Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation

Biochemical and Biophysical Research Communications

Volumn 341, Issue 2, 2006, Pages 363-368

  Li, Zhiping ^a   Hosoi, Yoshio ^a   Cai, Keshong ^a   Tanno, Yuji ^a   Matsumoto, Yoshihisa ^a   Enomoto, Atsushi ^a   Morita, Akinori ^a   Nakagawa, Keiichi ^a   Miyagawa, Kiyoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

AG1478; EGFR; ERK; Ionizing radiation; PP2; SHP 2; Src; Transactivation

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 2;

ARTICLE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IONIZING RADIATION; PHOSPHORYLATION; PRIORITY JOURNAL; X IRRADIATION;

ANDROSTADIENES; CELL LINE, TUMOR; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENZYME ACTIVATION; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GUANOSINE TRIPHOSPHATE; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INFRARED RAYS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; PYRIMIDINES; RADIATION, IONIZING; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TEMPERATURE; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TYROSINE; TYRPHOSTINS; X-RAYS;

EID: 31444451032     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.193     Document Type: Article

References (30)

1. R.K. Schmidt-Ullrich, K. Valerie, P.B. Fogleman, and J. Walters Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells Radiat. Res. 145 1996 81 85
2. R.K. Schmidt-Ullrich, R.B. Mikkelsen, P. Dent, D.G. Todd, K. Valerie, B.D. Kavanagh, J.N. Contessa, W.K. Rorrer, and P.B. Chen Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation Oncogene 15 1997 1191 1197
3. T. Goldkorn, N. Balaban, M. Shannon, and K. Matsukuma EGF receptor phosphorylation is affected by ionizing radiation Biochim. Biophys. Acta 1358 1997 289 299
4. J.N. Contessa, J. Hampton, G. Lammering, R.B. Mikkelsen, P. Dent, K. Valerie, and R.K. Schmidt-Ullrich Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells Oncogene 21 2002 4032 4041
5. G.P. Amorino, V.M. Hamilton, K. Valerie, P. Dent, G. Lammering, and R.K. Schmidt-Ullrich Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells Mol. Biol. Cell 13 2002 2233 2244
6. K. Sato, T. Nagao, T. Iwasaki, Y. Nishihira, and Y. Fukami Src-dependent phosphorylation of the EGF receptor Tyr-845 mediates Stat-p21waf1 pathway in A431 cells Genes Cells 8 2003 995 1003
7. 2-induced transactivation of EGF receptor requires Src and mediates ERK1/2, but not Akt, activation in renal cells Am. J. Physiol. Renal Physiol. 286 2004 F858 F865
8. S. Purdom, and Q.M. Chen Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts J. Pharmacol. Exp. Ther. 312 2005 1179 1186
9. S. Zhuang, Y. Yan, J. Han, and R.G. Schnellmann p38 Kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells following oxidant injury J. Biol. Chem. 280 2005 21036 21042
10. D. Peus, A. Meves, R.A. Vasa, A. Beyerle, T. O'Brien, and M.R. Pittelkow H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activation Free Radic. Biol. Med. 27 1999 1197 1202
11. D. Kitagawa, S. Tanemura, S. Ohata, N. Shimizu, J. Seo, G. Nishitai, T. Watanabe, K. Nakagawa, H. Kishimoto, T. Wada, T. Tezuka, T. Yamamoto, H. Nishina, and T. Katada Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function J. Biol. Chem. 277 2002 366 371
12. L.K. Robertson, L.R. Mireau, and H.L. Ostergaard A role for phosphatidylinositol 3-Kinase in TCR-stimulated ERK activation leading to Paxillin phosphorylation and CTL degranulation J. Immunol. 175 2005 8138 8145
13. M. Rojas, S. Yao, and Y.Z. Lin Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor J. Biol. Chem. 271 1996 27456 27461
14. J.S. Biscardi, M.C. Maa, D.A. Tice, M.E. Cox, T.H. Leu, and S.J. Parsons c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function J. Biol. Chem. 274 1999 8335 8343
15. C.K. Qu, W.M. Yu, B. Azzarelli, and G.S. Feng Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals Proc. Natl. Acad. Sci. USA 96 1999 8528 8533
16. Y.M. Agazie, and M.J. Hayman Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling Mol. Cell. Biol. 23 2003 7875 7886
17. G.S. Feng, C.C. Hui, and T. Pawson SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases Science 259 1993 1607 1611
18. Z.Y. Peng, and C.A. Cartwright Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association Oncogene 11 1995 1955 1962
19. J.D. Bjorge, A. Jakymiw, and D.J. Fujita Selected glimpses into the activation and function of Src kinase Oncogene 19 2000 5620 5635
20. K. Chen, J.A. Vita, B.C. Berk, and J.F. Keaney Jr c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation J. Biol. Chem. 276 2001 16045 16050
21. K.K. Griendling, D. Sorescu, B. Lassegue, and M. Ushio-Fukai Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology Arterioscler. Thromb. Vasc. Biol. 20 2000 2175 2183
22. R.K. Schmidt-Ullrich, J.N. Contessa, G. Lammering, G. Amorino, and P.S. Lin ERBB receptor tyrosine kinases and cellular radiation responses Oncogene 22 2003 5855 5865
23. E. Zwick, P.O. Hackel, N. Prenzel, and A. Ullrich The EGF receptor as central transducer of heterologous signalling systems Trends Pharmacol. Sci. 20 1999 408 412
24. R. Roskoski Jr Src kinase regulation by phosphorylation and dephosphorylation Biochem. Biophys. Res. Commun. 331 2005 1 14
25. J. den Hertog, C.E. Pals, M.P. Peppelenbosch, L.G. Tertoolen, S.W. de Laat, and W. Kruijer Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation EMBO J. 12 1993 3789 3798
26. J. den Hertog, J. Sap, C.E. Pals, J. Schlessinger, and W. Kruijer Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester Cell Growth Differ. 6 1995 303 307
27. S. Tracy, P. van der Geer, and T. Hunter The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane J. Biol. Chem. 270 1995 10587 10594
28. N.K. Tonks, and B.G. Neel Combinatorial control of the specificity of protein tyrosine phosphatases Curr. Opin. Cell Biol. 13 2001 182 195
29. L.M. Sturla, G. Amorino, M.S. Alexander, R.B. Mikkelsen, K. Valerie, and R.K. Schmidt-Ullrichr Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2 J. Biol. Chem. 280 2005 14597 14604
30. A.O. Walter, Z.Y. Peng, and C.A. Cartwright The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism Oncogene 18 1999 1911 1920