Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 8196-8204

  Leal, Bruno ^a   Afonso, Ilídio F ^b   Rodrigues, Carlos R ^b   Abreu, Paula A ^a   Garrett, Rafael ^a   Pinheiro, Luiz Carlos S ^a   Azevedo, Alexandre R ^a   Borges, Julio C ^a   Vegi, Percilene F ^a   Santos, Cláudio C C ^c   da Silveira, Francisco C A ^a   Cabral, Lúcio M ^b   Frugulhetti, Izabel C P P ^a   Bernardino, Alice M R ^a   Santos, Dilvani O ^a   Castro, Helena C ^a  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Fundacao Ataulpho de Paiva   (Brazil)

Author keywords

Antibacterial activity; Antimicrobial activity; In silico ADMET screening; MIC; Pyrazolopyridine; Staphylococcus epidermidis; Structure activity relationship (SAR)

Indexed keywords

1H PYRAZOLO[3,4 B]PYRIDINE; 4 (3' BROMOPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' BROMOPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' CHLOROPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' CHLOROPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' FLUOROPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' FLUOROPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' METHOXYPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' METHOXYPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' METHYLPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' METHYLPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' NITROPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (3' NITROPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (4' BROMOPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (4' CHLOROPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (4' FLUOROPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (4' METHOXYPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (4' METHOXYPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (4' METHYLPHENYLAMINO) 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (4' NITROPHENYLAMINO) 1 PHENYL 1H-PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; 4 (4' NITROPHENYLAMINO)THIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID; 4 PHENYLAMINO 1 PHENYL 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; CHLORAMPHENICOL; OXACILLIN; PYRIDINE DERIVATIVE; THIENO[2,3 B]PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTI-BACTERIAL AGENTS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, BACTERIAL; HUMANS; LEUKOCYTES, MONONUCLEAR; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PYRAZOLES; PYRIDINES; REFERENCE VALUES; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

STAPHYLOCOCCUS EPIDERMIDIS;

EID: 50349087353     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.035     Document Type: Article

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