Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma

Head and Neck

Volumn 34, Issue 1, 2012, Pages 104-112

  Leovic, Dinko ^a   Sabol, Maja ^b   Ozretic, Petar ^b   Musani, Vesna ^b   Car, Diana ^b   Marjanovic, Ksenija ^a   Zubcic, Vedran ^a   Sabol, Ivan ^b   Sikora, Miroslav ^a   Grce, Magdalena ^b   Glavas Obrovac, Ljubica ^a   Levanat, Sonja ^b  

^a UNIVERSITY HOSPITAL OSIJEK   (Croatia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Hedgehog Gli signaling; oral cancer; squamous cell carcinoma; survivin

Indexed keywords

HEDGEHOG GLI PROTEIN; PROTEIN P16; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; CANCER STAGING; CHEEK MUCOSA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MOUTH CANCER; ORAL SQUAMOUS CELL CARCINOMA; OROPHARYNGEAL SQUAMOUS CELL CARCINOMA; OROPHARYNX CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOKING; SQUAMOUS CELL CARCINOMA; STROMA; TUMOR VOLUME;

ADULT; AGED; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL CULTURE TECHNIQUES; FEMALE; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MOUTH NEOPLASMS; OROPHARYNGEAL NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 83555161646     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.21696     Document Type: Article

References (43)

1. Warnakulasuriya S,. Global epidemology of oral and oropharyngeal cancer. Oral Oncol 2009; 45: 309-316.
2. Perez-Ordonez B, Beauchemin M, Jordan RCK,. Molecular biology of squamous cell carcinoma of head and neck. J Clin Pathol 2006; 59: 445-453.
3. Hall JM, Hooper JE, Finger TE,. Expression of Sonic Hedgehog, Patched and Gli1 in developing taste papillae of the mouse. J Comp Neurol 1999; 406: 143-155. (Pubitemid 29113830)
4. Gritli-Linde A, Bei M, Maas R, et al. Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 2002; 129: 5323-5237.
5. Jaskoll T, Leo T, Witcher D, et al. Sonic hedgehog signaling plays an essential role during embriogenic salivary gland epithelial branching morphogenesis. Dev Dyn 2004; 229: 722-732. (Pubitemid 38429101)
6. Watkins DN, Peacock CD,. Hedgehog signaling in foregut malignancy. Biochem Pharmacol 2004; 68: 1055-1060.
7. Cohen MM Jr,. The Hedgehog signaling network. Am J Med Genet 2003; 123A: 5-28. (Pubitemid 37309353)
8. Lauth M, Toftgard R,. Non-canonical activation of GLI transcription factors. Cell Cycle 2007; 6: 2458-2463.
9. Sah NK, Khan Z, Khan GJ, et al. Structural, functional and therapeutic biology of survivin. Cancer Lett 2006; 244: 164-171. (Pubitemid 44485888)
10. Nishimaki H, Kasai K, Kozaki K, et al. A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line. Biochem Biophys Res Comm 2004; 314: 313-320. (Pubitemid 38084719)
11. Schneider S, Thurnher D, Kloimstein P, et al. Expression of the Sonic hedgehog pathway in squamous cell carcinoma of the skin and mucosa of the head and neck. Head Neck 2010 [Epub ahead of print]
12. Greene FL, Page DL, Fleming ID, et al (editors). AJCC Cancer Staging Manual, 6th ed. New York: Springer; 2002.
13. Eichberger T, Sander V, Scnidar H, et al. Overlapping and distinct regulator properties of the GLI1 and GLI2 oncogenes. Genomics 2006; 87: 616-632.
14. Regl G, Neill GW, Eichberger T, et al. Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma. Oncogene 2002; 21: 5529-5539. (Pubitemid 34983542)
15. Kallassy M, Toftgard R, Ueda M, et al. Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin. Cancer Res 1997; 57: 4731-4735. (Pubitemid 27468977)
16. Bocker W, Yin Z, Drosse I, et al. Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral transfer. J Cell Mol Med 2008; 12: 1347-1359.
17. Song H, Xin X-Y, Xiao F, et al. Survivin gene RNA interference inhibits proliferation, induces apoptosis and enhances radiosensitivity in HeLa cells. Eur J Obstet Gynecol Reprod Biol 2006; 136: 83-89.
18. Hoffmann A-C, Warnecke-Eberz U, Luebke T, et al. Survivin mRNA in peripheral blood is frequently detected and significantly decreased following resection of gastrointestinal cancers. J Surg Oncol 2007; 95: 51-54. (Pubitemid 46122718)
19. Milutin-Gašperov N, Sabol I, Halec G, Matovina M, Grce M,. Retrospective study of the prevalence of high-risk human papillomaviruses among Croatian women. Coll Antropol 2007; 31: 89-96.
20. Forslund O, Antonsson A, Nordin P, Stenquist B, Goran Hansson B,. A broad range of human papillomavirus types detected with a general PCR method suitable for analysis of cutaneous tumours and normal skin. J General Virol 1999; 80: 2437.
21. Xuan YH, Jung HS, Choi Y-L, et al. Enhanced expression of hedgehog signaling molecules in squamous cell carcinoma of uterine cervix and its precursor lesions. Modern Pathol 2006; 19: 1139-1147. (Pubitemid 44106730)
22. Yauch RL, Gould SE, Scales SJ, et al. A paracrine requirement for hedgehog signalling in cancer. Nature Lett 2008; 455: 406-411.
23. Wang D, Grecula JC, Gahbauer RA, et al. P16 gene alterations in locally advanced squamous cell carcinoma of the head and neck. Oncol Rep 2006; 15: 661-665.
24. Cretnik M, Poje G, Musani V, et al. Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma. Int J Oncol 2009; 34: 1045-1050.
25. Duman-Scheel M, Weng L, Xin S, Du W,. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 2002; 417 (6886): 299-304. (Pubitemid 34534713)
26. Levanat S, Kappler R, Hemmerlein B, et al. Analysis of the PTCH1 signaling pathway in ovarian dermoids. Int J Mol Med 2004; 14: 793-799.
27. Ishiyama A, Hibi K, Koike M, et al. PTCH gene expression as a potential marker for esophageal squamous cell carcinoma. Anticancer Res 2006; 26: 195-198. (Pubitemid 43206078)
28. Fukuda S, Pelus LM,. Survivin, a cancer target with an emerging role in normal adult tissues. Mol Cancer Ther 2006; 5: 1087-1098. (Pubitemid 43881300)
29. Slaughter DP, Southwick HW,. Field cancerization in oral stratified squamous epithelium. Clinical implications of multicentric origin. Cancer 1953; 6: 963-968.
30. Riedel F, Goessler U, Hormann K,. Alcohol-related diseases of the mouth and throat. Best Practice Res Clin Gastroenterol 2003; 17: 543-555.
31. Proia NK, Paszkiewicz GM, Sullivan Nasca MA, et al. Smoking and smokeless tobacco-associated human buccal cell mutations and their association with oral cancer-a review. Cancer Epidemiol Biomarkers Prev 2006; 15: 1061-1077.
32. Herrero R,. Human Papillomavirus and Oral Cancer: The International Agency for Research on Cancer Multicenter Study. CancerSpectrum Knowledge Environment 2003; 95: 1772-1783. (Pubitemid 38008900)
33. Machado J, Reis PP, Zhang T, et al. Low prevalence of human papillomavirus in oral cavity carcinomas. Head Neck Oncol 2010; 2: 6.
34. Marur S, D'souza G, Westra WH, Forastiere AA,. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol 2010; 11: 781-789.
35. Le H, Kleinerman R, Lerman OZ, et al. Hedgehog signaling is required for normal wound healing. Wound Repair Regen 2008; 16: 768-773.
36. Zhou J-x, Jia L-w, Liu W-m, et al. Role of Sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis. Hum Reprod 2006; 21: 1698-1704. (Pubitemid 44028239)
37. Levanat S, PaveliÄ B, CrniÄ I, et al. Involvement of PTCH gene in various noninflammatory cysts. J Mol Med 2000; 78: 140-146. (Pubitemid 30337495)
38. Levanat S, Gorlin RJ, Fallet S, et al. A two-hit model for developmental defects in Gorlin syndrome. Nat Genet 1996; 12: 85-87. (Pubitemid 26011325)
39. Makowski GJ, McGuff S, Van Sickles JE,. Squamous cell carcinoma in a maxillary odontogenic keratocyst. J Oral Maxillofac Surg 2001; 59: 76-80. (Pubitemid 32051788)
40. Ma X, Sheng T, Zhang Y, et al. Hedgehog signaling is activated in subsets of esophageal cancers. Int J Cancer 2006; 118: 139-148. (Pubitemid 41681590)
41. Katoh Y, Katoh M,. Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med 2009; 9: 873-886.
42. Feldmann, G, Dhara S, Fendrich V, et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid tumors. Cancer Res 2007; 67: 2187-2196. (Pubitemid 46424238)
43. Ma X, Chen K, Huang S, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 2005; 26: 1698-1705. (Pubitemid 41487985)