Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-α and IL-6 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7167-7176

  Bharate, Sandip B ^a   Mahajan, Tushar R ^a   Gole, Yogesh R ^a   Nambiar, Mahesh ^a   Matan, T T ^a   Kulkarni Almeida, Asha ^a   Balachandran, Sarala ^a   Junjappa, H ^a   Balakrishnan, Arun ^a   Vishwakarma, Ram A ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

Anti inflammatory; IL 6; Pyrazolo 3,4 b pyridines; TNF

Indexed keywords

3 (2 HYDROXY 5 METHYLBENZOYL)BENZIMIDAZO[1,2 A]PYRIMIDINE; 3 PROPYL 3 OL BENZO[4,5]IMIDAZO[1,2 A]PYRIMIDINE; 5 (1 ETHOXY 2,4 DIMETHOXYLBUTYL 3 OL) 3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 (1 ETHOXY 2,4 DIMETHOXYLBUTYL 3 OL) 3 METHYL 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 (1 ETHOXYBUTYL 2,3,4 TRIOL) 3 (4 HYDROXY PHENYL) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 (1,2,4 TRIMETHOXYLBUTYL 3 OL) 1,3 DIMETHYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 (2 HYDROXY 3,5 DIMETHYLBENZOYL) 3 METHYL 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 (2 HYDROXY 5 FLUOROBENZOYL) 1,3 DIMETHYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 (2 HYDROXY 5 METHYLBENZOYL) 1,3 DIMETHYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 (2 HYDROXY 5 METHYLBENZOYL) 3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 (2 HYDROXY 5 METHYLBENZOYL) 3 METHYL 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 (2 HYDROXY 5 METHYLBENZOYL) 3 METHYLISOXAZOLO[5,4 B]PYRIDINE; 5 (2 HYDROXY 5 METHYLBENZOYL) 3 PHENYLISOXAZOLO[5,4 B]PYRIDINE; 5 (3 ACETOXY)PROPYL 1 ETHYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 PROPYL 3 OL 1,3 DIMETHYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 PROPYL 3 OL 3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 5 PROPYL 3 OL 3 METHYL 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE; 6 (1,2,4 TRIMETHOXYBUTYL 3 OL) 2 4 TOLYLPYRAZOLO[1,5 A]PYRIMIDINE; 6 (2 HYDROXY 5 METHYLBENZOYL) 2 4 TOLYLPYRAZOLO[1,5 A]PYRIMIDINE; 6 (2 HYDROXY 5 METHYLBENZOYL)PYRIDO[2,3 D]PYRIMIDINE 2,4 (1H,3H)DIONE; 6 (3 ACETOXY)PROPYLPYRAZOLO[1,5 A]PYRIMIDINE; 6 (3 ACETOXYPROPYL)[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 6 (3 HYDROXYPROPYL)PYRIDO[2,3 D]PYRIMIDINE 2,4 (1H,3H)DIONE; 6 PROPYL 3 OL 2 4 TOLYLPYRAZOLO[1,5 A]PYRIMIDINE; CYTOKINE RECEPTOR ANTAGONIST; DEXAMETHASONE; INTERLEUKIN 6 INHIBITOR; PYRAZOLO[3,4 B]PYRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; ONE POT SYNTHESIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTERLEUKIN-6; MOLECULAR STRUCTURE; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 48649108824     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.042     Document Type: Article

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