-
2
-
-
41849122261
-
1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems
-
DOI 10.1021/jm7011563
-
A. Cappelli C. Nannicini A. Gallelli G. Giuliani S. Valenti G. la Pericot Mohr M. Anzini L. Mennuni F. Ferrari G. Caselli A. Giordani W. Peris F. Makovec G. Giorgi S. Vomero 2008 J. Med. Chem. 51 2137 10.1021/jm7011563 1:CAS:528:DC%2BD1cXislKqt7s%3D (Pubitemid 351503269)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.7
, pp. 2137-2146
-
-
Cappelli, A.1
Nannicini, C.2
Gallelli, A.3
Giuliani, G.4
Valenti, S.5
Mohr, G.P.6
Anzini, M.7
Mennuni, L.8
Ferrari, F.9
Caselli, G.10
Giordani, A.11
Peris, W.12
Makovec, F.13
Giorgi, G.14
Vomero, S.15
-
3
-
-
0036009870
-
Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase
-
DOI 10.1016/S0968-0896(02)00034-2, PII S0968089602000342
-
A. Straub J. Benet-Buchholz R. Froede A. Kern C. Kohlsdorfer P. Schmitt T. Schwarz H.-M. Siefert J.-P. Stasch 2002 Bioorg. Med. Chem. 10 1711 10.1016/S0968-0896(02)00034-2 1:CAS:528:DC%2BD38XisFWhtL4%3D (Pubitemid 34286364)
-
(2002)
Bioorganic and Medicinal Chemistry
, vol.10
, Issue.6
, pp. 1711-1717
-
-
Straub, A.1
Benet-Buckholz, J.2
Frode, R.3
Kern, A.4
Kohlsdorfer, C.5
Schmitt, P.6
Schwarz, T.7
Siefert, H.-M.8
Stasch, J.-P.9
-
4
-
-
0035952993
-
NO-independent stimulators of soluble guanylate cyclase
-
DOI 10.1016/S0960-894X(01)00073-7, PII S0960894X01000737
-
A. Straub J.-P. Stasch C. Alonso-Alija J. Benet-Buchholz B. Ducke A. Feurer C. Fuerstner 2001 Bioorg. Med. Chem. Lett. 11 781 10.1016/S0960-894X(01) 00073-7 1:CAS:528:DC%2BD3MXitVOjtLw%3D (Pubitemid 32230679)
-
(2001)
Bioorganic and Medicinal Chemistry Letters
, vol.11
, Issue.6
, pp. 781-784
-
-
Straub, A.1
Stasch, J.-P.2
Alonso-Alija, C.3
Benet-Buchholz, J.4
Ducke, B.5
Feurer, A.6
Furstner, C.7
-
5
-
-
54549125887
-
-
10.1021/jm800856c 1:CAS:528:DC%2BD1cXht1SjtrjE
-
T. J. Tucker J. T. Sisko R. M. Tynebor T. M. Williams P. J. Felock J. A. Flynn M.-T. Lai Y. Liang G. McGaughey M. Liu M. Miller G. Moyer V. Munshi R. PerlowPoehnelt S. Prasad J. C. Reid R. Sanchez M. Torrent J. P. Vacca B.-L. Wan Y. Yan 2008 J. Med. Chem. 51 6503 10.1021/jm800856c 1:CAS:528:DC%2BD1cXht1SjtrjE
-
(2008)
J. Med. Chem.
, vol.51
, pp. 6503
-
-
Tucker, T.J.1
Sisko, J.T.2
Tynebor, R.M.3
Williams, T.M.4
Felock, P.J.5
Flynn, J.A.6
Lai, M.-T.7
Liang, Y.8
McGaughey, G.9
Liu, M.10
Miller, M.11
Moyer, G.12
Munshi, V.13
Perlowpoehnelt, R.14
Prasad, S.15
Reid, J.C.16
Sanchez, R.17
Torrent, M.18
Vacca, J.P.19
Wan, B.-L.20
Yan, Y.21
more..
-
7
-
-
33846936007
-
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt
-
DOI 10.1016/j.bmc.2007.01.010, PII S0968089607000247
-
G.-D. Zhu J. Gong V. B. Gandhi K. Woods Y. Luo X. Liu R. Guan V. Klinghofer E. F. Johnson V. S. Stoll M. Mamo Q. Li S. H. Rosenberg V.L. Giranda 2007 Bioorg. Med. Chem. 15 2441 10.1016/j.bmc.2007.01.010 1:CAS:528: DC%2BD2sXhvVOqsbY%3D (Pubitemid 46240905)
-
(2007)
Bioorganic and Medicinal Chemistry
, vol.15
, Issue.6
, pp. 2441-2452
-
-
Zhu, G.-D.1
Gong, J.2
Gandhi, V.B.3
Woods, K.4
Luo, Y.5
Liu, X.6
Guan, R.7
Klinghofer, V.8
Johnson, E.F.9
Stoll, V.S.10
Mamo, M.11
Li, Q.12
Rosenberg, S.H.13
Giranda, V.L.14
-
8
-
-
34347387725
-
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents
-
DOI 10.1016/j.bmcl.2007.05.029, PII S0960894X07005823
-
R. Lin P. J. Connolly Y. Lu G. Chiu S. Li Y. Yu S. Huang X. Li S. L. Emanuel S. A. Middleton R. H. Gruninger M. Adams A. R. Fuentes-Pesquera L. M. Greenberger 2007 Bioorg. Med. Chem. Lett. 17 4297 10.1016/j.bmcl.2007.05.029 1:CAS:528:DC%2BD2sXnsVKnu7w%3D (Pubitemid 47021391)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.15
, pp. 4297-4302
-
-
Lin, R.1
Connolly, P.J.2
Lu, Y.3
Chiu, G.4
Li, S.5
Yu, Y.6
Huang, S.7
Li, X.8
Emanuel, S.L.9
Middleton, S.A.10
Gruninger, R.H.11
Adams, M.12
Fuentes-Pesquera, A.R.13
Greenberger, L.M.14
-
9
-
-
0037463754
-
1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases
-
DOI 10.1016/S0960-894X(03)00034-9
-
R. N. Misra D. B. Rawlins H.-y. Xiao W. Shan I. Bursuker K. A. Kellar J. G. Mulheron J. S. Sack J. S. Tokarski S. D. Kimball K. R. Webster 2003 Bioorg. Med. Chem. Lett. 13 1133 10.1016/S0960-894X(03)00034-9 1:CAS:528: DC%2BD3sXitFGksLY%3D (Pubitemid 36331816)
-
(2003)
Bioorganic and Medicinal Chemistry Letters
, vol.13
, Issue.6
, pp. 1133-1136
-
-
Misra, R.N.1
Rawlins, D.B.2
Xiao, H.-Y.3
Shan, W.4
Bursuker, I.5
Kellar, K.A.6
Mulheron, J.G.7
Sack, J.S.8
Tokarski, J.S.9
Kimball, S.D.10
Webster, K.R.11
-
10
-
-
12444260278
-
1H-pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: Highly potent 2,6-difluorophenacyl analogues
-
DOI 10.1016/S0960-894X(03)00381-0
-
R. N. Misra H.-y. Xiao D. B. Rawlins W. Shan K. A. Kellar J. G. Mulheron J. S. Sack J. S. Tokarski S. D. Kimball K. R. Webster 2003 Bioorg. Med. Chem. Lett. 13 2405 10.1016/S0960-894X(03)00381-0 1:CAS:528:DC%2BD3sXkvVGqsr4%3D (Pubitemid 36724992)
-
(2003)
Bioorganic and Medicinal Chemistry Letters
, vol.13
, Issue.14
, pp. 2405-2408
-
-
Misra, R.N.1
Xiao, H.-Y.2
Rawlins, D.B.3
Shan, W.4
Kellar, K.A.5
Mulheron, J.G.6
Sack, J.S.7
Tokarski, J.S.8
Kimball, S.D.9
Webster, K.R.10
-
11
-
-
48649108824
-
-
10.1016/j.bmc.2008.06.042 1:CAS:528:DC%2BD1cXps12jt78%3D
-
S. B. Bharate T. R. Mahajan Y. R. Gole M. Nambiar T. T. Matan A. Kulkarni-Almeida S. Balachandran H. Junjappa A. Balakrishnan R. A. Vishwakarma 2008 Bioorg. Med. Chem. 16 7167 10.1016/j.bmc.2008.06.042 1:CAS:528: DC%2BD1cXps12jt78%3D
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 7167
-
-
Bharate, S.B.1
Mahajan, T.R.2
Gole, Y.R.3
Nambiar, M.4
Matan, T.T.5
Kulkarni-Almeida, A.6
Balachandran, S.7
Junjappa, H.8
Balakrishnan, A.9
Vishwakarma, R.A.10
-
12
-
-
47149103616
-
-
10.1016/j.bmcl.2008.05.052 1:CAS:528:DC%2BD1cXoslCjt7Y%3D
-
J. N. Hamblin T. D. R. Angell S. P. Ballantine C. M. Cook A. W. J. Cooper J. Dawson C. J. Delves P. S. Jones M. Lindvall F. S. Lucas C. J. Mitchell M. Y. Neu L. E. Ranshaw Y. E. Solanke D. O. Somers J. O. Wiseman 2008 Bioorg. Med. Chem. Lett. 18 4237 10.1016/j.bmcl.2008.05.052 1:CAS:528:DC%2BD1cXoslCjt7Y%3D
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 4237
-
-
Hamblin, J.N.1
Angell, T.D.R.2
Ballantine, S.P.3
Cook, C.M.4
Cooper, A.W.J.5
Dawson, J.6
Delves, C.J.7
Jones, P.S.8
Lindvall, M.9
Lucas, F.S.10
Mitchell, C.J.11
Neu, M.Y.12
Ranshaw, L.E.13
Solanke, Y.E.14
Somers, D.O.15
Wiseman, J.O.16
-
13
-
-
50349087353
-
-
10.1016/j.bmc.2008.07.035 1:CAS:528:DC%2BD1cXhtVyktbbM
-
B. Leal I. F. Afonso C. R. Rodrigues P. A. Abreu R. Garrett L. C. S. Pinheiro A. R. Azevedo J. C. Borges P. F. Vegi C. C. C. Santos F. C. A. d. Silveira L. M. Cabral I. C. P. P. Frugulhetti A. M. R. Bernardino D. O. Santos H. C. Castro 2008 Bioorg. Med. Chem. 16 8196 10.1016/j.bmc.2008.07.035 1:CAS:528:DC%2BD1cXhtVyktbbM
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 8196
-
-
Leal, B.1
Afonso, I.F.2
Rodrigues, C.R.3
Abreu, P.A.4
Garrett, R.5
Pinheiro, L.C.S.6
Azevedo, A.R.7
Borges, J.C.8
Vegi, P.F.9
Santos, C.C.C.10
Cabral, L.M.11
Frugulhetti, I.C.P.P.12
Bernardino, A.M.R.13
Santos, D.O.14
Castro, H.C.15
-
14
-
-
33751104210
-
Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series
-
DOI 10.1016/j.bmc.2006.09.067, PII S0968089606008157
-
L. R. S. Dias M. B. Santos S. d. Albuquerque H. C. Castro A. M. T. d. Souza A. C. C. Freitas M. A. V. DiVaio L. M. Cabral C. R. Rodrigues 2007 Bioorg. Med. Chem. 15 211 10.1016/j.bmc.2006.09.067 1:CAS:528:DC%2BD28Xht1CmtrbJ (Pubitemid 44767993)
-
(2007)
Bioorganic and Medicinal Chemistry
, vol.15
, Issue.1
, pp. 211-219
-
-
Dias, L.R.S.1
Santos, M.B.2
Albuquerque, S.D.3
Castro, H.C.4
De Souza, A.M.T.5
Freitas, A.C.C.6
DiVaio, M.A.V.7
Cabral, L.M.8
Rodrigues, C.R.9
-
15
-
-
63449123783
-
-
V. O. Iaroshenko, D. V. Sevenard, A. Kotljarov, D. M. Volochnyuk, A. O. Tolmachev, V. Ya. Sosnovskikh, Synthesis, 2009, 731.
-
(2009)
Synthesis
, pp. 731
-
-
Iaroshenko, V.O.1
Sevenard, D.V.2
Kotljarov, A.3
Volochnyuk, D.M.4
Tolmachev, A.O.5
Ya. Sosnovskikh, V.6
-
20
-
-
0042243695
-
-
D. M. Volochnyuk, A. O. Pushechnikov, D. G. Krotko, D. A. Sibgatulin, S. A. Kovalyova, A. A. Tolmachev, Synthesis, 2003, 1531
-
(2003)
Synthesis
, pp. 1531
-
-
Volochnyuk, D.M.1
Pushechnikov, A.O.2
Krotko, D.G.3
Sibgatulin, D.A.4
Kovalyova, S.A.5
Tolmachev, A.A.6
-
25
-
-
3242742372
-
-
1:CAS:528:DyaL2cXlvFWktLY%3D
-
R. Balicki 1983 Pol. J. Chem. 57 413 1:CAS:528:DyaL2cXlvFWktLY%3D
-
(1983)
Pol. J. Chem.
, vol.57
, pp. 413
-
-
Balicki, R.1
-
30
-
-
0034920040
-
Synthesis and reactivity of halogeno-difluoromethyl aromatics and heterocycles: Application to the synthesis of gem-difluorinated bioactive compounds
-
DOI 10.1016/S0022-1139(01)00378-5, PII S0022113901003785
-
C. Burkholder W. R. Dolbier Jr. M. Medebielle 2001 J. Fluorine Chem. 109 39 10.1016/S0022-1139(01)00378-5 1:CAS:528:DC%2BD3MXksFKlur0%3D (Pubitemid 33618189)
-
(2001)
Journal of Fluorine Chemistry
, vol.109
, Issue.1
, pp. 39-48
-
-
Burkholder, C.R.1
Dolbier Jr., W.R.2
Medebielle, M.3
-
32
-
-
0035111036
-
New antifungal 1,2,4-triazoles with difluoro(substituted sulfonyl)methyl moiety
-
DOI 10.1248/cpb.49.173
-
H. Eto Y. Kaneko S. Takeda M. Tokizawa S. Sato K. Yoshida S. Namiki M. Ogawa K. Maebashi K. Ishida M. Matsumoto T. Asaoka 2001 Chem. Pharm. Bull. 49 2, 173 10.1248/cpb.49.173 (Pubitemid 32174652)
-
(2001)
Chemical and Pharmaceutical Bulletin
, vol.49
, Issue.2
, pp. 173-182
-
-
Eto, H.1
Kaneko, Y.2
Takeda, S.3
Tokizawa, M.4
Sato, S.5
Yoshida, K.6
Namiki, S.7
Ogawa, M.8
Maebashi, K.9
Ishida, K.10
Matsumoto, M.11
Asaoka, T.12
-
33
-
-
23244460976
-
Syntheses of new difluoromethylene benzoxazole and 1,2,4-oxadiazole derivatives, as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
-
DOI 10.1016/j.jfluchem.2004.12.016, PII S0022113905000163, A Special Issue in Honour of Professor Richard D. Chambers on the occasion of his 70th Birthday
-
M. Medebielle S. Ait-Mohand C. Burkholder W. R. Dolbier Jr. G. Laumond A.-M. Aubertin 2005 J. Fluorine Chem. 126 535 10.1016/j.jfluchem.2004.12.016 1:CAS:528:DC%2BD2MXltlOks7Y%3D (Pubitemid 41094524)
-
(2005)
Journal of Fluorine Chemistry
, vol.126
, Issue.4
, pp. 535-542
-
-
Medebielle, M.1
Ait-Mohand, S.2
Burkhloder, C.3
Dolbier Jr., W.R.4
Laumond, G.5
Aubertin, A.-M.6
-
34
-
-
41849149691
-
PTP1B inhibitors: Synthesis and evaluation of difluoro- methylenephosphonate bioisosteres on a sulfonamide scaffold
-
DOI 10.1016/j.bmcl.2008.03.007, PII S0960894X08002709
-
C. P. Holmes X. Li Y. Pan C. Xu A. Bhandari C. M. Moody J. A. Miguel S. W. Ferla M. N. De Francisco B. T. Frederick S. Zhou N. Macher L. Jang J. D. Irvine J. R. Grove 2008 Bioorg. Med. Chem. Lett. 18 2719 10.1016/j.bmcl.2008.03. 007 1:CAS:528:DC%2BD1cXks1aktb0%3D (Pubitemid 351503868)
-
(2008)
Bioorganic and Medicinal Chemistry Letters
, vol.18
, Issue.8
, pp. 2719-2724
-
-
Holmes, C.P.1
Li, X.2
Pan, Y.3
Xu, C.4
Bhandari, A.5
Moody, C.M.6
Miguel, J.A.7
Ferla, S.W.8
De Francisco, M.N.9
Frederick, B.T.10
Zhou, S.11
Macher, N.12
Jang, L.13
Irvine, J.D.14
Grove, J.R.15
-
35
-
-
23644432990
-
Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors
-
DOI 10.1016/j.bmcl.2005.06.027, PII S0960894X05007651
-
K. Lee S. K. Boovanahalli K.-Y. Nam S.-U. Kang M. Lee J. Phan L. Wu D. S. Waugh Z.-Y. Zhang K. T. No J. J. Lee T. R. Burke Jr. 2005 Bioorg. Med. Chem. Lett. 15 4037 10.1016/j.bmcl.2005.06.027 1:CAS:528:DC%2BD2MXns1SgtrY%3D (Pubitemid 41132657)
-
(2005)
Bioorganic and Medicinal Chemistry Letters
, vol.15
, Issue.18
, pp. 4037-4042
-
-
Lee, K.1
Boovanahalli, S.K.2
Nam, K.-Y.3
Kang, S.-U.4
Lee, M.5
Phan, J.6
Wu, L.7
Waugh, D.S.8
Zhang, Z.-Y.9
Kyoung, T.N.10
Jung, J.L.11
Burke Jr., T.R.12
-
37
-
-
33846388809
-
Studies on a three-step preparation of β-fluoroalkyl acrylates from fluoroacetic esters
-
DOI 10.1016/j.tet.2006.12.045, PII S0040402006020102
-
M. Jagodzinska F. Huguenot M. Zanda 2007 Tetrahedron 63 2042 10.1016/j.tet.2006.12.045 1:CAS:528:DC%2BD2sXht1ajsLk%3D (Pubitemid 46136359)
-
(2007)
Tetrahedron
, vol.63
, Issue.9
, pp. 2042-2046
-
-
Jagodzinska, M.1
Huguenot, F.2
Zanda, M.3
-
39
-
-
33646684000
-
Purification, biological activities, and molecular cloning of a novel mannose-binding lectin from bulbs of Zephyranthes candida Herb (Amaryllidaceae)
-
DOI 10.1016/j.jfluchem.2005.10.015
-
Y.-M. Wu Y. Li J. Deng 2006 J. Fluorine Chem. 127 223 10.1016/j.jfluchem.2005.10.015 1:CAS:528:DC%2BD28Xht1ylt7s%3D (Pubitemid 43740577)
-
(2006)
Journal of Integrative Plant Biology
, vol.48
, Issue.2
, pp. 223-231
-
-
Wu, C.-F.1
Li, J.2
An, J.3
Chang, L.-Q.4
Chen, F.5
Bao, J.-K.6
-
42
-
-
83455261712
-
-
A. S. Golubev, V. O. Bogomolov, A. F. Shidlovskii, L. G. Dezhenkova, A. S. Peregudov, A. A. Shtil', N. D. Chkanikov, Izv. Akad. Nauk, Ser. Khim., 2010, 205
-
(2010)
Izv. Akad. Nauk, Ser. Khim.
, pp. 205
-
-
Golubev, A.S.1
Bogomolov, V.O.2
Shidlovskii, A.F.3
Dezhenkova, L.G.4
Peregudov, A.S.5
Shtil, A.A.6
Chkanikov, N.D.7
-
44
-
-
64549085357
-
-
10.1021/jm801335z 1:CAS:528:DC%2BD1MXisl2kur8%3D
-
A. Maiti P. V. N. Reddy M. Sturdy L. Marler S. D. Pegan A. D. Mesecar J. M. Pezzuto M. Cushman 2009 J. Med. Chem. 52 1873 10.1021/jm801335z 1:CAS:528:DC%2BD1MXisl2kur8%3D
-
(2009)
J. Med. Chem.
, vol.52
, pp. 1873
-
-
Maiti, A.1
Reddy, P.V.N.2
Sturdy, M.3
Marler, L.4
Pegan, S.D.5
Mesecar, A.D.6
Pezzuto, J.M.7
Cushman, M.8
-
50
-
-
37549039510
-
-
1:CAS:528:DC%2BD2sXhsVGhurzO
-
G. M. Sheldrick 2008 Acta Crystallogr. A64 112 1:CAS:528: DC%2BD2sXhsVGhurzO
-
(2008)
Acta Crystallogr.
, vol.64
, pp. 112
-
-
Sheldrick, G.M.1
-
51
-
-
37049074883
-
-
Y. Takeuchi, M. Asahina, K. Hori, T. Koizumi, J. Chem. Soc., Perkin Trans. 1, 1988, 1149.
-
(1988)
J. Chem. Soc., Perkin Trans.1
, pp. 1149
-
-
Takeuchi, Y.1
Asahina, M.2
Hori, K.3
Koizumi, T.4
-
54
-
-
83455228129
-
-
I. L. Knunyants, F. M. Mukhametshin, L. S. German, N. I. Delyagina, G. G. Korovushkin, Izv. Akad. Nauk SSSR, Ser. Khim., 1985, 1435
-
(1985)
Izv. Akad. Nauk SSSR, Ser. Khim.
, pp. 1435
-
-
Knunyants, I.L.1
Mukhametshin, F.M.2
German, L.S.3
Delyagina, N.I.4
Korovushkin, G.G.5
-
56
-
-
0035855340
-
Reformatsky-type aldol reactions of 4-bromo-4,4-difluoroacetoacetate with aldehydes and ketones
-
DOI 10.1016/S0040-4039(01)01106-6, PII S0040403901011066
-
Y. Wang S. Zhu 2001 Tetrahedron Lett. 42 5741 10.1016/S0040-4039(01) 01106-6 1:CAS:528:DC%2BD3MXlsFOlt7c%3D (Pubitemid 32710086)
-
(2001)
Tetrahedron Letters
, vol.42
, Issue.33
, pp. 5741-5744
-
-
Wang, Y.1
Zhu, S.2
-
57
-
-
0037212978
-
Synthesis of 2-benzyl-2H-pyrazole-3,4-diamine dihydrochloride
-
DOI 10.1016/S0040-4039(02)02527-3, PII S0040403902025273
-
M. H. Holschbach W. Wutz R. A. Olsson 2003 Tetrahedron Lett. 44 41 10.1016/S0040-4039(02)02527-3 1:CAS:528:DC%2BD38XpsVegur8%3D (Pubitemid 35453848)
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(2003)
Tetrahedron Letters
, vol.44
, Issue.1
, pp. 41-43
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Holschbach, M.H.1
Wutz, W.2
Olsson, R.A.3
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