Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo

FEBS Letters

Volumn 585, Issue 19, 2011, Pages 3120-3125

  Lin, Cuihong ^a,b   Lu, Wenyan ^a   Zhai, Ling ^a   Bethea, Traci ^a   Berry, Kristy ^a   Qu, Zhican ^a   Waud, William R ^a   Li, Yonghe ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Low density lipoprotein receptor related protein 5 6; Mesd; Prostate cancer; Wnt; Wnt signaling

Indexed keywords

BETA CATENIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; PROTEIN MESD; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; ENZYME REPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; CELL LINE, TUMOR; HEK293 CELLS; HUMANS; LIGANDS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MALE; MICE; MOLECULAR CHAPERONES; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; WNT PROTEINS;

EID: 80053276370     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.08.046     Document Type: Article

References (31)

1. B.T. MacDonald, K. Tamai, and X. He Wnt/beta-catenin signaling: components, mechanisms, and diseases Dev. Cell 17 2009 9 26
2. J. Culi, and R.S. Mann Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila Cell 112 2003 343 354 (Pubitemid 36187420)
3. J.C. Hsieh, L. Lee, L. Zhang, S. Wefer, K. Brown, C. DeRossi, M.E. Wines, T. Rosenquist, and B.C. Holdener Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity Cell 112 2003 355 367 (Pubitemid 36183655)
4. J. Culi, T.A. Springer, and R.S. Mann Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins EMBO J. 23 2004 1372 1380 (Pubitemid 38525008)
5. Y. Li, J. Chen, W. Lu, L.M. McCormick, J. Wang, and G. Bu Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding J. Cell Sci. 118 2005 5305 5314 (Pubitemid 41819592)
6. V. Koduri, and S.C. Blacklow Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation Biochemistry 46 2007 6570 6577 (Pubitemid 46870122)
7. Y. Li, W. Lu, X. He, and G. Bu Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd FEBS Lett. 580 2006 5423 5428 (Pubitemid 44415822)
8. W. Lu, C.C. Liu, J.V. Thottassery, G. Bu, and Y. Li Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells Biochemistry 49 2010 4635 4643
9. A. Kikuchi, H. Yamamoto, and S. Kishida Multiplicity of the interactions of Wnt proteins and their receptors Cell. Signal. 19 2007 659 671 (Pubitemid 46275377)
10. E. Bourhis, C. Tam, Y. Franke, J.F. Bazan, J. Ernst, J. Hwang, M. Costa, A.G. Cochran, and R.N. Hannoush Reconstitution of a frizzled8 · Wnt3a · LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6 J. Biol. Chem. 285 2010 9172 9179
11. S.A. Ettenberg, O. Charlat, M.P. Daley, S. Liu, K.J. Vincent, D.D. Stuart, A.G. Schuller, J. Yuan, B. Ospina, J. Green, Q. Yu, R. Walsh, S. Li, R. Schmitz, H. Heine, S. Bilic, L. Ostrom, R. Mosher, K.F. Hartlepp, Z. Zhu, S. Fawell, Y.M. Yao, D. Stover, P.M. Finan, J.A. Porter, W.R. Sellers, I.M. Klagge, and F. Cong Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies Proc. Natl. Acad. Sci. USA 107 2010 15473 15478
12. Y. Gong, E. Bourhis, C. Chiu, S. Stawicki, V.I. DeAlmeida, B.Y. Liu, K. Phamluong, T.C. Cao, R.A. Carano, J.A. Ernst, M. Solloway, B. Rubinfeld, R.N. Hannoush, Y. Wu, P. Polakis, and M. Costa Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies PLoS ONE 5 2010 e12682
13. 2+ and receptor-associated protein are independently required for proper folding and disulfide bond formation of the low density lipoprotein receptor-related protein J. Biol. Chem. 273 1998 22374 22381 (Pubitemid 28399799)
14. A. Bafico, A. Gazit, S.S. Wu-Morgan, A. Yaniv, and S.A. Aaronson Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts Oncogene 16 1998 2819 2825 (Pubitemid 28279349)
15. G. Chen, N. Shukeir, A. Potti, K. Sircar, A. Aprikian, D. Goltzman, and S.A. Rabbani Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications Cancer 101 2004 1345 1356 (Pubitemid 39180390)
16. C.C. Liu, C. Pearson, and G. Bu Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains J. Biol. Chem. 284 2009 15299 15307
17. P. Wend, J.D. Holland, U. Ziebold, and W. Birchmeier Wnt signaling in stem and cancer stem cells Semin. Cell Dev. Biol. 21 2010 855 863
18. M. Verras, and Z. Sun Roles and regulation of Wnt signaling and β-catenin in prostate cancer Cancer Lett. 237 2006 22 32
19. N. Barker, and H. Clevers Mining the Wnt pathway for cancer therapeutics Nat. Rev. Drug Discov. 5 2006 997 1014 (Pubitemid 44835127)
20. S. Gupta, K. Iljin, H. Sara, J.P. Mpindi, T. Mirtti, P. Vainio, J. Rantala, K. Alanen, M. Nees, and O. Kallioniemi FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells Cancer Res. 70 2010 6735 6745
21. V.L. Costa, R. Henrique, F.R. Ribeiro, J.R. Carvalho, J. Oliveira, F. Lobo, M.R. Teixeira, and C. Jerónimo Epigenetic regulation of Wnt signaling pathway in urological cancer Epigenetics 16 2010 343 351
22. C. Wissmann, P.J. Wild, S. Kaiser, S. Roepcke, R. Stoehr, M. Woenckhaus, G. Kristiansen, J.C. Hsieh, F. Hofstaedter, A. Hartmann, R. Knuechel, A. Rosenthal, and C. Pilarsky WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer J. Pathol. 201 2003 204 212 (Pubitemid 37258931)
23. M. Verras, J. Brown, X. Li, R. Nusse, and Z. Sun Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells Cancer Res. 64 2004 8860 8866 (Pubitemid 39665490)
24. W. Lu, H.N. Tinsley, A. Keeton, Z. Qu, G.A. Piazza, and Y. Li Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation Eur. J. Pharmacol. 602 2009 8 14
25. D.S. Yee, Y. Tang, X. Li, Z. Liu, Y. Guo, S. Ghaffar, P. McQueen, D. Atreya, J. Xie, A.R. Simoneau, B.H. Hoang, and X. Zi The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition Mol. Cancer 9 2010 162
26. Y. Li, and G. Bu LRP5/6 in Wnt signaling and tumorigenesis Future Oncol. 1 2005 673 681
27. C. Lindvall, N.C. Evans, C.R. Zylstra, Y. Li, C.M. Alexander, and B.O. Williams The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis J. Biol. Chem. 281 2006 35081 35087 (Pubitemid 46036547)
28. J. Zhang, Y. Li, Q. Liu, W. Lu, and G. Bu Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis Oncogene 29 2010 539 549
29. B.H. Hoang, T. Kubo, J.H. Healey, R. Yang, S.S. Nathan, E.A. Kolb, B. Mazza, P.A. Meyers, and R. Gorlick Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway Cancer Res. 64 2004 2734 2739 (Pubitemid 38500609)
30. X. Zi, Y. Guo, A.R. Simoneau, C. Hope, J. Xie, R.F. Holcombe, and B.H. Hoang Expression of Frzb/secreted frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness Cancer Res. 65 2005 9762 9770 (Pubitemid 41541453)
31. C.C. Liu, J. Prior, D. Piwnica-Worms, and G. Bu LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy Proc. Natl. Acad. Sci. USA 107 2010 5136 5141