The signaling and biological implications of FAK overexpression in cancer

Clinical Cancer Research

Volumn 12, Issue 11 I, 2006, Pages 3233-3237

  Siesser, Priscila M F ^a   Hanks, Steven K ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; COLLAGEN; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE;

AMINO TERMINAL SEQUENCE; CELL ADHESION; CELL INVASION; CELL MEMBRANE; CELL MOTILITY; CELL SURVIVAL; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; IMMUNOHISTOCHEMISTRY; MEDICAL LITERATURE; NOTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; SRC HOMOLOGY DOMAIN;

ANIMALS; CELL SURVIVAL; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; NEOPLASMS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 33745186178     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-0456     Document Type: Note

References (47)

1. Canel M, Secades P, Rodrigo JP, et al. Overexpression of focal adhesion kinase in head and neck squamous cell carcinoma is independent of fak-gene copy number. Clin Cancer Res 2006;12:3272-9.
2. Gabarra-Niecko V, Schaller MD, Dunty JM. FAK regulates biological processes important for pathogenesis of cancer. Cancer Metastasis Rev 2003;22:359-74.
3. Hecker TP, Gladson CL. Focal adhesion kinase in cancer. Front Biosci 2003;8:s705-14.
4. Parsons JT. Focal adhesion kinase: the first ten years. J Cell Sci 2003;116:1409-16.
5. Hanks SK, Ryzhova L, Shin NY, Brábek J. Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front Biosci 2003;8:d982-96.
6. Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 2005;6:56-68.
7. McLean GW, Carragher NO, Avizienyte E, et al. The role of focal-adhesion kinase in cancer: a new therapeutic opportunity. Nat Rev Cancer 2005;5:505-15.
8. Caron-Lormier G, Berry H. Amplification and oscillations in the FAK/Src kinase system during integrin signaling. J Theor Biol 2005;232:235-48.
9. Cooper LA, Shen TL, Guan JL. Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Mol Cell Biol 2003;23:8030-41.
10. Dunty JM, Gabarra-Niecko V, King ML, et al. FERM domain interaction promotes FAK signaling. Mol Cell Biol 2004;24:5353-68.
11. Cohen LA, Guan JL. Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation. J Biol Chem 2005;280:8197-207.
12. Ceccarelli DFJ, Song HK, Poy F et al. Crystal structure of the FERM domain of focal adhesion kinase. J Biol Chem 2006;281:252-9.
13. Ilic D, Furuta Y, Kanazawa S, et al. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 1995;377:539-44.
14. Owen JD, Ruest PJ, Fry DW, Hanks SK. Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion- dependent tyrosine phosphorylation of Pyk2. Mol Cell Biol 1999;19:4806-18.
15. Sieg DJ, Hauck CR, Schlaepfer DD. Required role of focal adhesion kinase (FAK) for integrin stimulated cell migration. J Cell Sci 1999;112:2677-91.
16. Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 2004;265:23-32.
17. Fonseca PM, Shin NY, Brábek J, et al. Regulation and localization of CAS substrate domain tyrosine phosphorylation. Cell Signal 2004;16:621-9.
18. Chodniewicz D, Klemke RL. Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim Biophys Acta 2004;1692:63-76.
19. Brown MC, Turner CE. Paxillin: adapting to change. Physiol Rev 2004;84:1315-39.
20. Tsubouchi A, Sakakura J, Yagi R, et al. Localized suppression of RhoA activity by Tyr21/118-phosphorylated paxillin in cell adhesion and migration. J Cell Biol 2002;159:673-83.
21. Webb DJ, Donais K, Whitmore LA, et al. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol 2004;6:154-61.
22. Ren XD, Kiosses WB, Sieg DJ, et al. Focal adhesion kinases suppresses Rho activity to promote focal adhesion turnover. J Cell Sci 2000;113:3673-8.
23. Yano H, Mazaki Y, Kurokawa K, et al. Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J Cell Biol 2004;166:283-95.
24. Brown MC, Cary LA, Jamieson JS, et al. Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell 2005;16:4316-28.
25. Zhai J, Lin H, Nie Z, et al. Direct interaction of focal adhesion kinase with p190RhoGEF. J Biol Chem 2003;278:24865-73.
26. Tilghman RW, Slack-Davis JK, Sergina N, et al. Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci 2005;118:2613-23.
27. Wang HB, Dembo M, Hanks SK, Wang Y. Focal adhesion kinase is involved in mechanosensing during fibroblast migration. Proc Natl Acad Sci U S A 2001;98:11295-300.
28. Linder S, Aepfelbacher M. Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol 2003;13:376-85.
29. Hsia DA, Mitra SK, Hauck CR, et al. Differential regulation of cell motility and invasion by FAK. J Cell Biol 2003;160:753-67.
30. Brábek J, Constancio SS, Shin NY, et al. CAS promotes invasiveness of Src-transformed cells. Oncogene 2004;23:7406-15.
31. Brábek J, Constancio SS, Fonseca-Siesser PM, et al. CAS substrate domain phosphorylation sites are critical for invasion and metastasis of Src-transformed cells. Mol Cancer Res 2005;3:307-15.
32. Wu XY, Gan BY, Yoo Y, Guan JL. FAK-mediated Src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Dev Cell 2005;9:185-96.
33. Frisch SM, Screaton RA. Anoikis mechanisms. Curr Opin Cell Biol 2001;13:555-62.
34. Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 1996;134:793-9.
35. Zhang Y, Lu H, Dazin P, Kapila Y. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alpha-v mediate survival signals through focal adhesion kinase. J Biol Chem 2004;279:48342-9.
36. Duxbury MS, Ito H, Zinner MJ, et al. Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells. Surgery 2004;135:55562.
37. Braren R, Hu H, Kim YH, et al. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol 2006;72:151-62.
38. Xia H, Nho RS, Kahm J, et al. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. J Biol Chem 2004;279:33024-34.
39. Sonoda Y, Matsumoto Y, Funakoshi M, et al. Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J Biol Chem 2000;275:16309-15.
40. Almeida EA, Ilic D, Han Q, et al. Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J Cell Biol 2000;149:741-54.
41. Kurenova E, Xu LH, Yang X, et al. Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol Cell Biol 2004;24:4361-71.
42. Kornberg LJ. Focal adhesion kinase expression in oral cancers. Head Neck 1998;20:634-9.
43. McLean GW, Komiyama NH, Serrels B, et al. Specific deletion of focal adhesion kinase suppresses tumour formation and blocks malignant progression. Genes Dev 2004;18:2998-3003.
44. Agochiya M, Brunton VG, Owens DW, et al. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene 1999;18:5646-53.
45. Golubovskaya V, Kaur A, Cance W. Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappaB and p53 binding sites. Biochim Biophys Acta 2004;1678:111-25.
46. Schmitz KJ, Grabellus F, Callies R, et al. High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome. Breast Cancer Res 2005;7: R194-203.
47. Itoh S, MaedaT, Shimada M, et al. Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clin Cancer Res 2004;10:2812-7.