Formation of acylated growth hormone-releasing peptide-6 by poly(lactide-co-glycolide) and its biological activity

AAPS PharmSciTech

Volumn 8, Issue 2, 2007, Pages

  Na, Dong Hee ^a   Lee, Jeong Eun ^b   Jang, Sun Woo ^b   Lee, Kang Choon ^b  

^a Kyungsung University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

Growth hormone releasing peptide 6; Microspheres; Peptide acylation; Poly(lactide co glycolide); Stability

Indexed keywords

HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; MICROSPHERE; POLYGLACTIN; POLYMER; GROWTH HORMONE; GROWTH HORMONE RELEASING HEXAPEPTIDE; LACTIC ACID; OLIGOPEPTIDE; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEGRADATION; DRUG ACTIVITY; DRUG FORMULATION; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HYDROPHILICITY; IN VIVO STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SINGLE DRUG DOSE; SPRAGUE DAWLEY RAT; ANIMAL; CHEMISTRY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SECRETION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; GROWTH HORMONE; LACTIC ACID; MALE; MICROSPHERES; OLIGOPEPTIDES; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 34250671563     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt0802043     Document Type: Article

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