Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis

Genes to Cells

Volumn 8, Issue 11, 2003, Pages 857-872

  Sasagawa, Yohei ^a   Urano, Takeshi ^b   Kohara, Yuji ^c   Takahashi, Hideyuki ^a   Higashitani, Atsushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTE OF GENETICS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; HISTONE H3; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN RBX1; PROTEIN SUBUNIT; RNA; SERINE; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CAENORHABDITIS ELEGANS; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CHROMOSOME ABERRATION; CHROMOSOME CONDENSATION; CHROMOSOME SEGREGATION; CONTROLLED STUDY; CYTOKINESIS; DROSOPHILA MELANOGASTER; EMBRYO; EMBRYO CELL; GENETIC CONSERVATION; GERM CELL; GONAD; MEIOSIS; MITOSIS; MITOSIS INHIBITION; MULTINUCLEAR CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHASE TRANSITION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SPECIES DIFFERENTIATION; YEAST;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CARRIER PROTEINS; CELL DIVISION; CHROMOSOME SEGREGATION; CHROMOSOMES; EMBRYO; HISTONES; MEIOSIS; MITOSIS; MOLECULAR SEQUENCE DATA; PHENOTYPE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; RNA INTERFERENCE; SEQUENCE HOMOLOGY, AMINO ACID; ZINC FINGERS;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MELANOGASTER; NEMATODA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0242456201     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2003.00682.x     Document Type: Article

References (63)

1. Ahmed, S., Alpi, A., Hengartner, M.O. & Gartner, A. (2001) C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Curr. Biol. 11, 1934-1944.
2. Albertson, D.G. (1985) Mapping muscle protein genes by in situ hybridization using biotin-labeled probes. EMBO J. 4, 2493-2498.
3. Aoki, H., Sato, S., Takanami, T., et al. (2000) Characterization of Ce-atl-1, an ATM-like gene from Caenorhabditis elegans. Mol. Gen. Genet. 264, 119-126.
4. Banerjee, A., Gregori, L., Xu, Y. & Chau, V. (1993) The bacterially expressed yeast CDC34 gene product can undergo autoubiquitination to form a multiubiquitin chain-linked protein. J. Biol. Chem. 268, 5668-5675.
5. Beanan, M.J. & Strome, S. (1992) Characterization of a germ-line proliferation mutation in C. elegans. Development 116, 755-766.
6. Bischoff, J.R. & Plowman, G.D. (1999) The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol. 9, 454-459.
7. Boxem, M. & van den Heuvel, S. (2001) lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans. Development 128, 4349-4359.
8. Davis, E.S., Wille, L., Chestnut, B.A., Sadler, P.L., Shakes, D.C. & Golden, A. (2002) Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I. Genetics 160, 805-813.
9. Edgar, L.G. & McGhee, J.D. (1988) DNA synthesis and the control of embryonic gene expression in C. elegans. Cell 53, 589-599.
10. Feldman, R.M., Correll, C.C., Kaplan, K.B. & Deshaies, R.J. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91, 221-230.
11. Feng, H., Zhong, W., Punkosdy, G., et al. (1999) CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nature Cell Biol. 1, 486-492.
12. Files, J.G., Carr, S. & Hirsh, D. (1983) Actin gene family of Caenorhabditis elegans. J. Mol. Biol. 164, 355-375.
13. Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E. & Mello, C.C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811.
14. Fraser, A.G., Kamath, R.S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M. & Ahringer, J. (2000) Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408, 325-330.
15. Giet, R. & Glover, D.M. (2001) Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J. Cell Biol. 152, 669-682.
16. Glover, D.M., Leibowitz, M.H., McLean, D.A. & Parry, H. (1995) Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81, 95-105.
17. Gonczy, P., Echeverri, G., Oegema, K., et al. (2000) Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature 408, 331-336.
18. Goto, H., Tomono, Y., Ajiro, K., et al. (1999) Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. J. Biol. Chem. 274, 25543-25549.
19. 28 with regard to the mitotic chromosome condensation. Genes Cells 7, 11-17.
20. Hendzel, M.J., Wei, Y., Mancini, M.A., et al. (1997) Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106, 348-360.
21. Hershko, A., Heller, H., Elias, S. & Ciechanover, A. (1983) Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J. Biol. Chem. 258, 8206-8214.
22. Higashitani, A., Aoki, H., Mori, A., Sasagawa, Y., Takanami, T. & Takahashi, H. (2000) Caenorhabditis elegans Chk2-like gene is essential for meiosis but dispensable for DNA repair. FEBS Lett. 485, 35-39.
23. Hochstrasser, M. (1996) Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405-439.
24. Hsu, J.Y., Sun, Z.W., Li, X., et al. (2000) Mitotic phosphorylation of histone H3 is governed by Ipl1 /aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102, 279-291.
25. Jones, A.R. & Schedl, T. (1995) Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68. Genes Dev. 9, 1491-1504.
26. Kamath, R.S., Fraser, A.G., Dong, Y., et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421, 231-237.
27. Kamath, R.S., Martinez-Campos, M., Zipperlen, P., Fraser, A.G. & Ahringer, J. (2001) Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol. 2, RESEARCH0002 [Online].
28. Kamura, T., Conrad, M.N., Yan, Q., Conaway, R.C. & Conaway, J.W. (1999a) The Rbx1 subunit of SCF andVHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. Genes Dev. 13, 2928-2933.
29. Kamura, T., Koepp, D.M., Conrad, M.N., et al. (1999b) Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science 284, 657-661.
30. King, R.W., Deshaies, R.J., Peters, J.M. & Kirschner, M.W. (1996) How proteolysis drives the cell cycle. Science 274, 1652-1659.
31. Kipreos, E.T., Lander, L.E., Wing, J.P., He, W.W. & Hedgecock, E.M. (1996) cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85, 829-839.
32. Koepp, D.M., Harper, J.W. & Elledge, S.J. (1999) How the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell 97, 431-434.
33. Krek, W. (1998) Proteolysis and the G1-S transition: the SCF connection. Curr. Opin. Genet. Dev. 8, 36-42.
34. Kurz, T., Pintard, L., Willis, J.H., et al. (2002) Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science 295, 1294-1298.
35. Lewis, J.A. & Fleming, J.T. (1995) Basic culture methods. Meth. Cell Biol. 48, 3-29.
36. Maeda, I., Kohara, Y., Yamamoto, M. & Sugimoto, A. (2001) Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr. Biol. 11, 171-176.
37. Michael, W.M. & Newport, J. (1998) Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Wee1. Science 282, 1886-1889.
38. Nayak, S., Santiago, F.E., Jin, H., Lin, D., Schedl, T. & Kipreos, E.T. (2002) The Caenorhabditis elegans Skp1-related gene family. diverse functions in cell proliferation, morphogenesis, and meiosis. Curr. Biol. 12, 277-287.
39. Ohta, T., Michel, J.J., Schottelius, A.J. & Xiong, Y. (1999) ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol. Cell. 3, 535-541.
40. Park, M. & Krause, M.W. (1999) Regulation of postembryonic G (1) cell cycle progression in Caenorhabditis elegans by a cyclin D/CDK-like complex. Development 126, 4849-4860.
41. Peters, J.M. (1998) SCF and APC: the Yin and Yang of cell cycle regulated proteolysis. Curr. Opin. Cell Biol. 10, 759-768.
42. Piano, F., Schetter, A.J., Morton, D.G., et al. (2002) Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans. Curr. Biol. 12, 1959-1964.
43. Praitis, V., Casey, E., Collar, D. & Austin, J. (2001) Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. Genetics 157, 1217-1226.
44. Schumacher, J.M., Ashcroft, N., Donovan, P.J. & Golden, A. (1998a) A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos. Development 125, 4391-4402.
45. Schumacher, J.M., Golden, A. & Donovan, P.J. (1998b) AIR-2: An Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos. J. Cell Biol. 143, 1635-1646.
46. Schwob, E., Bohm, T., Mendenhall, M.D. & Nasmyth, K. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79, 233-244.
47. Seol, J.H., Feldman, R.M., Zachariae, W., et al. (1999) Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Genes Dev. 13, 1614-1626.
48. Seydoux, G. & Dunn, M.A. (1997) Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster. Development 124, 2191-2201.
49. Skowyra, D., Craig, K.L., Tyers, M., Elledge, S.J. & Harper, J.W. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209-219.
50. Skowyra, D., Koepp, D.M., Kamura, T., et al. (1999) Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science 284, 662-665.
51. Sugiyama, K., Sugiura, K., Hara, T., et al. (2002) Aurora-B associated protein phosphatases as negative regulators of kinase activation. Oncogene 21, 3103-3111.
52. Tabara, H., Grishok, A. & Mello, C.C. (1998) RNAi in C. elegans: soaking in the genome sequence. Science 282, 430-431.
53. Tabara, H., Motohashi, T. & Kohara, Y. (1996) A multi-well version of in situ hybridization on whole mount embryos of Caenorhabditis elegans. Nucl. Acids Res. 24, 2119-2124.
54. Takanami, T., Mori, A., Takahashi, H. & Higashitani, A. (2000) Hyper-resistance of meiotic cells to radiation due to a strong expression of a single recA-like gene in Caenorhabditis elegans. Nucl. Acids Res. 28, 4232-4236.
55. Takanami, T., Sato, S., Ishihara, T., Katsura, I., Takahashi, H. & Higashitani, A. (1998) Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination. DNA Res. 5, 373-377.
56. Tan, P., Fuchs, S.Y., Chen, A., et al. (1999) Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of IκBα. Mol. Cell. 3, 527-533.
57. Timmons, L. & Fire, A. (1998) Specific interference by ingested dsRNA. Nature 395, 854.
58. Tyers, M. & Jorgensen, P. (2000) Proteolysis and the cell cycle: with this RING I do thee destroy. Curr. Opin. Genet. Dev. 10, 54-64.
59. Wei, Y., Yu L., Bowen, J., Gorovsky, M.A. & Allis, C.D. (1999) Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell 97, 99-109.
60. Wei, Y., Mizzen, C.A., Cook, R.G., Gorovsky, M.A. & Allis, C.D. (1998) Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena. Proc. Natl. Acad. Sci. USA 95, 7480-7484.
61. Woollard, A. & Hodgkin, J. (1999) Stu-7/air-2 is a C. elegans aurora homologue essential for chromosome segregation during embryonic and post-embryonic development. Mech. Dev. 82, 95-108.
62. Zheng, N., Schulman, B.A., Song, L., et al. (2002) Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex. Nature 416, 703-709.
63. Zhong, W., Feng, H., Santiago, F.E. & Kipreos, E.T. (2003) CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature 423, 885-889.