.6
Sun, Y.7
-
57
-
-
0033120593
-
Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha
-
Tan P., Fuchs S.Y., Chen A., Wu K., Gomez C., Ronai Z., Pan Z.-Q. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. Mol. Cell 1999, 3:527-533.
-
(1999)
Mol. Cell
, vol.3
, pp. 527-533
-
-
Tan, P.1
Fuchs, S.Y.2
Chen, A.3
Wu, K.4
Gomez, C.5
Ronai, Z.6
Pan, Z.-Q.7
-
58
-
-
39849098721
-
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation
-
Tan M., Gu Q., He H., Pamarthy D., Semenza G.L., Sun Y. SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation. Oncogene 2008, 27:1404-1411.
-
(2008)
Oncogene
, vol.27
, pp. 1404-1411
-
-
Tan, M.1
Gu, Q.2
He, H.3
Pamarthy, D.4
Semenza, G.L.5
Sun, Y.6
-
59
-
-
65549122047
-
RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27
-
Tan M., Davis S.W., Saunders T.L., Zhu Y., Sun Y. RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27. Proc. Natl. Acad. Sci. USA 2009, 106:6203-6208.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 6203-6208
-
-
Tan, M.1
Davis, S.W.2
Saunders, T.L.3
Zhu, Y.4
Sun, Y.5
-
60
-
-
1542409037
-
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
-
Tetzlaff M.T., Yu W., Li M., Zhang P., Finegold M., Mahon K., Harper J.W., Schwartz R.J., Elledge S.J. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc. Natl. Acad. Sci. USA 2004, 101:3338-3345.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3338-3345
-
-
Tetzlaff, M.T.1
Yu, W.2
Li, M.3
Zhang, P.4
Finegold, M.5
Mahon, K.6
Harper, J.W.7
Schwartz, R.J.8
Elledge, S.J.9
-
61
-
-
1542364470
-
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
-
Tsunematsu R., Nakayama K., Oike Y., Nishiyama M., Ishida N., Hatakeyama S., Bessho Y., Kageyama R., Suda T., Nakayama K.I. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J. Biol. Chem. 2004, 279:9417-9423.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 9417-9423
-
-
Tsunematsu, R.1
Nakayama, K.2
Oike, Y.3
Nishiyama, M.4
Ishida, N.5
Hatakeyama, S.6
Bessho, Y.7
Kageyama, R.8
Suda, T.9
Nakayama, K.I.10
-
62
-
-
65649142176
-
Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model
-
Wang Y., Yang J., Zheng H., Tomasek G.J., Zhang P., McKeever P.E., Lee E.Y., Zhu Y. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 2009, 15:514-526.
-
(2009)
Cancer Cell
, vol.15
, pp. 514-526
-
-
Wang, Y.1
Yang, J.2
Zheng, H.3
Tomasek, G.J.4
Zhang, P.5
McKeever, P.E.6
Lee, E.Y.7
Zhu, Y.8
-
63
-
-
79952853588
-
Small RING finger proteins RBX1 and RBX2 of SCF E3 ubiquitin ligases: the role in cancer and as cancer targets
-
Wei D., Sun Y. Small RING finger proteins RBX1 and RBX2 of SCF E3 ubiquitin ligases: the role in cancer and as cancer targets. Genes & Cancer 2010, 1:700-707.
-
(2010)
Genes & Cancer
, vol.1
, pp. 700-707
-
-
Wei, D.1
Sun, Y.2
-
64
-
-
0033605452
-
Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis
-
Woodruff J.M. Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis. Am. J. Med. Genet. 1999, 89:23-30.
-
(1999)
Am. J. Med. Genet.
, vol.89
, pp. 23-30
-
-
Woodruff, J.M.1
-
65
-
-
0033956753
-
The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation
-
Wu K., Fuchs S.Y., Chen A., Tan P., Gomez C., Ronai Z., Pan Z.Q. The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation. Mol. Cell. Biol. 2000, 20:1382-1393.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 1382-1393
-
-
Wu, K.1
Fuchs, S.Y.2
Chen, A.3
Tan, P.4
Gomez, C.5
Ronai, Z.6
Pan, Z.Q.7
-
66
-
-
18344391432
-
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
-
Zheng N., Schulman B.A., Song L., Miller J.J., Jeffrey P.D., Wang P., Chu C., Koepp D.M., Elledge S.J., Pagano M., et al. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature 2002, 416:703-709.
-
(2002)
Nature
, vol.416
, pp. 703-709
-
-
Zheng, N.1
Schulman, B.A.2
Song, L.3
Miller, J.J.4
Jeffrey, P.D.5
Wang, P.6
Chu, C.7
Koepp, D.M.8
Elledge, S.J.9
Pagano, M.10
-
67
-
-
0035312367
-
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain
-
Zhu Y., Romero M.I., Ghosh P., Ye Z., Charnay P., Rushing E.J., Marth J.D., Parada L.F. Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001, 15:859-876.
-
(2001)
Genes Dev.
, vol.15
, pp. 859-876
-
-
Zhu, Y.1
Romero, M.I.2
Ghosh, P.3
Ye, Z.4
Charnay, P.5
Rushing, E.J.6
Marth, J.D.7
Parada, L.F.8
-
68
-
-
23644443053
-
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
-
Zhu Y., Guignard F., Zhao D., Liu L., Burns D.K., Mason R.P., Messing A., Parada L.F. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 2005, 8:119-130.
-
(2005)
Cancer Cell
, vol.8
, pp. 119-130
-
-
Zhu, Y.1
Guignard, F.2
Zhao, D.3
Liu, L.4
Burns, D.K.5
Mason, R.P.6
Messing, A.7
Parada, L.F.8
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