FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Graham, Kathryn ^a   Moran Jones, Kim ^a   Sansom, Owen J ^a   Brunton, Valerie G ^b   Frame, Margaret C ^b  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; INTEGRIN; PROTEIN P21; PROTEIN P53; CYCLIN DEPENDENT KINASE INHIBITOR 1A;

ADVANCED CANCER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FEMALE; FOCAL ADHESION KINASE GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; IONIZING RADIATION; MOUSE; NONHUMAN; ONCOGENE; P21 GENE; PROTEIN FUNCTION; PROTEIN INDUCTION; RADIOSENSITIVITY; SQUAMOUS CELL CARCINOMA; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT; WILD TYPE; ANIMAL; CANCER STAGING; DRUG SCREENING; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; RADIATION DOSE; RADIATION EXPOSURE; TUMOR CELL LINE;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA REPAIR; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; NEOPLASM STAGING; RADIATION TOLERANCE; RADIATION, IONIZING; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 83355168801     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027806     Document Type: Article

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