The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans

Molecular and Cellular Biology

Volumn 30, Issue 9, 2010, Pages 2264-2279

  Phan, Vernon T ^a,c   Ding, Vivianne W ^a   Li, Fenglei ^b   Chalkley, Robert J ^b   Burlingame, Alma ^b   McCormick, Frank ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; GPB1 PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; IRA1 PROTEIN; IRA2 PROTEIN; NEUROFIBROMIN; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; DOWN REGULATION; ENZYME REGULATION; FUNGAL STRAIN; GENOTYPE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEOMICS; SACCHAROMYCES CEREVISIAE; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BLOOD PROTEINS; CELL LINE; DOWN-REGULATION; GENE SILENCING; GLUCOSE; GTPASE-ACTIVATING PROTEINS; HUMANS; MASS SPECTROMETRY; NEUROFIBROMIN 1; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITINATION;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 77950662360     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01450-08     Document Type: Article

References (45)

1. Angers, S., C. J. Thorpe, T. L. Biechele, S. J. Goldenberg, N. Zheng, M. J. MacCoss, and R. T. Moon. 2006. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat. Cell Biol. 8:348-357.
2. Bader, J. L. 1986. Neurofibromatosis and cancer. Ann. N. Y. Acad. Sci. 486:57-65.
3. Ballester, R., D. Marchuk, M. Boguski, A. Saulino, R. Letcher, M. Wigler, and F. Collins. 1990. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63:851-859. (Pubitemid 120035058)
4. Bissinger, P. H., R. Wieser, B. Hamilton, and H. Ruis. 1989. Control of Saccharomyces cerevisiae catalase T gene (CTT1) expression by nutrient supply via the RAS-cyclic AMP pathway. Mol. Cell. Biol. 9:1309-1315.
5. Boyer, M. J., D. H. Gutmann, F. S. Collins, and D. Bar-Sagi. 1994. Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP. Oncogene 9:349-357.
6. Cichowski, K., and T. Jacks. 2001. NF1 tumor suppressor gene function: narrowing the GAP. Cell 104:593-604. (Pubitemid 32201953)
7. Cichowski, K., S. Santiago, M. Jardim, B. W. Johnson, and T. Jacks. 2003. Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. Genes Dev. 17:449-454. (Pubitemid 36258759)
8. Colicelli, J. 2004. Human RAS superfamily proteins and related GTPases. Sci. STKE 2004:RE13.
9. Collins, S. R., K. M. Miller, N. L. Maas, A. Roguev, J. Fillingham, C. S. Chu, M. Schuldiner, M. Gebbia, J. Recht, M. Shales, H. Ding, H. Xu, J. Han, K. Ingvarsdottir, B. Cheng, B. Andrews, C. Boone, S. L. Berger, P. Hieter, Z. Zhang, G. W. Brown, C. J. Ingles, A. Emili, C. D. Allis, D. P. Toczyski, J. S. Weissman, J. F. Greenblatt, and N. J. Krogan. 2007. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature 446:806-810.
10. Colombo, S., P. Ma, L. Cauwenberg, J. Winderickx, M. Crauwels, A. Teunissen, D. Nauwelaers, J. H. de Winde, M. F. Gorwa, D. Colavizza, and J. M. Thevelein. 1998. Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae. EMBO J. 17:3326-3341. (Pubitemid 28279507)
11. Colombo, S., D. Ronchetti, J. M. Thevelein, J. Winderickx, and E. Martegani. 2004. Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae. J. Biol. Chem. 279:46715-46722.
12. D'Angelo, I., S. Welti, F. Bonneau, and K. Scheffzek. 2006. A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein. EMBO Rep. 7:174-179.
13. Gettemans, J., K. Meerschaert, J. Vandekerckhove, and V. De Corte. 2003. A kelch beta propeller featuring as a G beta structural mimic: reinventing the wheel? Sci. STKE 2003:PE27.
14. Ghaemmaghami, S., W. K. Huh, K. Bower, R. W. Howson, A. Belle, N. Dephoure, E. K. O'Shea, and J. S. Weissman. 2003. Global analysis of protein expression in yeast. Nature 425:737-741. (Pubitemid 37314318)
15. Harashima, T., S. Anderson, J. R. Yates III, and J. Heitman. 2006. The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol. Cell 22:819-830. (Pubitemid 43912470)
16. Harashima, T., and J. Heitman. 2002. The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol. Cell 10:163-173. (Pubitemid 34876570)
17. He, Y. J., C. M. McCall, J. Hu, Y. Zeng, and Y. Xiong. 2006. DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev. 20:2949-2954.
18. Imai, Y., A. Nakada, R. Hashida, Y. Sugita, T. Tanaka, G. Tsujimoto, K. Matsumoto, A. Akasawa, H. Saito, and T. Oshida. 2002. Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients. Biochem. Biophys. Res. Commun. 297:1282-1290.
19. Jin, J., E. E. Arias, J. Chen, J. W. Harper, and J. C. Walter. 2006. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol. Cell 23:709-721. (Pubitemid 44292562)
20. Johannessen, C. M., E. E. Reczek, M. F. James, H. Brems, E. Legius, and K. Cichowski. 2005. The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc. Natl. Acad. Sci. U. S. A. 102:8573-8578.
21. Kraakman, L., K. Lemaire, P. Ma, A. W. Teunissen, M. C. Donaton, P. Van Dijck, J. Winderickx, J. H. de Winde, and J. M. Thevelein. 1999. A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol. Microbiol. 32:1002-1012.
22. Longtine, M. S., A. McKenzie III, D. J. Demarini, N. G. Shah, A. Wach, A. Brachat, P. Philippsen, and J. R. Pringle. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14:953-961.
23. Magherini, F., S. Busti, T. Gamberi, E. Sacco, G. Raugei, G. Manao, G. Ramponi, A. Modesti, and M. Vanoni. 2006. In Saccharomyces cerevisiae an unbalanced level of tyrosine phosphorylation down-regulates the Ras/PKA pathway. Int. J. Biochem. Cell Biol. 38:444-460.
24. Mangoura, D., Y. Sun, C. Li, D. Singh, D. H. Gutmann, A. Flores, M. Ahmed, and G. Vallianatos. 2006. Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells. Oncogene 25:735-745. (Pubitemid 43214700)
25. Martin, G. A., D. Viskochil, G. Bollag, P. C. McCabe, W. J. Crosier, H. Haubruck, L. Conroy, R. Clark, P. O'Connell, R. M. Cawthon, et al. 1990. The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell 63:843-849.
26. Mueller, B., E. J. Klemm, E. Spooner, J. H. Claessen, and H. L. Ploegh. 2008. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc. Natl. Acad. Sci. U. S. A. 105:12325-12330.
27. Niranjan, T., X. Guo, J. Victor, A. Lu, and J. P. Hirsch. 2007. Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. J. Biol. Chem. 282:24231-24238.
28. Park, J. I., C. M. Grant, and I. W. Dawes. 2005. The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses. Biochem. Biophys. Res. Commun. 327:311-319.
29. Peeters, T., W. Louwet, R. Gelade, D. Nauwelaers, J. M. Thevelein, and M. Versele. 2006. Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc. Natl. Acad. Sci. U. S. A. 103:13034-13039.
30. Petroski, M. D., and R. J. Deshaies. 2005. Function and regulation of cullin- RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 6:9-20.
31. Rajalingam, K., C. Wunder, V. Brinkmann, Y. Churin, M. Hekman, C. Sievers, U. R. Rapp, and T. Rudel. 2005. Prohibitin is required for Rasinduced Raf-MEK-ERK activation and epithelial cell migration. Nat. Cell Biol. 7:837-843.
32. Riccardi, V. M. 1992. Type 1 neurofibromatosis and the pediatric patient. Curr. Probl. Pediatr. 22:66-107.
33. Rodriguez-Viciana, P., J. Oses-Prieto, A. Burlingame, M. Fried, and F. McCormick. 2006. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol. Cell 22:217-230.
34. Rudoni, S., S. Colombo, P. Coccetti, and E. Martegani. 2001. Role of guanine nucleotides in the regulation of the Ras/cAMP pathway in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1538:181-189.
35. Schubbert, S., K. Shannon, and G. Bollag. 2007. Hyperactive Ras in developmental disorders and cancer. Nat. Rev. Cancer 7:295-308.
36. Shirayama, M., K. Kawakami, Y. Matsui, K. Tanaka, and A. Toh-e. 1993. MSI3, a multicopy suppressor of mutants hyperactivated in the RAS-cAMP pathway, encodes a novel HSP70 protein of Saccharomyces cerevisiae. Mol. Gen. Genet. 240:323-332.
37. Tanaka, K., M. Nakafuku, T. Satoh, M. S. Marshall, J. B. Gibbs, K. Matsumoto, Y. Kaziro, and A. Toh-e. 1990. S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein. Cell 60:803-807. (Pubitemid 20086893)
38. Tanaka, K., M. Nakafuku, F. Tamanoi, Y. Kaziro, K. Matsumoto, and A. Toh-e. 1990. IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. Mol. Cell. Biol. 10:4303-4313.
39. Thevelein, J. M., and J. H. de Winde. 1999. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 33:904-918.
40. Toda, T., I. Uno, T. Ishikawa, S. Powers, T. Kataoka, D. Broek, S. Cameron, J. Broach, K. Matsumoto, and M. Wigler. 1985. In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 40:27-36.
41. Welcker, M., and B. E. Clurman. 2008. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat. Rev. Cancer 8:83-93.
42. Welti, S., S. Fraterman, I. D'Angelo, M. Wilm, and K. Scheffzek. 2007. The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex. J. Mol. Biol. 366: 551-562.
43. Xu, G. F., B. Lin, K. Tanaka, D. Dunn, D. Wood, R. Gesteland, R. White, R. Weiss, and F. Tamanoi. 1990. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 63:835-841.
44. Zeller, C. E., S. C. Parnell, and H. G. Dohlman. 2007. The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast. J. Biol. Chem. 282:25168-25176.
45. Zhu, Y., and L. F. Parada. 2001. Neurofibromin, a tumor suppressor in the nervous system. Exp. Cell Res. 264:19-28.