Effect of excipients on PLGA film degradation and the stability of an incorporated peptide

Journal of Controlled Release

Volumn 117, Issue 3, 2007, Pages 413-420

  Houchin, M L ^a   Neuenswander, S A ^a   Topp, E M ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Basic salts; Peptide stability; pH modifiers; PLGA; Proton sponge

Indexed keywords

BASIC SALTS; PEPTIDE ACYLATION; PEPTIDE STABILITY; PH MODIFIERS; PROTON SPONGE;

ACYLATION; AMINO ACIDS; DEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; PH EFFECTS; SALTS; THERMOGRAVIMETRIC ANALYSIS;

POLYPEPTIDES;

1,8 BIS(DIMETHYLAMINO)NAPHTHALENE; AMINE; AMMONIUM ACETATE; BUFFER; EXCIPIENT; MAGNESIUM ACETATE; MAGNESIUM HYDROXIDE; PEPTIDE; POLYGLACTIN; UNCLASSIFIED DRUG; VALYLTYROSYLPROLYLASPARAGINYLGLYCYLALANINE;

ACYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DEAMINATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; FILM; GEL PERMEATION CHROMATOGRAPHY; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MONITORING; PH; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; THERMOGRAVIMETRY;

ACYLATION; BUFFERS; CALIBRATION; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG STORAGE; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MAGNESIUM HYDROXIDE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR WEIGHT; PEPTIDES; POLYGLYCOLIC ACID; POLYMERS; THERMOGRAVIMETRY; WATER;

EID: 33846799405     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.11.023     Document Type: Article

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